1GSN
 
 | | HUMAN GLUTATHIONE REDUCTASE MODIFIED BY DINITROSOGLUTATHIONE | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE, GLUTATHIONE REDUCTASE, ... | | Authors: | Becker, K, Savvides, S.N, Keese, M, Schirmer, R.H, Karplus, P.A. | | Deposit date: | 1998-02-21 | | Release date: | 1998-05-27 | | Last modified: | 2011-12-07 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Enzyme inactivation through sulfhydryl oxidation by physiologic NO-carriers.
Nat.Struct.Biol., 5, 1998
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1DNC
 | | HUMAN GLUTATHIONE REDUCTASE MODIFIED BY DIGLUTATHIONE-DINITROSO-IRON | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE, GLUTATHIONE REDUCTASE, ... | | Authors: | Becker, K, Savvides, S.N, Keese, M, Schirmer, R.H, Karplus, P.A. | | Deposit date: | 1998-02-20 | | Release date: | 1998-05-27 | | Last modified: | 2011-12-07 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Enzyme inactivation through sulfhydryl oxidation by physiologic NO-carriers.
Nat.Struct.Biol., 5, 1998
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2AAQ
 | | Crystal Structure Analysis of the human Glutahione Reductase, complexed with GoPI | | Descriptor: | 2-(2-PHENYL-3-PYRIDIN-2-YL-4,5,6,7-TETRAHYDRO-2H-ISOPHOSPHINDOL-1-YL)PYRIDINE, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | | Authors: | Urig, S, Fritz-Wolf, K, Reau, R, Herold-Mende, C, Toth, K, Davioud-Charvet, E, Becker, K. | | Deposit date: | 2005-07-14 | | Release date: | 2006-04-04 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Undressing of Phosphine Gold(I) Complexes as Irreversible Inhibitors of Human Disulfide Reductases.
Angew.Chem.Int.Ed.Engl., 45, 2006
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2AAW
 | | Studies on ligand binding and enzyme inhibition of Plasmodium falciparum glutathione S-transferase | | Descriptor: | 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, L-TREITOL, S-HEXYLGLUTATHIONE, ... | | Authors: | Hiller, N, Fritz-Wolf, K, Deponte, M, Wende, W, Zimmermann, H, Becker, K. | | Deposit date: | 2005-07-14 | | Release date: | 2006-01-10 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Plasmodium falciparum glutathione S-transferase--structural and mechanistic studies on ligand binding and enzyme inhibition.
Protein Sci., 15, 2006
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1OKT
 | | X-ray Structure of Glutathione S-Transferase from the Malarial Parasite Plasmodium falciparum | | Descriptor: | FORMIC ACID, GLUTATHIONE S-TRANSFERASE | | Authors: | Fritz-Wolf, K, Becker, A, Rahlfs, s, Harwaldt, P, Schirmer, R.H, Kabsch, W, Becker, K. | | Deposit date: | 2003-07-29 | | Release date: | 2003-11-20 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | X-Ray Structure of Glutathione S-Transferase from the Malarial Parasite Plasmodium Falciparum
Proc.Natl.Acad.Sci.USA, 100, 2003
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3LG0
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5LM3
 | | Plasmodium falciparum nicotinic acid mononucleotide adenylyltransferase complexed with APC | | Descriptor: | 1,2-ETHANEDIOL, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, Nicotinate-nucleotide adenylyltransferase | | Authors: | Bathke, J, Fritz-Wolf, K, Rahlfs, S, Brandstaether, C, Burkhardt, A, Becker, K. | | Deposit date: | 2016-07-29 | | Release date: | 2016-11-30 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural and Functional Characterization of Plasmodium falciparum Nicotinic Acid Mononucleotide Adenylyltransferase.
J. Mol. Biol., 428, 2016
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4J56
 | | Structure of Plasmodium falciparum thioredoxin reductase-thioredoxin complex | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Thioredoxin, Thioredoxin reductase 2 | | Authors: | Fritz-Wolf, K, Jortzik, E, Stumpf, M, Preuss, J, Iozef, R, Rahlfs, S, Becker, K. | | Deposit date: | 2013-02-08 | | Release date: | 2013-07-10 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.371 Å) | | Cite: | Crystal Structure of the Plasmodium falciparum Thioredoxin Reductase-Thioredoxin Complex.
J.Mol.Biol., 425, 2013
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4J57
 | | Structure of Plasmodium falciparum thioredoxin reductase-thioredoxin complex | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Thioredoxin, ... | | Authors: | Fritz-Wolf, K, Jortzik, E, Stumpf, M, Preuss, J, Iozef, R, Rahlfs, S, Becker, K. | | Deposit date: | 2013-02-08 | | Release date: | 2013-07-10 | | Last modified: | 2017-11-22 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal Structure of the Plasmodium falciparum Thioredoxin Reductase-Thioredoxin Complex.
J.Mol.Biol., 425, 2013
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7PCZ
 | | Functional and structural characterization of redox sensitive superfolder green fluorescent protein and variants | | Descriptor: | ETHANOL, GLYCEROL, Green fluorescent protein | | Authors: | Fritz-Wolf, K, Heimsch, K.C, Schuh, A.K, Becker, K. | | Deposit date: | 2021-08-04 | | Release date: | 2022-02-16 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Structure and Function of Redox-Sensitive Superfolder Green Fluorescent Protein Variant.
Antioxid.Redox Signal., 37, 2022
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7PCA
 | | Functional and structural characterization of redox sensitive superfolder green fluorescent protein and variants | | Descriptor: | ETHANOL, FORMAMIDE, GLYCEROL, ... | | Authors: | Fritz-Wolf, K, Heimsch, K.C, Schuh, A.K, Becker, K. | | Deposit date: | 2021-08-03 | | Release date: | 2022-02-16 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.05 Å) | | Cite: | Structure and Function of Redox-Sensitive Superfolder Green Fluorescent Protein Variant.
Antioxid.Redox Signal., 37, 2022
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7PD0
 | | Functional and structural characterization of redox sensitive superfolder green fluorescent protein and variants | | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Green fluorescent protein, ... | | Authors: | Fritz-Wolf, K, Heimsch, K.C, Schuh, A.K, Becker, K. | | Deposit date: | 2021-08-04 | | Release date: | 2022-02-16 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure and Function of Redox-Sensitive Superfolder Green Fluorescent Protein Variant.
Antioxid.Redox Signal., 37, 2022
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3R3J
 | | Kinetic and structural characterization of Plasmodium falciparum glutamate dehydrogenase 2 | | Descriptor: | Glutamate dehydrogenase | | Authors: | Zocher, K, Fritz-Wolf, K, Kehr, S, Rahlfs, S, Becker, K. | | Deposit date: | 2011-03-16 | | Release date: | 2012-03-07 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Biochemical and structural characterization of Plasmodium falciparum glutamate dehydrogenase 2.
Mol.Biochem.Parasitol., 183, 2012
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5LLT
 | | Plasmodium falciparum nicotinic acid mononucleotide adenylyltransferase complexed with NaAD | | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, NICOTINIC ACID ADENINE DINUCLEOTIDE, ... | | Authors: | Bathke, J, Fritz-Wolf, K, Brandstaedter, C, Rahlfs, S, Becker, K. | | Deposit date: | 2016-07-28 | | Release date: | 2016-11-30 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural and Functional Characterization of Plasmodium falciparum Nicotinic Acid Mononucleotide Adenylyltransferase.
J. Mol. Biol., 428, 2016
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3QFB
 | | Crystal structure of the human thioredoxin reductase-thioredoxin complex | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Thioredoxin, ... | | Authors: | Fritz-Wolf, K, Kehr, S, Stumpf, M, Rahlfs, S, Becker, K. | | Deposit date: | 2011-01-21 | | Release date: | 2011-07-27 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structure of the human thioredoxin reductase-thioredoxin complex
Nat Commun, 2, 2011
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3NTJ
 | | Redox regulation of Plasmodium falciparum ornithine delta-aminotransferase | | Descriptor: | Ornithine aminotransferase, SULFATE ION | | Authors: | Fritz-Wolf, K, Jortzik, E, Stumpf, M, Becker, K. | | Deposit date: | 2010-07-05 | | Release date: | 2010-08-04 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Redox regulation of Plasmodium falciparum ornithine delta-aminotransferase
J.Mol.Biol., 402, 2010
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3QFA
 | | Crystal structure of the human thioredoxin reductase-thioredoxin complex | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Thioredoxin, ... | | Authors: | Fritz-Wolf, K, Kehr, S, Stumpf, M, Rahlfs, S, Becker, K. | | Deposit date: | 2011-01-21 | | Release date: | 2011-07-27 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of the human thioredoxin reductase-thioredoxin complex
Nat Commun, 2, 2011
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6FQY
 | | Plasmodium falciparum 6-phosphogluconate dehydrogenase in its apo form, in complex with its cofactor NADP+ and in complex with its substrate 6-phosphogluconate | | Descriptor: | 1,2-ETHANEDIOL, 6-phosphogluconate dehydrogenase, decarboxylating, ... | | Authors: | Fritz-Wolf, K, Haeussler, K, Reichmann, M, Rahlfs, S, Becker, K. | | Deposit date: | 2018-02-15 | | Release date: | 2018-08-22 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Characterization of Plasmodium falciparum 6-Phosphogluconate Dehydrogenase as an Antimalarial Drug Target.
J. Mol. Biol., 430, 2018
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6FQX
 | | Plasmodium falciparum 6-phosphogluconate dehydrogenase in its apo form, in complex with its cofactor NADP+ and in complex with its substrate 6-phosphogluconate | | Descriptor: | 2-(2-ETHOXYETHOXY)ETHANOL, 6-phosphogluconate dehydrogenase, decarboxylating, ... | | Authors: | Fritz-Wolf, K, Haeussler, K, Reichmann, M, Rahlfs, S, Becker, K. | | Deposit date: | 2018-02-15 | | Release date: | 2018-08-22 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Characterization of Plasmodium falciparum 6-Phosphogluconate Dehydrogenase as an Antimalarial Drug Target.
J. Mol. Biol., 430, 2018
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8C79
 | | Crystal structure of Leishmania donovani 6-Phosphogluconate Dehydrogenase complexed with NADPH | | Descriptor: | 6-phosphogluconate dehydrogenase, decarboxylating, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Fritz-Wolf, K, Berneburg, I, Rahlfs, S, Becker, K. | | Deposit date: | 2023-01-13 | | Release date: | 2023-05-24 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structure of Leishmania donovani 6-Phosphogluconate Dehydrogenase and Inhibition by Phosphine Gold(I) Complexes: A Potential Approach to Leishmaniasis Treatment.
Int J Mol Sci, 24, 2023
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6FQZ
 | | Plasmodium falciparum 6-phosphogluconate dehydrogenase in its apo form, in complex with its cofactor NADP+ and in complex with its substrate 6-phosphogluconate | | Descriptor: | 6-PHOSPHOGLUCONIC ACID, 6-phosphogluconate dehydrogenase, decarboxylating, ... | | Authors: | Fritz-Wolf, K, Haeussler, K, Reichmann, M, Rahlfs, S, Becker, K. | | Deposit date: | 2018-02-15 | | Release date: | 2018-08-22 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Characterization of Plasmodium falciparum 6-Phosphogluconate Dehydrogenase as an Antimalarial Drug Target.
J. Mol. Biol., 430, 2018
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7ZZI
 | | Plasmodium falciparum hexokinase complexed with glucose and citrate | | Descriptor: | 1,2-ETHANEDIOL, CITRIC ACID, Phosphotransferase, ... | | Authors: | Fritz-Wolf, K, Dillenberger, M, Rahlfs, S, Becker, K. | | Deposit date: | 2022-05-25 | | Release date: | 2023-08-30 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural Analysis of Plasmodium falciparum Hexokinase Provides Novel Information about Catalysis Due to a Plasmodium -Specific Insertion.
Int J Mol Sci, 24, 2023
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1K4Q
 | | Human Glutathione Reductase Inactivated by Peroxynitrite | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Glutathione Reductase | | Authors: | Savvides, S.N, Scheiwein, M, Boehme, C.C, Arteel, G.E, Karplus, P.A, Becker, K, Schirmer, R.H. | | Deposit date: | 2001-10-08 | | Release date: | 2002-01-30 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of the antioxidant enzyme glutathione reductase inactivated by peroxynitrite.
J.Biol.Chem., 277, 2002
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7AOJ
 | | Plasmoredoxin, a redox-active protein unique for malaria parasites | | Descriptor: | GLYCEROL, Plasmoredoxin | | Authors: | Fritz-Wolf, K, Bathke, J, Rahlfs, S, Becker, K. | | Deposit date: | 2020-10-14 | | Release date: | 2022-04-13 | | Last modified: | 2024-06-19 | | Method: | X-RAY DIFFRACTION (1.63 Å) | | Cite: | Crystal structure of plasmoredoxin, a redox-active protein unique for malaria parasites.
Curr Res Struct Biol, 4, 2022
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7AOO
 | | Plasmoredoxin, a redox-active protein unique for malaria parasites | | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, HEXAETHYLENE GLYCOL, ... | | Authors: | Fritz-Wolf, K, Bathke, J, Rahlfs, S, Becker, K. | | Deposit date: | 2020-10-14 | | Release date: | 2022-04-13 | | Last modified: | 2024-06-19 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystal structure of plasmoredoxin, a redox-active protein unique for malaria parasites.
Curr Res Struct Biol, 4, 2022
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