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PDB: 39 results

5JID
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BU of 5jid by Molmil
Crystal Structure of Human Transthyretin in Complex with Perfluorooctanoic acid (PFOA)
Descriptor: SODIUM ION, Transthyretin, pentadecafluorooctanoic acid
Authors:Begum, A, Zhang, J, Olofsson, A, Andersson, P, Sauer-Eriksson, A.E.
Deposit date:2016-04-22
Release date:2016-10-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structure-Based Virtual Screening Protocol for in Silico Identification of Potential Thyroid Disrupting Chemicals Targeting Transthyretin.
Environ. Sci. Technol., 50, 2016
4QYA
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BU of 4qya by Molmil
Crystal structure of human transthyretin variant V30M in complex with luteolin
Descriptor: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one, SODIUM ION, Transthyretin
Authors:Begum, A, Olofsson, A, Sauer-Eriksson, A.E.
Deposit date:2014-07-24
Release date:2015-06-03
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The flavonoid luteolin, but not luteolin-7-o-glucoside, prevents a transthyretin mediated toxic response.
Plos One, 10, 2015
5BOJ
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BU of 5boj by Molmil
Crystal Structure of Human Transthyretin in Complex with Gemfibrozil
Descriptor: 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid, SODIUM ION, Transthyretin
Authors:Begum, A, Olofsson, A, Sauer-Eriksson, A.E.
Deposit date:2015-05-27
Release date:2015-08-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Enthalpic Forces Correlate with the Selectivity of Transthyretin-Stabilizing Ligands in Human Plasma.
J.Med.Chem., 58, 2015
4QXV
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CRYSTAL STRUCTURE of HUMAN TRANSTHYRETIN IN COMPLEX WITH LUTEOLIN AT 1.1 A RESOLUTION
Descriptor: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one, GLYCEROL, SODIUM ION, ...
Authors:Begum, A, Olofsson, A, Sauer-Eriksson, A.E.
Deposit date:2014-07-22
Release date:2015-06-03
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:The flavonoid luteolin, but not luteolin-7-o-glucoside, prevents a transthyretin mediated toxic response.
Plos One, 10, 2015
5HJG
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Crystal Structure of Human Transthyretin in Complex with Tetrabromobisphenol A (TBBPA)
Descriptor: 4,4'-propane-2,2-diylbis(2,6-dibromophenol), SODIUM ION, Transthyretin
Authors:Begum, A, Iakovleva, I, Brannstrom, K, Zhang, J, Andersson, P, Olofsson, A, Sauer-Eriksson, A.E.
Deposit date:2016-01-13
Release date:2016-05-04
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Tetrabromobisphenol A Is an Efficient Stabilizer of the Transthyretin Tetramer.
Plos One, 11, 2016
5EN3
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BU of 5en3 by Molmil
Crystal structure of human transthyretin in complex with luteolin-Cl at 1.25 A resolution
Descriptor: 2-[3,4-bis(oxidanyl)phenyl]-7-chloranyl-5-oxidanyl-chromen-4-one, GLYCEROL, SODIUM ION, ...
Authors:Begum, A, Nilsson, L, Olofsson, A, Sauer-Eriksson, A.E.
Deposit date:2015-11-09
Release date:2016-04-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Modifications of the 7-Hydroxyl Group of the Transthyretin Ligand Luteolin Provide Mechanistic Insights into Its Binding Properties and High Plasma Specificity.
Plos One, 11, 2016
5IHH
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BU of 5ihh by Molmil
Crystal structure of human transthyretin in complex with luteolin-MeO at 1.35 A resolution
Descriptor: 2-(3,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-4H-1-chromen-4-one, SODIUM ION, Transthyretin
Authors:Begum, A, Nilsson, L, Olofsson, A, Sauer-Eriksson, A.E.
Deposit date:2016-02-29
Release date:2016-04-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Modifications of the 7-Hydroxyl Group of the Transthyretin Ligand Luteolin Provide Mechanistic Insights into Its Binding Properties and High Plasma Specificity.
Plos One, 11, 2016
5F1R
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BU of 5f1r by Molmil
The Transcriptional Regulator PrfA from Listeria Monocytogenes in complex with a ring-fused 2-pyridone (C10)
Descriptor: (3~{R})-8-cyclopropyl-7-(naphthalen-1-ylmethyl)-5-oxidanylidene-2,3-dihydro-[1,3]thiazolo[3,2-a]pyridine-3-carboxylic acid, Listeriolysin regulatory protein
Authors:Begum, A, Grundstrom, C, Good, J.A.D, Andersson, C, ALmqvist, F, Johansson, J, Sauer, U.H, Sauer-Eriksson, A.E.
Deposit date:2015-11-30
Release date:2016-03-16
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Attenuating Listeria monocytogenes Virulence by Targeting the Regulatory Protein PrfA.
Cell Chem Biol, 23, 2016
4FN6
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BU of 4fn6 by Molmil
Structural Characterization of Thiaminase type II TenA from Staphylococcus aureus
Descriptor: ACETATE ION, GLYCEROL, thiaminase-2
Authors:Begum, A, Drebes, J, Perbandt, M, Wrenger, C, Betzel, C.
Deposit date:2012-06-19
Release date:2012-12-19
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Structural Characterization of Thiaminase type II TenA from Staphylococcus aureus
TO BE PUBLISHED
5JIM
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BU of 5jim by Molmil
Crystal Structure of Human Transthyretin in Complex with Perfluoroktansulfonsyra (PFOS)
Descriptor: SODIUM ION, Transthyretin, heptadecafluoro-1-octanesulfonic acid
Authors:Begum, A, Zhang, J, Olofsson, A, Andersson, P, Sauer-Eriksson, A.E.
Deposit date:2016-04-22
Release date:2016-10-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:Structure-Based Virtual Screening Protocol for in Silico Identification of Potential Thyroid Disrupting Chemicals Targeting Transthyretin.
Environ. Sci. Technol., 50, 2016
5JIQ
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BU of 5jiq by Molmil
Crystal Structure of Human Transthyretin in Complex with 2,2',4,4'-tetrahydroxybenzophenone (BP2)
Descriptor: GLYCEROL, SODIUM ION, Transthyretin, ...
Authors:Begum, A, Zhang, J, Olofsson, A, Andersson, P, Sauer-Eriksson, A.E.
Deposit date:2016-04-22
Release date:2016-10-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structure-Based Virtual Screening Protocol for in Silico Identification of Potential Thyroid Disrupting Chemicals Targeting Transthyretin.
Environ. Sci. Technol., 50, 2016
4GY7
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BU of 4gy7 by Molmil
Crystallographic structure analysis of urease from Jack bean (Canavalia ensiformis) at 1.49 A Resolution
Descriptor: 1,2-ETHANEDIOL, ACETONE, BETA-MERCAPTOETHANOL, ...
Authors:Begum, A, Banumathi, S, Choudhary, M.I, Betzel, C.
Deposit date:2012-09-05
Release date:2012-11-07
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.492 Å)
Cite:Crystallographic structure analysis of urease from Jack bean (Canavalia ensiformis) at 1.49 A Resolution
To be Published
4H9M
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BU of 4h9m by Molmil
The first Jack bean urease (Canavalia ensiformis) complex obtained at 1.52 resolution
Descriptor: 1,2-ETHANEDIOL, ACETOHYDROXAMIC ACID, NICKEL (II) ION, ...
Authors:Begum, A, Choudhary, M.I, Betzel, C.
Deposit date:2012-09-24
Release date:2012-10-24
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:The first Jack bean urease (Canavalia ensiformis) complex obtained at 1.52 resolution
TO BE PUBLISHED
6EUT
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BU of 6eut by Molmil
The Transcriptional Regulator PrfA from Listeria Monocytogenes in complex with a ring-fused 2-pyridone (KSK67)
Descriptor: (3~{R})-8-cyclopropyl-7-[(4-methylnaphthalen-1-yl)methyl]-5-oxidanylidene-2,3-dihydro-[1,3]thiazolo[3,2-a]pyridine-3-carboxylic acid, GLYCEROL, ISOPROPYL ALCOHOL, ...
Authors:Begum, A, Hall, M, Grundstrom, C, Kulen, M, Lindgren, M, Johansson, J, Almqvist, F, Sauer, U.H, Sauer-Eriksson, A.E.
Deposit date:2017-10-31
Release date:2018-05-02
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-Based Design of Inhibitors Targeting PrfA, the Master Virulence Regulator of Listeria monocytogenes.
J. Med. Chem., 61, 2018
6EUZ
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BU of 6euz by Molmil
The Transcriptional Regulator PrfA from Listeria Monocytogenes in complex with a ring-fused 2-pyridone (MK37)
Descriptor: (3~{R})-8-methoxy-7-(naphthalen-1-ylmethyl)-5-oxidanylidene-2,3-dihydro-[1,3]thiazolo[3,2-a]pyridine-3-carboxylic acid, ISOPROPYL ALCOHOL, Listeriolysin positive regulatory factor A, ...
Authors:Begum, A, Hall, M, Grundstrom, C, Kulen, M, Lindgren, M, Johansson, J, Almqvist, F, Sauer, U.H, Sauer-Eriksson, A.E.
Deposit date:2017-10-31
Release date:2018-05-02
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure-Based Design of Inhibitors Targeting PrfA, the Master Virulence Regulator of Listeria monocytogenes.
J. Med. Chem., 61, 2018
6EUU
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BU of 6euu by Molmil
The Transcriptional Regulator PrfA from Listeria Monocytogenes in complex with a ring-fused 2-pyridone (KSK29)
Descriptor: (3~{R})-8-cyclopropyl-5-oxidanylidene-7-(quinolin-3-ylmethyl)-2,3-dihydro-[1,3]thiazolo[3,2-a]pyridine-3-carboxylic acid, ISOPROPYL ALCOHOL, Listeriolysin positive regulatory factor A, ...
Authors:Begum, A, Hall, M, Grundstrom, C, Kulen, M, Lindgren, M, Johansson, J, Almqvist, F, Sauer, U.H, Sauer-Eriksson, A.E.
Deposit date:2017-10-31
Release date:2018-05-02
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure-Based Design of Inhibitors Targeting PrfA, the Master Virulence Regulator of Listeria monocytogenes.
J. Med. Chem., 61, 2018
6EV0
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BU of 6ev0 by Molmil
The Transcriptional Regulator PrfA from Listeria Monocytogenes in complex with a ring-fused 2-pyridone (AC129)
Descriptor: ISOPROPYL ALCOHOL, Listeriolysin regulatory protein, [(3~{R})-3-carboxy-7-(naphthalen-1-ylmethyl)-5-oxidanylidene-2,3-dihydro-[1,3]thiazolo[3,2-a]pyridin-8-yl]-dimethyl-azanium, ...
Authors:Begum, A, Hall, M, Grundstrom, C, Cairns, A.G, Kulen, M, Lindgren, M, Johansson, J, Almqvist, F, Sauer, U.H, Sauer-Eriksson, A.E.
Deposit date:2017-10-31
Release date:2018-05-02
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-Based Design of Inhibitors Targeting PrfA, the Master Virulence Regulator of Listeria monocytogenes.
J. Med. Chem., 61, 2018
7Q9N
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BU of 7q9n by Molmil
Transthyretin complexed with (E)-4-(2-(naphthalen-2-yl)vinyl)benzene-1,2-diol
Descriptor: 4-[(~{E})-2-naphthalen-2-ylethenyl]benzene-1,2-diol, Transthyretin
Authors:Derbyshire, D.J, Hammarstrom, P, von Castelmur, E, Begum, A.
Deposit date:2021-11-12
Release date:2022-11-23
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Transthyretin Binding Mode Dichotomy of Fluorescent trans -Stilbene Ligands.
Acs Chem Neurosci, 14, 2023
7Q9L
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BU of 7q9l by Molmil
Transthyretin complexed with (E)-4-(2-(naphthalen-1-yl)vinyl)benzene-1,2-diol
Descriptor: 4-[(~{E})-2-naphthalen-1-ylethenyl]benzene-1,2-diol, GLYCEROL, SODIUM ION, ...
Authors:Derbyshire, D.J, Hammarstrom, P, von Castelmur, E, Begum, A.
Deposit date:2021-11-12
Release date:2022-11-23
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Transthyretin Binding Mode Dichotomy of Fluorescent trans -Stilbene Ligands.
Acs Chem Neurosci, 14, 2023
7Q9O
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BU of 7q9o by Molmil
Complex of Transthyretin with resveratrol exhibits multiple binding modes
Descriptor: GLYCEROL, RESVERATROL, SODIUM ION, ...
Authors:Derbyshire, D.J, Hammarstrom, P, von Castelmur, E, Begum, A.
Deposit date:2021-11-12
Release date:2022-11-23
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Transthyretin Binding Mode Dichotomy of Fluorescent trans -Stilbene Ligands.
Acs Chem Neurosci, 14, 2023
8AWI
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BU of 8awi by Molmil
Crystal structure of Human Transthyretin at 1.15 Angstrom resolution
Descriptor: SODIUM ION, Transthyretin
Authors:Derbyshire, D.J, Hammarstrom, P, von Castelmur, E, Begum, A.
Deposit date:2022-08-29
Release date:2023-03-01
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Transthyretin Binding Mode Dichotomy of Fluorescent trans -Stilbene Ligands.
Acs Chem Neurosci, 14, 2023
5LEK
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BU of 5lek by Molmil
The Transcriptional Regulator PrfA-G145S mutant from Listeria Monocytogenes in complex with a 30-bp operator PrfA-box motif
Descriptor: DNA (30-MER), Listeriolysin regulatory protein
Authors:Hall, M, Grundstrom, C, Begum, A, Lindberg, M, Sauer, U.H, Almqvist, F, Johansson, J, Sauer-Eriksson, A.E.
Deposit date:2016-06-29
Release date:2016-12-07
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for glutathione-mediated activation of the virulence regulatory protein PrfA in Listeria.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
5LRR
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BU of 5lrr by Molmil
The Transcriptional Regulator PrfA from Listeria Monocytogenes in complex with glutathione
Descriptor: GLUTATHIONE, HYDROGENPHOSPHATE ION, Listeriolysin positive regulatory factor A, ...
Authors:Hall, M, Grundstrom, C, Begum, A, Lindberg, M, Sauer, U.H, Almqvist, F, Johansson, J, Sauer-Eriksson, A.E.
Deposit date:2016-08-19
Release date:2016-12-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.171 Å)
Cite:Structural basis for glutathione-mediated activation of the virulence regulatory protein PrfA in Listeria.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
1U33
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BU of 1u33 by Molmil
In situ extension as an approach for identifying novel alpha-amylase inhibitors
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4'-O-METHYL-MALTOSYL-ALPHA (1,4)-(Z, 3S,4S,5R,6R)-3,4,5-TRIHYDROXY-6-HYDROXYMETHYL-PIPERIDIN-2-ONE, ...
Authors:Numao, S, Li, C, Damager, I, Wrodnigg, T.M, Begum, A, Overall, C.M, Brayer, G.D, Withers, S.G.
Deposit date:2004-07-20
Release date:2004-09-07
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:In Situ Extension as an Approach for Identifying Novel alpha-Amylase Inhibitors.
J.Biol.Chem., 279, 2004
1U30
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BU of 1u30 by Molmil
In situ extension as an approach for identifying novel alpha-amylase inhibitors, structure containing maltosyl-alpha (1,4)-D-gluconhydroximo-1,5-lactam
Descriptor: (2S,3S,4R,5R)-6-(HYDROXYAMINO)-2-(HYDROXYMETHYL)-2,3,4,5-TETRAHYDROPYRIDINE-3,4,5-TRIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-amylase, ...
Authors:Numao, S, Li, C, Damager, I, Wrodnigg, T.M, Begum, A, Overall, C.M, Brayer, G.D, Withers, S.G.
Deposit date:2004-07-20
Release date:2004-09-07
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:In Situ Extension as an Approach for Identifying Novel alpha-Amylase Inhibitors.
J.Biol.Chem., 279, 2004

 

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