452D
ACRIDINE BINDING TO DNA
Summary for 452D
Entry DOI | 10.2210/pdb452d/pdb |
Descriptor | DNA (5'-D(*CP*GP*TP*AP*CP*G)-3'), 9-AMINO-(N-(2-DIMETHYLAMINO)ETHYL)ACRIDINE-4-CARBOXAMIDE, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (4 entities in total) |
Functional Keywords | intercalation, groove binding, dna |
Total number of polymer chains | 1 |
Total formula weight | 2544.15 |
Authors | Thorpe, J.H.,Todd, A.K.,Cardin, C.J. (deposition date: 1999-02-18, release date: 2003-03-04, Last modification date: 2023-12-27) |
Primary citation | Todd, A.K.,Adams, A.,Thorpe, J.H.,Denny, W.A.,Wakelin, L.P.G.,Cardin, C.J. Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethlyamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5Br-U)ACG)2 at 1.3-angstrom resolution J.Med.Chem., 42:536-540, 1999 Cited by PubMed: 10052960DOI: 10.1021/jm980479u PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
Download full validation report