3U1Y
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![BU of 3u1y by Molmil](/molmil-images/mine/3u1y) | Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections | Descriptor: | (2R)-N-hydroxy-2-methyl-2-(methylsulfonyl)-4-{4'-[3-(morpholin-4-yl)propoxy]biphenyl-4-yl}butanamide, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION | Authors: | Brown, M, Abramite, J, Liu, S. | Deposit date: | 2011-09-30 | Release date: | 2012-01-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Potent inhibitors of LpxC for the treatment of Gram-negative infections. J.Med.Chem., 55, 2012
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6YBA
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![BU of 6yba by Molmil](/molmil-images/mine/6yba) | HAdV-F41 Capsid | Descriptor: | Hexon protein, Hexon-interlacing protein, Penton protein, ... | Authors: | Perez Illana, M, Martinez, M, Mangroo, C, Brown, M, Marabini, R, San Martin, C. | Deposit date: | 2020-03-16 | Release date: | 2021-03-10 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Cryo-EM structure of enteric adenovirus HAdV-F41 highlights structural variations among human adenoviruses. Sci Adv, 7, 2021
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4H56
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![BU of 4h56 by Molmil](/molmil-images/mine/4h56) | Crystal structure of the Clostridium perfringens NetB toxin in the membrane inserted form | Descriptor: | Necrotic enteritis toxin B | Authors: | Savva, C.G, Fernandes da Costa, S.P, Bokori-Brown, M, Naylor, C, Cole, A.R, Moss, D.S, Titball, R.W, Basak, A.K. | Deposit date: | 2012-09-18 | Release date: | 2012-12-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.9 Å) | Cite: | Molecular Architecture and Functional Analysis of NetB, a Pore-forming Toxin from Clostridium perfringens. J.Biol.Chem., 288, 2013
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3ZJX
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![BU of 3zjx by Molmil](/molmil-images/mine/3zjx) | Clostridium perfringens epsilon toxin mutant H149A bound to octyl glucoside | Descriptor: | EPSILON-TOXIN, PHOSPHATE ION, octyl beta-D-glucopyranoside | Authors: | Bokori-Brown, M, Kokkinidou, M.C, Savva, C.G, Fernandes da Costa, S.P, Naylor, C.E, Cole, A.R, Basak, A.K, Titball, R.W. | Deposit date: | 2013-01-20 | Release date: | 2013-03-27 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Clostridium Perfringens Epsilon Toxin H149A Mutant as a Platform for Receptor Binding Studies. Protein Sci., 22, 2013
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6RB9
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![BU of 6rb9 by Molmil](/molmil-images/mine/6rb9) | The pore structure of Clostridium perfringens epsilon toxin | Descriptor: | Epsilon-toxin type B | Authors: | Savva, C.G, Clark, A.R, Naylor, C.E, Popoff, M.R, Moss, D.S, Basak, A.K, Titball, R.W, Bokori-Brown, M. | Deposit date: | 2019-04-09 | Release date: | 2019-06-19 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | The pore structure of Clostridium perfringens epsilon toxin. Nat Commun, 10, 2019
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5GAQ
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![BU of 5gaq by Molmil](/molmil-images/mine/5gaq) | Cryo-EM structure of the Lysenin Pore | Descriptor: | Lysenin | Authors: | Savva, C.G, Bokori-Brown, M, Martin, T.G, Titball, R.W, Naylor, C.E, Basak, A.K. | Deposit date: | 2016-01-05 | Release date: | 2016-04-06 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Cryo-EM structure of lysenin pore elucidates membrane insertion by an aerolysin family protein Nat Commun, 7, 2016
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1VZO
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![BU of 1vzo by Molmil](/molmil-images/mine/1vzo) | The structure of the N-terminal kinase domain of MSK1 reveals a novel autoinhibitory conformation for a dual kinase protein | Descriptor: | BETA-MERCAPTOETHANOL, RIBOSOMAL PROTEIN S6 KINASE ALPHA 5, SULFATE ION | Authors: | Smith, K.J, Carter, P.S, Bridges, A, Horrocks, P, Lewis, C, Pettman, G, Clarke, A, Brown, M, Hughes, J, Wilkinson, M, Bax, B, Reith, A. | Deposit date: | 2004-05-21 | Release date: | 2004-06-11 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The Structure of Msk1 Reveals a Novel Autoinhibitory Conformation for a Dual Kinase Protein Structure, 12, 2004
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1DL7
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![BU of 1dl7 by Molmil](/molmil-images/mine/1dl7) | |
3JCA
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![BU of 3jca by Molmil](/molmil-images/mine/3jca) | Core model of the Mouse Mammary Tumor Virus intasome | Descriptor: | 5'-D(*AP*AP*TP*GP*CP*CP*GP*CP*AP*GP*TP*CP*GP*GP*CP*CP*GP*AP*CP*CP*TP*G)-3', 5'-D(*CP*AP*GP*GP*TP*CP*GP*GP*CP*CP*GP*AP*CP*TP*GP*CP*GP*GP*CP*A)-3', Integrase, ... | Authors: | Lyumkis, D.L, Ballandras-Colas, A, Brown, M, Cook, N.J, Dewdney, T.G, Demeler, B, Cherepanov, P, Engelman, A.N. | Deposit date: | 2015-11-24 | Release date: | 2016-02-17 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function. Nature, 530, 2016
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4J5P
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![BU of 4j5p by Molmil](/molmil-images/mine/4j5p) | Crystal Structure of a Covalently Bound alpha-Ketoheterocycle Inhibitor (Phenhexyl/Oxadiazole/Pyridine) to a Humanized Variant of Fatty Acid Amide Hydrolase | Descriptor: | (1S)-1-{5-[5-(bromomethyl)pyridin-2-yl]-1,3-oxazol-2-yl}-7-phenylheptan-1-ol, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Otrubova, K, Brown, M, McCormick, M.S, Han, G.W, O'Neal, S.T, Cravatt, B.F, Stevens, R.C, Lichtman, A.H, Boger, D.L. | Deposit date: | 2013-02-08 | Release date: | 2013-05-01 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Rational design of Fatty Acid amide hydrolase inhibitors that act by covalently bonding to two active site residues. J.Am.Chem.Soc., 135, 2013
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3RU0
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![BU of 3ru0 by Molmil](/molmil-images/mine/3ru0) | Cocrystal structure of human SMYD3 with inhibitor Sinefungin bound | Descriptor: | SET and MYND domain-containing protein 3, SINEFUNGIN, ZINC ION | Authors: | Foreman, K.W, Brown, M, Park, F, Emtage, S, Harriss, J, Das, C, Zhu, L, Crew, A, Arnold, L, Shaaban, S, Tucker, P. | Deposit date: | 2011-05-04 | Release date: | 2011-05-18 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.849 Å) | Cite: | Structural and Functional Profiling of the Human Histone Methyltransferase SMYD3. Plos One, 6, 2011
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1OZ1
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![BU of 1oz1 by Molmil](/molmil-images/mine/1oz1) | P38 MITOGEN-ACTIVATED KINASE IN COMPLEX WITH 4-AZAINDOLE INHIBITOR | Descriptor: | 3-(4-FLUOROPHENYL)-2-PYRIDIN-4-YL-1H-PYRROLO[3,2-B]PYRIDIN-1-OL, Mitogen-activated protein kinase 14 | Authors: | Lovejoy, B, Villasenor, A, Browner, M, Dunten, P. | Deposit date: | 2003-04-07 | Release date: | 2003-09-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Design and synthesis of 4-azaindoles as inhibitors of p38 MAP kinase. J.Med.Chem., 46, 2003
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