6RNL

L-[Ru(TAP)2(dppz)]2+ bound to the G-quadruplex forming sequence d(TAGGGTT)

6RNL の概要

• エントリーDOI: 10.2210/pdb6rnl/pdb
• 分子名称: DNA (5'-D(*TP*AP*GP*GP*GP*TP*T)-3'), POTASSIUM ION, Ru(tap)2(dppz) complex, ... (5 entities in total)
• 機能のキーワード: ruthenium, intercalation, dna, asymmetric
• 由来する生物種: synthetic construct
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 11765.89

構造登録者

McQuaid, K.T.,Hall, J.P.,Cardin, C.J. (登録日: 2019-05-09, 公開日: 2019-08-28, 最終更新日: 2024-05-15)

主引用文献

McQuaid, K.,Hall, J.P.,Baumgaertner, L.,Cardin, D.J.,Cardin, C.J.
Three thymine/adenine binding modes of the ruthenium complex Lambda-[Ru(TAP)2(dppz)]2+to the G-quadruplex forming sequence d(TAGGGTT) shown by X-ray crystallography.
Chem.Commun.(Camb.), 55:9116-9119, 2019

PubMed Abstract: Λ-[Ru(TAP)2(dppz)]2+ was crystallised with the G-quadruplex-forming heptamer d(TAGGGTT). Surprisingly, even though there are four unique binding sites, the complex is not in contact with any G-quartet surface. Two complexes stabilise cavities formed from terminal T·A and T·T mismatched pairs. A third shows kinking by a TAP ligand between T·T linkages, while the fourth shows sandwiching of a dppz ligand between a T·A/T·A quadruplex and a T·T mismatch, stabilised by an additional T·A base pair stacking interaction on a TAP surface. Overall, the structure shows an unexpected affinity for thymine, and suggests models for G-quadruplex loop binding.

PubMed: 31298665
DOI: 10.1039/c9cc04316k
主引用文献が同じPDBエントリー

実験手法

X-RAY DIFFRACTION (1.88 Å)