2BTF

THE STRUCTURE OF CRYSTALLINE PROFILIN-BETA-ACTIN

Summary for 2BTF

• Entry DOI: 10.2210/pdb2btf/pdb
• Descriptor: BETA-ACTIN, PROFILIN, STRONTIUM ION, ... (4 entities in total)
• Functional Keywords: acetylation and actin-binding
• Biological source: Bos taurus (cattle); More
• Cellular location: Cytoplasm, cytoskeleton: P60712 P02584
• Total number of polymer chains: 2
• Total formula weight: 57253.51

Authors

Schutt, C.E.,Myslik, J.C.,Rozycki, M.D.,Goonesekere, N.C.W. (deposition date: 1994-01-18, release date: 1994-06-22, Last modification date: 2025-03-26)

Primary citation

Schutt, C.E.,Myslik, J.C.,Rozycki, M.D.,Goonesekere, N.C.,Lindberg, U.
The structure of crystalline profilin-beta-actin.
Nature, 365:810-816, 1993

PubMed Abstract: The three-dimensional structure of bovine profilin-beta-actin has been solved to 2.55 A resolution by X-ray crystallography. There are several significant local changes in the structure of beta-actin compared with alpha-actin as well as an overall 5 degrees rotation between its two major domains. Actin molecules in the crystal are organized into ribbons through intermolecular contacts like those found in oligomeric protein assemblies. Profilin forms two extensive contacts with the actin ribbon, one of which appears to correspond to the solution contact in vitro.

PubMed: 8413665
DOI: 10.1038/365810a0

Experimental method

X-RAY DIFFRACTION (2.55 Å)