452D

ACRIDINE BINDING TO DNA

Summary for 452D

• Entry DOI: 10.2210/pdb452d/pdb
• Descriptor: DNA (5'-D(*CP*GP*TP*AP*CP*G)-3'), 9-AMINO-(N-(2-DIMETHYLAMINO)ETHYL)ACRIDINE-4-CARBOXAMIDE, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (4 entities in total)
• Functional Keywords: intercalation, groove binding, dna
• Total number of polymer chains: 1
• Total formula weight: 2544.15

Authors

Thorpe, J.H.,Todd, A.K.,Cardin, C.J. (deposition date: 1999-02-18, release date: 2003-03-04, Last modification date: 2023-12-27)

• Primary citation: Todd, A.K.,Adams, A.,Thorpe, J.H.,Denny, W.A.,Wakelin, L.P.G.,Cardin, C.J.; Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethlyamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5Br-U)ACG)2 at 1.3-angstrom resolution; J.Med.Chem., 42:536-540, 1999; PubMed: 10052960; DOI: 10.1021/jm980479u

Experimental method

X-RAY DIFFRACTION (1.6 Å)