6PSW
| Escherichia coli RNA polymerase promoter unwinding intermediate (TRPo) with TraR and rpsT P2 promoter | 分子名称: | CHAPSO, DNA (85-MER), DNA-directed RNA polymerase subunit alpha, ... | 著者 | Chen, J, Chiu, C.E, Campbell, E.A, Darst, S.A. | 登録日 | 2019-07-13 | 公開日 | 2020-03-25 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Stepwise Promoter Melting by Bacterial RNA Polymerase. Mol.Cell, 78, 2020
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1TH8
| Crystal Structures of the ADP and ATP bound forms of the Bacillus Anti-sigma factor SpoIIAB in complex with the Anti-anti-sigma SpoIIAA: inhibitory complex with ADP, crystal form II | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Anti-sigma F factor, Anti-sigma F factor antagonist, ... | 著者 | Masuda, S, Murakami, K.S, Wang, S, Olson, C.A, Donigian, J, Leon, F, Darst, S.A, Campbell, E.A. | 登録日 | 2004-06-01 | 公開日 | 2004-06-15 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal Structures of the ADP and ATP Bound Forms of the Bacillus Anti-sigma Factor SpoIIAB in Complex with the Anti-anti-sigma SpoIIAA. J.Mol.Biol., 340, 2004
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6XEZ
| Structure of SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... | 著者 | Chen, J, Malone, B, Llewellyn, E.C, Campbell, E.A, Darst, S.A. | 登録日 | 2020-06-14 | 公開日 | 2020-07-29 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex. Cell, 182, 2020
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2GBH
| NMR structure of stem region of helix-35 of 23S E.coli ribosomal RNA (residues 736-760) | 分子名称: | 5'-R(*(GMP)P*GP*GP*CP*UP*AP*AP*UP*GP*(PSU)P*UP*GP*AP*AP*AP*AP*AP*UP*UP*AP*GP*CP*CP*C)-3' | 著者 | Bax, A, Boisbouvier, J, Bryce, D, Grishaev, A, Jaroniec, C, Miclet, E, Nikonovicz, E, O'Neil-Cabello, E, Ying, J. | 登録日 | 2006-03-10 | 公開日 | 2006-04-11 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Measurement of five dipolar couplings from a single 3D NMR multiplet applied to the study of RNA dynamics. J.Am.Chem.Soc., 126, 2004
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4X8K
| Mycobacterium tuberculosis RbpA-SID in complex with SigmaA domain 2 | 分子名称: | 1,2-ETHANEDIOL, RNA polymerase sigma factor SigA, RNA polymerase-binding protein RbpA, ... | 著者 | Hubin, E.A, Flack, J.E, Tabib-Salazar, A, Paget, M.S, Darst, S.A, Campbell, E.A. | 登録日 | 2014-12-10 | 公開日 | 2015-06-03 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.202 Å) | 主引用文献 | Structural, functional, and genetic analyses of the actinobacterial transcription factor RbpA. Proc.Natl.Acad.Sci.USA, 112, 2015
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7RDZ
| SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC - apo class | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Helicase, MAGNESIUM ION, ... | 著者 | Chen, J, Malone, B, Campbell, E.A, Darst, S.A. | 登録日 | 2021-07-12 | 公開日 | 2021-11-24 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex. Nat.Struct.Mol.Biol., 29, 2022
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7RE3
| SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC dimer | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... | 著者 | Chen, J, Malone, B, Campbell, E.A, Darst, S.A. | 登録日 | 2021-07-12 | 公開日 | 2021-11-24 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.33 Å) | 主引用文献 | Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex. Nat.Struct.Mol.Biol., 29, 2022
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7RE1
| SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC (composite) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... | 著者 | Chen, J, Malone, B, Campbell, E.A, Darst, S.A. | 登録日 | 2021-07-12 | 公開日 | 2021-12-01 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.91 Å) | 主引用文献 | Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex. Nat.Struct.Mol.Biol., 29, 2022
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7RDY
| SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC - engaged class | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... | 著者 | Chen, J, Malone, B, Campbell, E.A, Darst, S.A. | 登録日 | 2021-07-12 | 公開日 | 2021-12-01 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex. Nat.Struct.Mol.Biol., 29, 2022
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7RE0
| SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC - swiveled class | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Helicase, ... | 著者 | Chen, J, Malone, B, Campbell, E.A, Darst, S.A. | 登録日 | 2021-07-12 | 公開日 | 2021-12-01 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex. Nat.Struct.Mol.Biol., 29, 2022
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7RDX
| SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC - open class | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... | 著者 | Chen, J, Malone, B, Campbell, E.A, Darst, S.A. | 登録日 | 2021-07-12 | 公開日 | 2021-11-24 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex. Nat.Struct.Mol.Biol., 29, 2022
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7RE2
| SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(1)-RTC | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... | 著者 | Chen, J, Malone, B, Campbell, E.A, Darst, S.A. | 登録日 | 2021-07-12 | 公開日 | 2021-12-01 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.17 Å) | 主引用文献 | Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex. Nat.Struct.Mol.Biol., 29, 2022
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6OUL
| Cryo-EM structure of Escherichia coli RNAP polymerase bound to rpsTP2 promoter DNA | 分子名称: | CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Chen, J, Chiu, C.E, Campbell, E.A, Darst, S.A. | 登録日 | 2019-05-04 | 公開日 | 2020-02-26 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | E. coliTraR allosterically regulates transcription initiation by altering RNA polymerase conformation. Elife, 8, 2019
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6P1K
| Cryo-EM structure of Escherichia coli sigma70 bound RNAP polymerase holoenzyme | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Chen, J, Chiu, C.E, Campbell, E.A, Darst, S.A. | 登録日 | 2019-05-20 | 公開日 | 2020-02-26 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4.05 Å) | 主引用文献 | E. coliTraR allosterically regulates transcription initiation by altering RNA polymerase conformation. Elife, 8, 2019
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5VI8
| Structure of a mycobacterium smegmatis transcription initiation complex with an upstream-fork promoter fragment | 分子名称: | 1,2-ETHANEDIOL, DNA (26-MER), DNA (31-MER), ... | 著者 | Hubin, E.A, Campbell, E.A, Darst, S.A. | 登録日 | 2017-04-14 | 公開日 | 2017-04-26 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.76 Å) | 主引用文献 | Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures. Nat Commun, 8, 2017
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4XAX
| Crystal structure of Thermus thermophilus CarD in complex with the Thermus aquaticus RNA polymerase beta1 domain | 分子名称: | 1,2-ETHANEDIOL, CarD, DNA-directed RNA polymerase subunit beta domain 1 | 著者 | Chen, J, Bae, B, Campbell, E.A, Darst, S.A. | 登録日 | 2014-12-15 | 公開日 | 2015-09-16 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.404 Å) | 主引用文献 | CarD uses a minor groove wedge mechanism to stabilize the RNA polymerase open promoter complex. Elife, 4, 2015
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6N57
| Cryo-EM structure of Escherichia coli RNAP polymerase bound with TraR in conformation I | 分子名称: | CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Chen, J, Chiu, C.E, Campbell, E.A, Darst, S.A. | 登録日 | 2018-11-21 | 公開日 | 2020-02-26 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | E. coliTraR allosterically regulates transcription initiation by altering RNA polymerase conformation. Elife, 8, 2019
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6N58
| Cryo-EM structure of Escherichia coli RNAP polymerase bound with TraR in conformation II | 分子名称: | CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Chen, J, Chiu, C.E, Campbell, E.A, Darst, S.A. | 登録日 | 2018-11-21 | 公開日 | 2020-02-26 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.78 Å) | 主引用文献 | E. coliTraR allosterically regulates transcription initiation by altering RNA polymerase conformation. Elife, 8, 2019
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4XAY
| Cycles of destabilization and repair underlie evolutionary transitions in enzymes | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase variant PTE-R8, ... | 著者 | Jackson, C.J, Campbell, E, Kaltenbach, M, Tokuriki, N. | 登録日 | 2014-12-16 | 公開日 | 2015-12-16 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | The role of protein dynamics in the evolution of new enzyme function. Nat.Chem.Biol., 12, 2016
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4XAZ
| Cycles of destabilization and repair underlie evolutionary transitions in enzymes | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Phosphotriesterase variant PTE-R18, ZINC ION | 著者 | Jackson, C.J, Campbell, E, Kaltenbach, M, Tokuriki, N. | 登録日 | 2014-12-16 | 公開日 | 2015-12-16 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | The role of protein dynamics in the evolution of new enzyme function. Nat.Chem.Biol., 12, 2016
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4XD4
| Phosphotriesterase variant E2b | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase variant PTE-R3, ... | 著者 | Jackson, C.J, Campbell, E, Kaltenbach, M, Tokuriki, N. | 登録日 | 2014-12-19 | 公開日 | 2015-12-23 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The role of protein dynamics in the evolution of new enzyme function. Nat.Chem.Biol., 12, 2016
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4XAG
| Cycles of destabilization and repair underlie the evolution of new enzyme function | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase variant PTE-R6, ... | 著者 | Jackson, C.J, Campbell, E, Kaltenbach, M, Tokuriki, N. | 登録日 | 2014-12-14 | 公開日 | 2015-12-16 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | The role of protein dynamics in the evolution of new enzyme function. Nat.Chem.Biol., 12, 2016
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4XD3
| Phosphotriesterase variant E3 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase variant PTE-E1, ... | 著者 | Jackson, C.J, Campbell, E, Kaltenbach, M, Tokuriki, N. | 登録日 | 2014-12-19 | 公開日 | 2015-12-23 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | 主引用文献 | The role of protein dynamics in the evolution of new enzyme function. Nat.Chem.Biol., 12, 2016
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4XD6
| Phosphotriesterase Variant E2a | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase variant PTE-E2, ... | 著者 | Jackson, C.J, Campbell, E, Kaltenbach, M, Tokuriki, N. | 登録日 | 2014-12-19 | 公開日 | 2015-12-23 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | The role of protein dynamics in the evolution of new enzyme function. Nat.Chem.Biol., 12, 2016
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4XAF
| Cycles of destabilization and repair underlie evolutionary transitions in enzymes | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase variant PTE-R1, ... | 著者 | Jackson, C.J, Campbell, E, Kaltenbach, M, Tokuriki, N. | 登録日 | 2014-12-14 | 公開日 | 2015-12-16 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | The role of protein dynamics in the evolution of new enzyme function. Nat.Chem.Biol., 12, 2016
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