8CXC
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![BU of 8cxc by Molmil](/molmil-images/mine/8cxc) | Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics | Descriptor: | 3F2 Antibody heavy chain, 3F2 Antibody light chain, Mesothelin, ... | Authors: | Bandaranayake, A.D, Rupert, P.B, Lin, I, Pilat, K, Ruff, R.O, Friend, D.J, Chan, M.K, Clarke, M, Carter, J, Meshinchi, S, Mehlin, C, Olson, J.M, Strong, R.K, Correnti, C.E. | Deposit date: | 2022-05-20 | Release date: | 2023-06-07 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (4.31 Å) | Cite: | Novel mesothelin antibodies enable crystallography of the intact mesothelin ectodomain and engineering of potent, T cell-engaging bispecific therapeutics Front. Drug Discov., 3, 2023
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8CYH
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![BU of 8cyh by Molmil](/molmil-images/mine/8cyh) | Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, A12 antibody heavy chain, A12 antibody light chain, ... | Authors: | Bandaranayake, A.D, Rupert, P.B, Lin, I, Pilat, K, Ruff, R.O, Friend, D.J, Chan, M.K, Clarke, M, Carter, J, Meshinchi, S, Mehlin, C, Olson, J.M, Strong, R.K, Correnti, C.E. | Deposit date: | 2022-05-23 | Release date: | 2023-06-07 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.38 Å) | Cite: | Novel mesothelin antibodies enable crystallography of the intact mesothelin ectodomain and engineering of potent, T cell-engaging bispecific therapeutics Front. Drug Discov., 3, 2023
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8CZ8
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![BU of 8cz8 by Molmil](/molmil-images/mine/8cz8) | Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics | Descriptor: | Mesothelin, cleaved form, SULFATE ION, ... | Authors: | Bandaranayake, A.D, Rupert, P.B, Lin, I, Pilat, K, Ruff, R.O, Friend, D.J, Chan, M.K, Clarke, M, Carter, J, Meshinchi, S, Mehlin, C, Olson, J.M, Strong, R.K, Correnti, C.E. | Deposit date: | 2022-05-24 | Release date: | 2023-06-07 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Novel mesothelin antibodies enable crystallography of the intact mesothelin ectodomain and engineering of potent, T cell-engaging bispecific therapeutics Front. Drug Discov., 3, 2023
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2BTF
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![BU of 2btf by Molmil](/molmil-images/mine/2btf) | THE STRUCTURE OF CRYSTALLINE PROFILIN-BETA-ACTIN | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, BETA-ACTIN, PROFILIN, ... | Authors: | Schutt, C.E, Myslik, J.C, Rozycki, M.D, Goonesekere, N.C.W. | Deposit date: | 1994-01-18 | Release date: | 1994-06-22 | Last modified: | 2017-11-29 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | The structure of crystalline profilin-beta-actin. Nature, 365, 1993
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3C9B
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![BU of 3c9b by Molmil](/molmil-images/mine/3c9b) | Crystal structure of SeMet Vps75 | Descriptor: | Vacuolar protein sorting-associated protein 75 | Authors: | Keck, J.L, Berndsen, C.E, Tsubota, T, Lindner, S.E, Lee, S, Holton, J.M, Kaufman, P.D, Denu, J.M. | Deposit date: | 2008-02-15 | Release date: | 2008-08-12 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.42 Å) | Cite: | Molecular functions of the histone acetyltransferase chaperone complex Rtt109-Vps75 Nat.Struct.Mol.Biol., 15, 2008
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3EFY
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![BU of 3efy by Molmil](/molmil-images/mine/3efy) | |
3ETB
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![BU of 3etb by Molmil](/molmil-images/mine/3etb) | Crystal structure of the engineered neutralizing antibody M18 complexed with anthrax protective antigen domain 4 | Descriptor: | Anthrax Protective Antigen, Antibody M18 light chain and antibody M18 heavy chain linked with a synthetic (GGGGS)4 linker | Authors: | Monzingo, A.F, Leysath, C.E, Barnett, J, Iverson, B.L, Georgiou, G, Robertus, J.D. | Deposit date: | 2008-10-07 | Release date: | 2009-04-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Crystal structure of the engineered neutralizing antibody M18 complexed to domain 4 of the anthrax protective antigen. J.Mol.Biol., 387, 2009
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3C9D
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![BU of 3c9d by Molmil](/molmil-images/mine/3c9d) | Crystal structure of Vps75 | Descriptor: | Vacuolar protein sorting-associated protein 75 | Authors: | Berndsen, C.E, Tsubota, T, Lindner, S.E, Lee, S, Holton, J.M, Kaufman, P.D, Keck, J.L, Denu, J.M. | Deposit date: | 2008-02-15 | Release date: | 2008-08-12 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Molecular functions of the histone acetyltransferase chaperone complex Rtt109-Vps75 Nat.Struct.Mol.Biol., 15, 2008
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3D6I
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![BU of 3d6i by Molmil](/molmil-images/mine/3d6i) | Structure of the Thioredoxin-like Domain of Yeast Glutaredoxin 3 | Descriptor: | Monothiol glutaredoxin-3, SULFATE ION | Authors: | Lebioda, L, Gibson, L.M, Dingra, N.N, Outten, C.E. | Deposit date: | 2008-05-19 | Release date: | 2008-09-02 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure of the thioredoxin-like domain of yeast glutaredoxin 3. Acta Crystallogr.,Sect.D, 64, 2008
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3ET9
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![BU of 3et9 by Molmil](/molmil-images/mine/3et9) | Crystal structure of the engineered neutralizing antibody 1H | Descriptor: | Antibody 1H light chain and antibody 1H heavy chain linked with a synthetic (GGGGS)4 linker | Authors: | Leysath, C.E, Monzingo, A.F, Barnett, J, Iverson, B.L, Georgiou, G, Robertus, J.D. | Deposit date: | 2008-10-07 | Release date: | 2009-04-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of the engineered neutralizing antibody m18 complexed to domain 4 of the anthrax protective antigen. J.Mol.Biol., 387, 2009
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3ESV
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![BU of 3esv by Molmil](/molmil-images/mine/3esv) | Crystal structure of the engineered neutralizing antibody M18 | Descriptor: | Antibody M18 light chain and antibody M18 heavy chain linked with a synthetic (GGGGS)4 linker | Authors: | Monzingo, A.F, Leysath, C.E, Barnett, J, Iverson, B.L, Georgiou, G, Robertus, J.D. | Deposit date: | 2008-10-06 | Release date: | 2009-04-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the engineered neutralizing antibody m18 complexed to domain 4 of the anthrax protective antigen. J.Mol.Biol., 387, 2009
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8GLR
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![BU of 8glr by Molmil](/molmil-images/mine/8glr) | FrlB - Deglycase for 6-phosphofructose lysine | Descriptor: | GLYCEROL, SIS domain-containing protein | Authors: | Bell, C.E, Gopalan, V, Kovvali, S. | Deposit date: | 2023-03-22 | Release date: | 2023-07-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Insights into the catalytic mechanism of a bacterial deglycase essential for utilization of fructose-lysine. Protein Sci., 32, 2023
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8QDC
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![BU of 8qdc by Molmil](/molmil-images/mine/8qdc) | Crystal structure of SARS-CoV-2 main protease (MPro) in complex with the covalent inhibitor GUE-3642 (compound 1 in publication) | Descriptor: | (phenylmethyl) ~{N}-[(2~{S})-1-[[(2~{S})-1-[[(2~{S})-1-[[iminomethyl-(phenylmethyl)amino]-methyl-amino]-1-oxidanylidene-3-phenyl-propan-2-yl]amino]-3,3-dimethyl-1-oxidanylidene-butan-2-yl]amino]-1-oxidanylidene-butan-2-yl]carbamate, 3C-like proteinase nsp5, CHLORIDE ION, ... | Authors: | Strater, N, Claff, T, Sylvester, K, Mueller, C.E, Guetschow, M. | Deposit date: | 2023-08-28 | Release date: | 2024-07-03 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Development of an active-site titrant for SARS-CoV-2 main protease as an indispensable tool for evaluating enzyme kinetics. Acta Pharm Sin B, 14, 2024
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8S99
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![BU of 8s99 by Molmil](/molmil-images/mine/8s99) | Crystal structure of the TYK2 pseudokinase domain in complex with compound 11 | Descriptor: | (8S)-N-[(1R,2S)-2-fluorocyclopropyl]-5-{[(1M,2'M)-3'-fluoro-2-oxo-2H-[1,2'-bipyridin]-3-yl]amino}-7-(methylamino)pyrazolo[1,5-a]pyrimidine-3-carboxamide, 1,2-ETHANEDIOL, ACETATE ION, ... | Authors: | Toms, A.V, Leit, S, Greenwood, J.R, Carriero, S, Mondal, S, Abel, R, Ashwell, M, Blanchette, H, Boyles, N, Cartwright, M, Collis, A, Feng, S, Ghanakota, P, Harriman, G.C, Hosagrahara, V, Kaila, N, Kapeller, R, Rafi, S, Romero, D.L, Tarantino, P, Timaniya, J, Wester, R.T, Westlin, W, Srivastava, B, Miao, W, Tummino, P, McElwee, J.J, Edmondson, S.D, Massee, C.E. | Deposit date: | 2023-03-27 | Release date: | 2023-07-26 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279. J.Med.Chem., 66, 2023
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8S9A
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![BU of 8s9a by Molmil](/molmil-images/mine/8s9a) | Crystal structure of the TYK2 pseudokinase domain in complex with TAK-279 | Descriptor: | (8S)-N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-{[(1P,2'P)-2-oxo-2H-[1,2'-bipyridin]-3-yl]amino}pyrazolo[1,5-a]pyrimidine-3-carboxamide, 1,2-ETHANEDIOL, ACETATE ION, ... | Authors: | Toms, A.V, Leit, S, Greenwood, J.R, Carriero, S, Mondal, S, Abel, R, Ashwell, M, Blanchette, H, Boyles, N, Cartwright, M, Collis, A, Feng, S, Ghanakota, P, Harriman, G.C, Hosagrahara, V, Kaila, N, Kapeller, R, Rafi, S, Romero, D.L, Tarantino, P, Timaniya, J, Wester, R.T, Westlin, W, Srivastava, B, Miao, W, Tummino, P, McElwee, J.J, Edmondson, S.D, Massee, C.E. | Deposit date: | 2023-03-27 | Release date: | 2023-07-26 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279. J.Med.Chem., 66, 2023
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8S98
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![BU of 8s98 by Molmil](/molmil-images/mine/8s98) | Crystal structure of the TYK2 pseudokinase domain in complex with compound 8 | Descriptor: | (8S)-N-cyclopropyl-5-[(2-methoxypyridin-3-yl)amino]-7-(methylamino)pyrazolo[1,5-a]pyrimidine-3-carboxamide, Non-receptor tyrosine-protein kinase TYK2 | Authors: | Toms, A.V, Leit, S, Greenwood, J.R, Carriero, S, Mondal, S, Abel, R, Ashwell, M, Blanchette, H, Boyles, N, Cartwright, M, Collis, A, Feng, S, Ghanakota, P, Harriman, G.C, Hosagrahara, V, Kaila, N, Kapeller, R, Rafi, S, Romero, D.L, Tarantino, P, Timaniya, J, Wester, R.T, Westlin, W, Srivastava, B, Miao, W, Tummino, P, McElwee, J.J, Edmondson, S.D, Massee, C.E. | Deposit date: | 2023-03-27 | Release date: | 2023-07-26 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279. J.Med.Chem., 66, 2023
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7UBB
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![BU of 7ubb by Molmil](/molmil-images/mine/7ubb) | |
4CSB
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![BU of 4csb by Molmil](/molmil-images/mine/4csb) | Structure of the Virulence-Associated Protein VapD from the intracellular pathogen Rhodococcus equi. | Descriptor: | VIRULENCE ASSOCIATED PROTEIN VAPD, octyl beta-D-glucopyranoside | Authors: | Whittingham, J.L, Blagova, E.V, Finn, C.E, Luo, H, Miranda-CasoLuengo, R, Turkenburg, J.P, Leech, A.P, Walton, P.H, Meijers, W.G, Wilkinson, A.J. | Deposit date: | 2014-03-06 | Release date: | 2014-04-16 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure of the Virulence-Associated Protein Vapd from the Intracellular Pathogen Rhodococcus Equi. Acta Crystallogr.,Sect.D, 70, 2014
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2LYM
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![BU of 2lym by Molmil](/molmil-images/mine/2lym) | |
7UVY
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![BU of 7uvy by Molmil](/molmil-images/mine/7uvy) | A. baumannii ribosome-Streptothricin-D complex: 70S with P-site tRNA | Descriptor: | 16s Ribosomal RNA, 23s ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Morgan, C.E, Yu, E.W. | Deposit date: | 2022-05-02 | Release date: | 2023-04-19 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.39 Å) | Cite: | Streptothricin F is a bactericidal antibiotic effective against highly drug-resistant gram-negative bacteria that interacts with the 30S subunit of the 70S ribosome. Plos Biol., 21, 2023
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7UVV
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![BU of 7uvv by Molmil](/molmil-images/mine/7uvv) | A. baumannii ribosome-Streptothricin-F complex: 70S with P-site tRNA | Descriptor: | 16s Ribosomal RNA, 23s ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Morgan, C.E, Yu, E.W. | Deposit date: | 2022-05-02 | Release date: | 2023-04-19 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Streptothricin F is a bactericidal antibiotic effective against highly drug-resistant gram-negative bacteria that interacts with the 30S subunit of the 70S ribosome. Plos Biol., 21, 2023
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7UVW
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![BU of 7uvw by Molmil](/molmil-images/mine/7uvw) | A. baumannii ribosome: 70S with E-site tRNA | Descriptor: | 16s Ribosomal RNA, 23s ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Morgan, C.E, Yu, E.W. | Deposit date: | 2022-05-02 | Release date: | 2023-04-19 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.37 Å) | Cite: | Streptothricin F is a bactericidal antibiotic effective against highly drug-resistant gram-negative bacteria that interacts with the 30S subunit of the 70S ribosome. Plos Biol., 21, 2023
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7UVZ
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![BU of 7uvz by Molmil](/molmil-images/mine/7uvz) | A. baumannii ribosome-Streptothricin-D complex: 70S with E-site tRNA | Descriptor: | 16s Ribosomal RNA, 23s ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Morgan, C.E, Yu, E.W. | Deposit date: | 2022-05-02 | Release date: | 2023-04-19 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.21 Å) | Cite: | Streptothricin F is a bactericidal antibiotic effective against highly drug-resistant gram-negative bacteria that interacts with the 30S subunit of the 70S ribosome. Plos Biol., 21, 2023
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7UVX
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![BU of 7uvx by Molmil](/molmil-images/mine/7uvx) | A. baumannii 70S ribosome-Streptothricin-F complex | Descriptor: | 16s Ribosomal RNA, 23s ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Morgan, C.E, Yu, E.W. | Deposit date: | 2022-05-02 | Release date: | 2023-04-19 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.35 Å) | Cite: | Streptothricin F is a bactericidal antibiotic effective against highly drug-resistant gram-negative bacteria that interacts with the 30S subunit of the 70S ribosome. Plos Biol., 21, 2023
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7UB2
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![BU of 7ub2 by Molmil](/molmil-images/mine/7ub2) | |