1U30

In situ extension as an approach for identifying novel alpha-amylase inhibitors, structure containing maltosyl-alpha (1,4)-D-gluconhydroximo-1,5-lactam

Summary for 1U30

Entry DOI	10.2210/pdb1u30/pdb
Related	1U2Y 1U33
Descriptor	Alpha-amylase, pancreatic, 2-acetamido-2-deoxy-beta-D-glucopyranose, MALTOSYL-ALPHA (1,4)-(Z,3S,4S,5R,6R)-3,4,5-TRIHYDROXY-6-HYDROXYMETHYL-PIPERIDIN-2-ONE OXIME, ... (7 entities in total)
Functional Keywords	glycosidase, human pancreatic alpha-amylase, acarbose, inhibitor, glucosidase, enzyme mechanism, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	56936.67
Authors	Numao, S.,Li, C.,Damager, I.,Wrodnigg, T.M.,Begum, A.,Overall, C.M.,Brayer, G.D.,Withers, S.G. (deposition date: 2004-07-20, release date: 2004-09-07, Last modification date: 2020-11-11)
Primary citation	Numao, S.,Damager, I.,Li, C.,Wrodnigg, T.M.,Begum, A.,Overall, C.M.,Brayer, G.D.,Withers, S.G. In Situ Extension as an Approach for Identifying Novel alpha-Amylase Inhibitors. J.Biol.Chem., 279:48282-48291, 2004 Cited by PubMed: 15304511 DOI: 10.1074/jbc.M406804200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation