6OO7
 
 | | Cryo-EM structure of the C2-symmetric TRPV2/RTx complex in nanodiscs | | Descriptor: | TRPV2, resiniferatoxin | | Authors: | Zubcevic, L, Hsu, A.L, Borgnia, M.J, Lee, S.-Y. | | Deposit date: | 2019-04-22 | | Release date: | 2019-05-29 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes.
Elife, 8, 2019
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6OO5
 | | Cryo-EM structure of the C2-symmetric TRPV2/RTx complex in amphipol resolved to 4.2 A | | Descriptor: | TRPV2, resiniferatoxin | | Authors: | Zubcevic, L, Hsu, A.L, Borgnia, M.J, Lee, S.-Y. | | Deposit date: | 2019-04-22 | | Release date: | 2019-05-29 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes.
Elife, 8, 2019
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6OO3
 | | Cryo-EM structure of the C4-symmetric TRPV2/RTx complex in amphipol resolved to 2.9 A | | Descriptor: | TRPV2, resiniferatoxin | | Authors: | Zubcevic, L, Hsu, A.L, Borgnia, M.J, Lee, S.-Y. | | Deposit date: | 2019-04-22 | | Release date: | 2019-05-29 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes.
Elife, 8, 2019
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6OT5
 | | Structure of the TRPV3 K169A sensitized mutant in the presence of 2-APB at 3.6 A resolution | | Descriptor: | 2-aminoethyl diphenylborinate, Transient receptor potential cation channel subfamily V member 3,Transient receptor potential cation channel subfamily V member 3 | | Authors: | Zubcevic, L, Borschel, W.F, Hsu, A.L, Borgnia, M.J, Lee, S.-Y. | | Deposit date: | 2019-05-02 | | Release date: | 2019-05-22 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Regulatory switch at the cytoplasmic interface controls TRPV channel gating.
Elife, 8, 2019
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6OO4
 | | Cryo-EM structure of the C2-symmetric TRPV2/RTx complex in amphipol resolved to 3.3 A | | Descriptor: | TRPV2, resiniferatoxin | | Authors: | Zubcevic, L, Hsu, A.L, Borgnia, M.J, Lee, S.-Y. | | Deposit date: | 2019-04-22 | | Release date: | 2019-05-29 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes.
Elife, 8, 2019
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6OT2
 | | Structure of the TRPV3 K169A sensitized mutant in apo form at 4.1 A resolution | | Descriptor: | Transient receptor potential cation channel subfamily V member 3 | | Authors: | Zubcevic, L, Borschel, W.F, Hsu, A.L, Borgnia, M.J, Lee, S.-Y. | | Deposit date: | 2019-05-02 | | Release date: | 2019-05-22 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Regulatory switch at the cytoplasmic interface controls TRPV channel gating.
Elife, 8, 2019
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7T8B
 | | Octameric Human Twinkle Helicase Clinical Variant W315L | | Descriptor: | Twinkle mtDNA helicase | | Authors: | Riccio, A.A, Bouvette, J, Krahn, J, Borgnia, M.J, Copeland, W.C. | | Deposit date: | 2021-12-16 | | Release date: | 2022-07-27 | | Last modified: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structural insight and characterization of human Twinkle helicase in mitochondrial disease.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7T8C
 | | Heptameric Human Twinkle Helicase Clinical Variant W315L | | Descriptor: | Twinkle mtDNA helicase | | Authors: | Riccio, A.A, Bouvette, J, Krahn, J, Borgnia, M.J, Copeland, W.C. | | Deposit date: | 2021-12-16 | | Release date: | 2022-07-27 | | Last modified: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | Structural insight and characterization of human Twinkle helicase in mitochondrial disease.
Proc.Natl.Acad.Sci.USA, 119, 2022
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6UKP
 | | Apo mBcs1 | | Descriptor: | Mitochondrial chaperone BCS1 | | Authors: | Tang, W.K, Borgnia, M.J, Hsu, A.L, Xia, D. | | Deposit date: | 2019-10-05 | | Release date: | 2020-02-12 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.81 Å) | | Cite: | Structures of AAA protein translocase Bcs1 suggest translocation mechanism of a folded protein.
Nat.Struct.Mol.Biol., 27, 2020
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8E4P
 | | Mouse TRPM8 structure determined in the ligand- and PI(4,5)P2-free condition, Class I , C0 state | | Descriptor: | CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 8 | | Authors: | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | | Deposit date: | 2022-08-18 | | Release date: | 2022-10-26 | | Method: | ELECTRON MICROSCOPY (3.59 Å) | | Cite: | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Science, 378, 2022
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8E4M
 | | The intermediate C2-state mouse TRPM8 structure in complex with the cooling agonist C3 and PI(4,5)P2 | | Descriptor: | CALCIUM ION, Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, ... | | Authors: | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | | Deposit date: | 2022-08-18 | | Release date: | 2022-10-26 | | Method: | ELECTRON MICROSCOPY (3.44 Å) | | Cite: | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Science, 378, 2022
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8E4L
 | | The open state mouse TRPM8 structure in complex with the cooling agonist C3, AITC, and PI(4,5)P2 | | Descriptor: | 3-isothiocyanatoprop-1-ene, CALCIUM ION, Transient receptor potential cation channel subfamily M member 8, ... | | Authors: | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | | Deposit date: | 2022-08-18 | | Release date: | 2022-10-26 | | Method: | ELECTRON MICROSCOPY (3.32 Å) | | Cite: | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Science, 378, 2022
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8E4O
 | | The closed C1-state mouse TRPM8 structure in complex with putative PI(4,5)P2 | | Descriptor: | Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | | Authors: | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | | Deposit date: | 2022-08-18 | | Release date: | 2022-10-26 | | Method: | ELECTRON MICROSCOPY (3.43 Å) | | Cite: | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Science, 378, 2022
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8E4Q
 | | The closed C0-state flycatcher TRPM8 structure in complex with PI(4,5)P2 | | Descriptor: | Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | | Authors: | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | | Deposit date: | 2022-08-18 | | Release date: | 2022-10-26 | | Method: | ELECTRON MICROSCOPY (3.51 Å) | | Cite: | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Science, 378, 2022
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8E4N
 | | The closed C1-state mouse TRPM8 structure in complex with PI(4,5)P2 | | Descriptor: | Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | | Authors: | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | | Deposit date: | 2022-08-18 | | Release date: | 2022-10-26 | | Method: | ELECTRON MICROSCOPY (3.07 Å) | | Cite: | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Science, 378, 2022
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8DTF
 | | Cryo-EM structure of the full length Arabidopsis SPY with complete TPRs | | Descriptor: | Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY | | Authors: | Kumar, S, Zhou, Y, Dillard, L, Borgnia, M.J, Bartesaghi, A, Zhou, P. | | Deposit date: | 2022-07-25 | | Release date: | 2023-03-08 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Cryo-EM structure of the full length Arabidopsis SPY with complete TPRs
Nat Commun, 2023
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8DTH
 | | Cryo-EM structure of Arabidopsis SPY alternative conformation 2 | | Descriptor: | Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY | | Authors: | Kumar, S, Zhou, Y, Dillard, L, Borgnia, M.J, Bartesaghi, A, Zhou, P. | | Deposit date: | 2022-07-25 | | Release date: | 2023-03-08 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Cryo-EM structure of the full length Arabidopsis SPY with complete TPRs
Nat Commun, 2023
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8DTI
 | | Cryo-EM structure of Arabidopsis SPY in complex with GDP-fucose | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE-BETA-L-FUCOPYRANOSE, Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY | | Authors: | Kumar, S, Zhou, Y, Dillard, L, Borgnia, M.J, Bartesaghi, A, Zhou, P. | | Deposit date: | 2022-07-25 | | Release date: | 2023-03-08 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Cryo-EM structure of the full length Arabidopsis SPY with complete TPRs
Nat Commun, 2023
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8DTG
 | | Cryo-EM structure of Arabidopsis SPY alternative conformation 1 | | Descriptor: | Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY | | Authors: | Kumar, S, Zhou, Y, Dillard, L, Borgnia, M.J, Bartesaghi, A, Zhou, P. | | Deposit date: | 2022-07-25 | | Release date: | 2023-03-08 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Cryo-EM structure of the full length Arabidopsis SPY with complete TPRs
Nat Commun, 2023
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