1I3E
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![BU of 1i3e by Molmil](/molmil-images/mine/1i3e) | HUMAN AZIDO-MET HEMOGLOBIN BART'S (GAMMA4) | 分子名称: | AZIDE ION, HEMOGLOBIN GAMMA CHAINS, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Kidd, R.D, Baker, H.M, Mathews, A.J, Brittain, T, Baker, E.N. | 登録日 | 2001-02-15 | 公開日 | 2001-09-12 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Oligomerization and ligand binding in a homotetrameric hemoglobin: two high-resolution crystal structures of hemoglobin Bart's (gamma(4)), a marker for alpha-thalassemia. Protein Sci., 10, 2001
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2YPP
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![BU of 2ypp by Molmil](/molmil-images/mine/2ypp) | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase in complex with 3 tyrosine molecules | 分子名称: | CHLORIDE ION, GLYCEROL, MANGANESE (II) ION, ... | 著者 | Blackmore, N.J, Reichau, S, Jiao, W, Hutton, R.D, Baker, E.N, Jameson, G.B, Parker, E.J. | 登録日 | 2012-10-31 | 公開日 | 2013-01-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Three Sites and You are Out: Ternary Synergistic Allostery Controls Aromatic Aminoacid Biosynthesis in Mycobacterium Tuberculosis. J.Mol.Biol., 425, 2013
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2YPO
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![BU of 2ypo by Molmil](/molmil-images/mine/2ypo) | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase with phenylalanine bound in only one site | 分子名称: | GLYCEROL, MANGANESE (II) ION, PHENYLALANINE, ... | 著者 | Blackmore, N.J, Reichau, S, Jiao, W, Hutton, R.D, Baker, E.N, Jameson, G.B, Parker, E.J. | 登録日 | 2012-10-31 | 公開日 | 2013-01-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Three Sites and You are Out: Ternary Synergistic Allostery Controls Aromatic Aminoacid Biosynthesis in Mycobacterium Tuberculosis. J.Mol.Biol., 425, 2013
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3B2M
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3B4Y
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![BU of 3b4y by Molmil](/molmil-images/mine/3b4y) | FGD1 (Rv0407) from Mycobacterium tuberculosis | 分子名称: | CITRATE ANION, COENZYME F420, PROBABLE F420-DEPENDENT GLUCOSE-6-PHOSPHATE DEHYDROGENASE FGD1 | 著者 | Bashiri, G, Squire, C.J, Moreland, N.M, Baker, E.N, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2007-10-25 | 公開日 | 2008-04-22 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Crystal structures of F420-dependent glucose-6-phosphate dehydrogenase FGD1 involved in the activation of the anti-tuberculosis drug candidate PA-824 reveal the basis of coenzyme and substrate binding J.Biol.Chem., 283, 2008
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3BIZ
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![BU of 3biz by Molmil](/molmil-images/mine/3biz) | Wee1 kinase complex with inhibitor PD331618 | 分子名称: | 4-(2-chlorophenyl)-8-[3-(dimethylamino)propoxy]-9-hydroxy-6-methylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione, CHLORIDE ION, Wee1-like protein kinase | 著者 | Squire, C.J, Dickson, J.M, Ivanovic, I, Baker, E.N. | 登録日 | 2007-12-02 | 公開日 | 2007-12-25 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases. Bioorg.Med.Chem.Lett., 18, 2008
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1I3D
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![BU of 1i3d by Molmil](/molmil-images/mine/1i3d) | HUMAN CARBONMONOXY HEMOGLOBIN BART'S (GAMMA4) | 分子名称: | CARBON MONOXIDE, HEMOGLOBIN GAMMA CHAINS, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Kidd, R.D, Baker, H.M, Mathews, A.J, Brittain, T, Baker, E.N. | 登録日 | 2001-02-15 | 公開日 | 2001-09-12 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Oligomerization and ligand binding in a homotetrameric hemoglobin: two high-resolution crystal structures of hemoglobin Bart's (gamma(4)), a marker for alpha-thalassemia. Protein Sci., 10, 2001
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3BI6
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![BU of 3bi6 by Molmil](/molmil-images/mine/3bi6) | Wee1 kinase complex with inhibitor PD352396 | 分子名称: | 4-(2-chlorophenyl)-9-hydroxy-6-methyl-1,3-dioxo-N-(2-pyrrolidin-1-ylethyl)pyrrolo[3,4-g]carbazole-8-carboxamide, CHLORIDE ION, Wee1-like protein kinase | 著者 | Squire, C.J, Dickson, J.M, Ivanovic, I, Baker, E.N. | 登録日 | 2007-11-29 | 公開日 | 2007-12-18 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases. Bioorg.Med.Chem.Lett., 18, 2008
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3C8N
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2Z2W
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![BU of 2z2w by Molmil](/molmil-images/mine/2z2w) | Human Wee1 kinase complexed with inhibitor PF0335770 | 分子名称: | CHLORIDE ION, GLYCEROL, N-[4-(2-CHLOROPHENYL)-1,3-DIOXO-1,2,3,6-TETRAHYDROPYRROLO[3,4-C]CARBAZOL-9-YL]FORMAMIDE, ... | 著者 | Squire, C.J, Baker, E.N. | 登録日 | 2007-05-29 | 公開日 | 2008-05-06 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Synthesis and Structure-Activity Relationships of 9-Amino-4-(2-chlorophenyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones and Related Formamides as Inhibitors of the Wee1 and Chk1 Checkpoint Kinases To be Published
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3CQE
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![BU of 3cqe by Molmil](/molmil-images/mine/3cqe) | Wee1 kinase complex with inhibitor PD074291 | 分子名称: | 8-bromo-4-(2-chlorophenyl)-N-(2-hydroxyethyl)-6-methyl-1,3-dioxo-1,2,3,6-tetrahydropyrrolo[3,4-e]indole-7-carboxamide, CHLORIDE ION, GLYCEROL, ... | 著者 | Squire, C.J, Baker, E.N. | 登録日 | 2008-04-02 | 公開日 | 2009-02-24 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural Determinants of Wee1 Inhibitor Selectivity To be Published
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3CR0
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![BU of 3cr0 by Molmil](/molmil-images/mine/3cr0) | Wee1 kinase complex with inhibitor PD259_809 | 分子名称: | 4-(2-chlorophenyl)-8-(2-hydroxyethyl)-6-methylpyrrolo[3,4-e]indole-1,3(2H,6H)-dione, CHLORIDE ION, GLYCEROL, ... | 著者 | Squire, C.J, Baker, E.N. | 登録日 | 2008-04-03 | 公開日 | 2009-02-24 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural determinants of Wee1 inhibitor selectivity To be Published
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1JQF
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![BU of 1jqf by Molmil](/molmil-images/mine/1jqf) | Human Transferrin N-Lobe Mutant H249Q | 分子名称: | CARBONATE ION, FE (III) ION, POTASSIUM ION, ... | 著者 | Baker, H.M, Mason, A.B, He, Q.-Y, MacGillivray, R.T.A, Baker, E.N. | 登録日 | 2001-08-06 | 公開日 | 2001-10-17 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Ligand variation in the transferrin family: the crystal structure of the H249Q mutant of the human transferrin N-lobe as a model for iron binding in insect transferrins. Biochemistry, 40, 2001
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1JMY
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![BU of 1jmy by Molmil](/molmil-images/mine/1jmy) | Truncated Recombinant Human Bile Salt Stimulated Lipase | 分子名称: | BILE-SALT-ACTIVATED LIPASE, SULFATE ION | 著者 | Moore, S.A, Kingston, R.L, Loomes, K.M, Hernell, O, Blackberg, L, Baker, H.M, Baker, E.N. | 登録日 | 2001-07-20 | 公開日 | 2001-08-08 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | The structure of truncated recombinant human bile salt-stimulated lipase reveals bile salt-independent conformational flexibility at the active-site loop and provides insights into heparin binding. J.Mol.Biol., 312, 2001
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1RJN
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![BU of 1rjn by Molmil](/molmil-images/mine/1rjn) | The Crystal Structure of MenB (Rv0548c) from Mycobacterium tuberculosis in Complex with the CoA Portion of Naphthoyl CoA | 分子名称: | 3-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]PROPANE-1-SULFONIC ACID, COENZYME A, menB | 著者 | Johnston, J.M, Arcus, V.L, Baker, E.N, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2003-11-19 | 公開日 | 2004-11-30 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure of naphthoate synthase (MenB) from Mycobacterium tuberculosis in both native and product-bound forms. Acta Crystallogr.,Sect.D, 61, 2005
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1RJM
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![BU of 1rjm by Molmil](/molmil-images/mine/1rjm) | Crystal Structure of MenB (Rv0548c) from Mycobacterium tuberculosis | 分子名称: | 3-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]PROPANE-1-SULFONIC ACID, MenB | 著者 | Johnston, J.M, Arcus, V.L, Baker, E.N, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2003-11-19 | 公開日 | 2004-11-30 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structure of naphthoate synthase (MenB) from Mycobacterium tuberculosis in both native and product-bound forms. Acta Crystallogr.,Sect.D, 61, 2005
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1V8P
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![BU of 1v8p by Molmil](/molmil-images/mine/1v8p) | Crystal structure of PAE2754 from Pyrobaculum aerophilum | 分子名称: | CHLORIDE ION, hypothetical protein PAE2754 | 著者 | Arcus, V.L, Backbro, K, Roos, A, Daniel, E.L, Baker, E.N. | 登録日 | 2004-01-12 | 公開日 | 2004-02-10 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | 主引用文献 | Distant structural homology leads to the functional characterization of an archaeal PIN domain as an exonuclease J.Biol.Chem., 279, 2004
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1V8O
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![BU of 1v8o by Molmil](/molmil-images/mine/1v8o) | Crystal Structure of PAE2754 from Pyrobaculum aerophilum | 分子名称: | CHLORIDE ION, hypothetical protein PAE2754 | 著者 | Arcus, V.L, Backbro, K, Roos, A, Daniel, E.L, Baker, E.N. | 登録日 | 2004-01-12 | 公開日 | 2004-02-10 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Distant structural homology leads to the functional characterization of an archaeal PIN domain as an exonuclease J.Biol.Chem., 279, 2004
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1SR9
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![BU of 1sr9 by Molmil](/molmil-images/mine/1sr9) | Crystal Structure of LeuA from Mycobacterium tuberculosis | 分子名称: | 2-isopropylmalate synthase, 3-METHYL-2-OXOBUTANOIC ACID, CHLORIDE ION, ... | 著者 | Koon, N, Squire, C.J, Baker, E.N. | 登録日 | 2004-03-22 | 公開日 | 2004-05-18 | 最終更新日 | 2017-10-11 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of LeuA from Mycobacterium tuberculosis, a key enzyme in leucine biosynthesis Proc.Natl.Acad.Sci.USA, 101, 2004
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4IDS
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4IDM
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4IHI
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4JDC
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4K8W
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![BU of 4k8w by Molmil](/molmil-images/mine/4k8w) | An arm-swapped dimer of the S. pyogenes pilin specific assembly factor SipA | 分子名称: | 1,2-ETHANEDIOL, ETHANOL, LepA | 著者 | Young, P.G, Kang, H.J, Baker, E.N. | 登録日 | 2013-04-19 | 公開日 | 2013-06-26 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | An arm-swapped dimer of the Streptococcus pyogenes pilin specific assembly factor SipA. J.Struct.Biol., 183, 2013
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4IJ1
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![BU of 4ij1 by Molmil](/molmil-images/mine/4ij1) | Bianthranilate-like analogue bound to anthranilate phosphoribosyltransferase (AnPRT; trpD) in absence of substrates. | 分子名称: | 2,2'-iminodibenzoic acid, Anthranilate phosphoribosyltransferase, GLYCEROL, ... | 著者 | Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2012-12-20 | 公開日 | 2013-12-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis. Chembiochem, 15, 2014
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