5V7O
 
 | | Crystal Structure of NosK from Streptomyces actuosus | | Descriptor: | NosK, SULFATE ION | | Authors: | Booker, S.J, Boal, A.K, Grove, T.L, Badding, E.D. | | Deposit date: | 2017-03-20 | | Release date: | 2017-04-12 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Rerouting the Pathway for the Biosynthesis of the Side Ring System of Nosiheptide: The Roles of NosI, NosJ, and NosK.
J. Am. Chem. Soc., 139, 2017
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5VNP
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5UY1
 | | X-ray crystal structure of apo Halotag | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Haloalkane dehalogenase | | Authors: | Dunham, N.P, Boal, A.K. | | Deposit date: | 2017-02-23 | | Release date: | 2017-03-08 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | The Cation-pi Interaction Enables a Halo-Tag Fluorogenic Probe for Fast No-Wash Live Cell Imaging and Gel-Free Protein Quantification.
Biochemistry, 56, 2017
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5UXZ
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8CVD
 | | Structure of Hyoscyamine 6-beta Hydroxylase in complex with iron, succinate, and scopolamine | | Descriptor: | (1R,2R,4S,5S,7s)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0~2,4~]nonan-7-yl (2S)-3-hydroxy-2-phenylpropanoate, 1,2-ETHANEDIOL, FE (II) ION, ... | | Authors: | Wenger, E.W, Boal, A.K, Bollinger, J.M, Krebs, C. | | Deposit date: | 2022-05-18 | | Release date: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.717 Å) | | Cite: | Structure of the H6H cyclization product complex
To Be Published
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8CVA
 | | Structure of Hyoscyamine 6-beta Hydroxylase in complex with iron, succinate, and 6-OH-hyoscyamine | | Descriptor: | (1R,3S,5R,6S)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl (2S)-3-hydroxy-2-phenylpropanoate, 1,2-ETHANEDIOL, FE (II) ION, ... | | Authors: | Wenger, E.W, Boal, A.K, Bollinger, J.M, Krebs, C. | | Deposit date: | 2022-05-18 | | Release date: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.581 Å) | | Cite: | Structure of the H6H hydroxylation product complex
To Be Published
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8CVC
 | | Structure of Hyoscyamine 6-beta Hydroxylase in complex with vanadyl, succinate, and 6-OH-hyoscyamine | | Descriptor: | (1R,3S,5R,6S)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl (2S)-3-hydroxy-2-phenylpropanoate, 1,2-ETHANEDIOL, FORMIC ACID, ... | | Authors: | Wenger, E.W, Boal, A.K, Bollinger, J.M, Krebs, C. | | Deposit date: | 2022-05-18 | | Release date: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.791 Å) | | Cite: | Structure mimicking the H6H cyclization ferryl complex
To Be Published
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8CV8
 | | Structure of Hyoscyamine 6-beta Hydroxylase in complex with iron, 2-oxoglutarate, and hyoscyamine | | Descriptor: | 1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, FE (II) ION, ... | | Authors: | Wenger, E.W, Boal, A.K, Bollinger, J.M, Krebs, C. | | Deposit date: | 2022-05-18 | | Release date: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.532 Å) | | Cite: | Structure of the H6H hydroxylation reactant complex
To Be Published
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8CVB
 | | Structure of Hyoscyamine 6-beta Hydroxylase in complex with iron, 2-oxoglutarate, and 6-OH-hyoscyamine | | Descriptor: | (1R,3S,5R,6S)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl (2S)-3-hydroxy-2-phenylpropanoate, 1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, ... | | Authors: | Wenger, E.W, Boal, A.K, Bollinger, J.M, Krebs, C. | | Deposit date: | 2022-05-18 | | Release date: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.532 Å) | | Cite: | Structure of the H6H cyclization reactant complex
To Be Published
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8CV9
 | | Structure of Hyoscyamine 6-beta Hydroxylase in complex with vanadyl, succinate, and hyoscyamine | | Descriptor: | 1,2-ETHANEDIOL, FORMIC ACID, Hyoscyamine 6-beta-hydroxylase, ... | | Authors: | Wenger, E.W, Boal, A.K, Bollinger, J.M, Krebs, C. | | Deposit date: | 2022-05-18 | | Release date: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.79 Å) | | Cite: | Structure of the H6H hydroxylation reactant complex
To Be Published
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8CVG
 | | Structure of L289F Hyoscyamine 6-beta Hydroxylase in complex with iron, 2-oxoglutarate, and 6-OH-hyoscyamine | | Descriptor: | (1R,3S,5R,6S)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl (2S)-3-hydroxy-2-phenylpropanoate, 1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, ... | | Authors: | Wenger, E.W, Boal, A.K, Bollinger, J.M, Krebs, C. | | Deposit date: | 2022-05-18 | | Release date: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.56 Å) | | Cite: | Structure of the L289F H6H cyclization reactant complex
To Be Published
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8CVF
 | | Structure of L289F Hyoscyamine 6-beta Hydroxylase in complex with vanadyl, succinate, and hyoscyamine | | Descriptor: | 1,2-ETHANEDIOL, FORMIC ACID, Hyoscyamine 6-beta-hydroxylase, ... | | Authors: | Wenger, E.W, Boal, A.K, Bollinger, J.M, Krebs, C. | | Deposit date: | 2022-05-18 | | Release date: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.532 Å) | | Cite: | Structure of the L289F H6H ferryl-mimicking complex
To Be Published
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8CVE
 | | Structure of L289F Hyoscyamine 6-beta Hydroxylase in complex with iron, 2-oxoglutarate, and hyoscyamine | | Descriptor: | 1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, FE (II) ION, ... | | Authors: | Wenger, E.W, Boal, A.K, Bollinger, J.M, Krebs, C. | | Deposit date: | 2022-05-18 | | Release date: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.53 Å) | | Cite: | Structure of the L289F H6H hydroxylation reactant complex
To Be Published
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8CVH
 | | Structure of L289F Hyoscyamine 6-beta Hydroxylase in complex with vanadyl, succinate, and 6-OH-hyoscyamine | | Descriptor: | (1R,3S,5R,6S)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl (2S)-3-hydroxy-2-phenylpropanoate, 1,2-ETHANEDIOL, FORMIC ACID, ... | | Authors: | Wenger, E.W, Boal, A.K, Bollinger, J.M, Krebs, C. | | Deposit date: | 2022-05-18 | | Release date: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | Structure of the L289F H6H cyclization ferryl-mimicking complex
To Be Published
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7KDY
 | | Crystal structure of Streptomyces tokunonesis TokK with hydroxycobalamin, 5'-deoxyadenosine, methionine, and (2R)-pantetheinylated carbapenam | | Descriptor: | (2R,3R,5R)-3-{[2-({N-[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]-beta-alanyl}amino)ethyl]sulfanyl}-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 5'-DEOXYADENOSINE, COBALAMIN, ... | | Authors: | Knox, H.L, Booker, S.J, Boal, A.K. | | Deposit date: | 2020-10-09 | | Release date: | 2022-01-12 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.939 Å) | | Cite: | Structure of a B 12 -dependent radical SAM enzyme in carbapenem biosynthesis.
Nature, 602, 2022
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7KDX
 | | Crystal structure of Streptomyces tokunonesis TokK with hydroxycobalamin, 5'-deoxyadenosine, and methionine | | Descriptor: | 1,2-ETHANEDIOL, 5'-DEOXYADENOSINE, CHLORIDE ION, ... | | Authors: | Knox, H.L, Booker, S.J, Boal, A.K. | | Deposit date: | 2020-10-09 | | Release date: | 2022-01-12 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (1.791 Å) | | Cite: | Structure of a B 12 -dependent radical SAM enzyme in carbapenem biosynthesis.
Nature, 602, 2022
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7KPI
 | | Crystal structure of the SPOP MATH domain | | Descriptor: | Speckle-type POZ protein | | Authors: | Usher, E.T, Boal, A.K. | | Deposit date: | 2020-11-11 | | Release date: | 2021-04-28 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Intrinsically disordered substrates dictate SPOP subnuclear localization and ubiquitination activity.
J.Biol.Chem., 296, 2021
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7KPK
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5HR6
 | | X-ray crystal structure of C118A RlmN with cross-linked tRNA purified from Escherichia coli | | Descriptor: | 5'-DEOXYADENOSINE, IRON/SULFUR CLUSTER, MAGNESIUM ION, ... | | Authors: | Schwalm, E.L, Grove, T.L, Booker, S.J, Boal, A.K. | | Deposit date: | 2016-01-22 | | Release date: | 2016-04-13 | | Last modified: | 2016-04-27 | | Method: | X-RAY DIFFRACTION (2.88 Å) | | Cite: | Crystallographic capture of a radical S-adenosylmethionine enzyme in the act of modifying tRNA.
Science, 352, 2016
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5HR7
 | | X-ray crystal structure of C118A RlmN from Escherichia coli with cross-linked in vitro transcribed tRNA | | Descriptor: | 5'-DEOXYADENOSINE, Dual-specificity RNA methyltransferase RlmN, IRON/SULFUR CLUSTER, ... | | Authors: | Schwalm, E.L, Grove, T.L, Booker, S.J, Boal, A.K. | | Deposit date: | 2016-01-22 | | Release date: | 2016-04-13 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystallographic capture of a radical S-adenosylmethionine enzyme in the act of modifying tRNA.
Science, 352, 2016
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5IQV
 | | WelO5 bound to Fe, Cl, 2-oxoglutarate, 12-epifischerindole U, and nitric oxide | | Descriptor: | (6aS,9R,10R,10aS)-9-ethyl-10-isocyano-6,6,9-trimethyl-5,6,6a,7,8,9,10,10a-octahydroindeno[2,1-b]indole, 2-OXOGLUTARIC ACID, CHLORIDE ION, ... | | Authors: | Mitchell, A.J, Boal, A.K. | | Deposit date: | 2016-03-11 | | Release date: | 2016-06-29 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural basis for halogenation by iron- and 2-oxo-glutarate-dependent enzyme WelO5.
Nat.Chem.Biol., 12, 2016
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5IQT
 | | WelO5 bound to Fe(II), Cl, 2-oxoglutarate, and 12-epifischerindole U | | Descriptor: | (6aS,9R,10R,10aS)-9-ethyl-10-isocyano-6,6,9-trimethyl-5,6,6a,7,8,9,10,10a-octahydroindeno[2,1-b]indole, 2-OXOGLUTARIC ACID, CHLORIDE ION, ... | | Authors: | Mitchell, A.J, Boal, A.K. | | Deposit date: | 2016-03-11 | | Release date: | 2016-06-29 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural basis for halogenation by iron- and 2-oxo-glutarate-dependent enzyme WelO5.
Nat.Chem.Biol., 12, 2016
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5IQU
 | | WelO5 G166D variant bound to Fe(II), 2-oxoglutarate, and 12-epifischerindole U | | Descriptor: | (6aS,9R,10R,10aS)-9-ethyl-10-isocyano-6,6,9-trimethyl-5,6,6a,7,8,9,10,10a-octahydroindeno[2,1-b]indole, 2-OXOGLUTARIC ACID, FE (II) ION, ... | | Authors: | Mitchell, A.J, Maggiolo, A.O, Boal, A.K. | | Deposit date: | 2016-03-11 | | Release date: | 2016-06-29 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | Structural basis for halogenation by iron- and 2-oxo-glutarate-dependent enzyme WelO5.
Nat.Chem.Biol., 12, 2016
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5IQS
 | | WelO5 bound to Fe(II), Cl, and 2-oxoglutarate | | Descriptor: | 2-OXOGLUTARIC ACID, CHLORIDE ION, FE (II) ION, ... | | Authors: | Mitchell, A.J, Ananth, N, Boal, A.K. | | Deposit date: | 2016-03-11 | | Release date: | 2016-06-29 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural basis for halogenation by iron- and 2-oxo-glutarate-dependent enzyme WelO5.
Nat.Chem.Biol., 12, 2016
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6MP8
 | | X-ray crystal structure of VioC bound to Fe(II), D-arginine, and 2-oxoglutarate | | Descriptor: | 2-OXOGLUTARIC ACID, Alpha-ketoglutarate-dependent L-arginine hydroxylase, D-ARGININE, ... | | Authors: | Dunham, N.P, Boal, A.K. | | Deposit date: | 2018-10-05 | | Release date: | 2018-11-21 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.89 Å) | | Cite: | alpha-Amine Desaturation of d-Arginine by the Iron(II)- and 2-(Oxo)glutarate-Dependent l-Arginine 3-Hydroxylase, VioC.
Biochemistry, 57, 2018
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