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PDB: 265 件

1I3E
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HUMAN AZIDO-MET HEMOGLOBIN BART'S (GAMMA4)
分子名称: AZIDE ION, HEMOGLOBIN GAMMA CHAINS, PROTOPORPHYRIN IX CONTAINING FE
著者Kidd, R.D, Baker, H.M, Mathews, A.J, Brittain, T, Baker, E.N.
登録日2001-02-15
公開日2001-09-12
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Oligomerization and ligand binding in a homotetrameric hemoglobin: two high-resolution crystal structures of hemoglobin Bart's (gamma(4)), a marker for alpha-thalassemia.
Protein Sci., 10, 2001
2YPP
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3-deoxy-D-arabino-heptulosonate 7-phosphate synthase in complex with 3 tyrosine molecules
分子名称: CHLORIDE ION, GLYCEROL, MANGANESE (II) ION, ...
著者Blackmore, N.J, Reichau, S, Jiao, W, Hutton, R.D, Baker, E.N, Jameson, G.B, Parker, E.J.
登録日2012-10-31
公開日2013-01-09
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Three Sites and You are Out: Ternary Synergistic Allostery Controls Aromatic Aminoacid Biosynthesis in Mycobacterium Tuberculosis.
J.Mol.Biol., 425, 2013
2YPO
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3-deoxy-D-arabino-heptulosonate 7-phosphate synthase with phenylalanine bound in only one site
分子名称: GLYCEROL, MANGANESE (II) ION, PHENYLALANINE, ...
著者Blackmore, N.J, Reichau, S, Jiao, W, Hutton, R.D, Baker, E.N, Jameson, G.B, Parker, E.J.
登録日2012-10-31
公開日2013-01-09
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Three Sites and You are Out: Ternary Synergistic Allostery Controls Aromatic Aminoacid Biosynthesis in Mycobacterium Tuberculosis.
J.Mol.Biol., 425, 2013
3B2M
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Crystal Structure of the Major Pilin from Streptococcus pyogenes
分子名称: Putative uncharacterized protein SPy0128
著者Kang, H.J, Coulibaly, F, Proft, T, Baker, E.N.
登録日2007-10-18
公開日2007-12-18
最終更新日2021-11-10
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献Stabilizing isopeptide bonds revealed in gram-positive bacterial pilus structure.
Science, 318, 2007
3B4Y
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FGD1 (Rv0407) from Mycobacterium tuberculosis
分子名称: CITRATE ANION, COENZYME F420, PROBABLE F420-DEPENDENT GLUCOSE-6-PHOSPHATE DEHYDROGENASE FGD1
著者Bashiri, G, Squire, C.J, Moreland, N.M, Baker, E.N, TB Structural Genomics Consortium (TBSGC)
登録日2007-10-25
公開日2008-04-22
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal structures of F420-dependent glucose-6-phosphate dehydrogenase FGD1 involved in the activation of the anti-tuberculosis drug candidate PA-824 reveal the basis of coenzyme and substrate binding
J.Biol.Chem., 283, 2008
3BIZ
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Wee1 kinase complex with inhibitor PD331618
分子名称: 4-(2-chlorophenyl)-8-[3-(dimethylamino)propoxy]-9-hydroxy-6-methylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione, CHLORIDE ION, Wee1-like protein kinase
著者Squire, C.J, Dickson, J.M, Ivanovic, I, Baker, E.N.
登録日2007-12-02
公開日2007-12-25
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases.
Bioorg.Med.Chem.Lett., 18, 2008
1I3D
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HUMAN CARBONMONOXY HEMOGLOBIN BART'S (GAMMA4)
分子名称: CARBON MONOXIDE, HEMOGLOBIN GAMMA CHAINS, PROTOPORPHYRIN IX CONTAINING FE
著者Kidd, R.D, Baker, H.M, Mathews, A.J, Brittain, T, Baker, E.N.
登録日2001-02-15
公開日2001-09-12
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Oligomerization and ligand binding in a homotetrameric hemoglobin: two high-resolution crystal structures of hemoglobin Bart's (gamma(4)), a marker for alpha-thalassemia.
Protein Sci., 10, 2001
3BI6
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Wee1 kinase complex with inhibitor PD352396
分子名称: 4-(2-chlorophenyl)-9-hydroxy-6-methyl-1,3-dioxo-N-(2-pyrrolidin-1-ylethyl)pyrrolo[3,4-g]carbazole-8-carboxamide, CHLORIDE ION, Wee1-like protein kinase
著者Squire, C.J, Dickson, J.M, Ivanovic, I, Baker, E.N.
登録日2007-11-29
公開日2007-12-18
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases.
Bioorg.Med.Chem.Lett., 18, 2008
3C8N
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Crystal structure of apo-FGD1 from Mycobacterium tuberculosis
分子名称: Probable F420-dependent glucose-6-phosphate dehydrogenase FGD1
著者Bashiri, G, Squire, C.J, Moreland, N.J, Baker, E.N.
登録日2008-02-12
公開日2008-04-22
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structures of F420-dependent glucose-6-phosphate dehydrogenase FGD1 involved in the activation of the anti-tuberculosis drug candidate PA-824 reveal the basis of coenzyme and substrate binding.
J.Biol.Chem., 283, 2008
2Z2W
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Human Wee1 kinase complexed with inhibitor PF0335770
分子名称: CHLORIDE ION, GLYCEROL, N-[4-(2-CHLOROPHENYL)-1,3-DIOXO-1,2,3,6-TETRAHYDROPYRROLO[3,4-C]CARBAZOL-9-YL]FORMAMIDE, ...
著者Squire, C.J, Baker, E.N.
登録日2007-05-29
公開日2008-05-06
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献Synthesis and Structure-Activity Relationships of 9-Amino-4-(2-chlorophenyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones and Related Formamides as Inhibitors of the Wee1 and Chk1 Checkpoint Kinases
To be Published
3CQE
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Wee1 kinase complex with inhibitor PD074291
分子名称: 8-bromo-4-(2-chlorophenyl)-N-(2-hydroxyethyl)-6-methyl-1,3-dioxo-1,2,3,6-tetrahydropyrrolo[3,4-e]indole-7-carboxamide, CHLORIDE ION, GLYCEROL, ...
著者Squire, C.J, Baker, E.N.
登録日2008-04-02
公開日2009-02-24
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural Determinants of Wee1 Inhibitor Selectivity
To be Published
3CR0
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BU of 3cr0 by Molmil
Wee1 kinase complex with inhibitor PD259_809
分子名称: 4-(2-chlorophenyl)-8-(2-hydroxyethyl)-6-methylpyrrolo[3,4-e]indole-1,3(2H,6H)-dione, CHLORIDE ION, GLYCEROL, ...
著者Squire, C.J, Baker, E.N.
登録日2008-04-03
公開日2009-02-24
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural determinants of Wee1 inhibitor selectivity
To be Published
1JQF
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BU of 1jqf by Molmil
Human Transferrin N-Lobe Mutant H249Q
分子名称: CARBONATE ION, FE (III) ION, POTASSIUM ION, ...
著者Baker, H.M, Mason, A.B, He, Q.-Y, MacGillivray, R.T.A, Baker, E.N.
登録日2001-08-06
公開日2001-10-17
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Ligand variation in the transferrin family: the crystal structure of the H249Q mutant of the human transferrin N-lobe as a model for iron binding in insect transferrins.
Biochemistry, 40, 2001
1JMY
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BU of 1jmy by Molmil
Truncated Recombinant Human Bile Salt Stimulated Lipase
分子名称: BILE-SALT-ACTIVATED LIPASE, SULFATE ION
著者Moore, S.A, Kingston, R.L, Loomes, K.M, Hernell, O, Blackberg, L, Baker, H.M, Baker, E.N.
登録日2001-07-20
公開日2001-08-08
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The structure of truncated recombinant human bile salt-stimulated lipase reveals bile salt-independent conformational flexibility at the active-site loop and provides insights into heparin binding.
J.Mol.Biol., 312, 2001
1RJN
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BU of 1rjn by Molmil
The Crystal Structure of MenB (Rv0548c) from Mycobacterium tuberculosis in Complex with the CoA Portion of Naphthoyl CoA
分子名称: 3-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]PROPANE-1-SULFONIC ACID, COENZYME A, menB
著者Johnston, J.M, Arcus, V.L, Baker, E.N, TB Structural Genomics Consortium (TBSGC)
登録日2003-11-19
公開日2004-11-30
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure of naphthoate synthase (MenB) from Mycobacterium tuberculosis in both native and product-bound forms.
Acta Crystallogr.,Sect.D, 61, 2005
1RJM
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Crystal Structure of MenB (Rv0548c) from Mycobacterium tuberculosis
分子名称: 3-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]PROPANE-1-SULFONIC ACID, MenB
著者Johnston, J.M, Arcus, V.L, Baker, E.N, TB Structural Genomics Consortium (TBSGC)
登録日2003-11-19
公開日2004-11-30
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structure of naphthoate synthase (MenB) from Mycobacterium tuberculosis in both native and product-bound forms.
Acta Crystallogr.,Sect.D, 61, 2005
1V8P
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Crystal structure of PAE2754 from Pyrobaculum aerophilum
分子名称: CHLORIDE ION, hypothetical protein PAE2754
著者Arcus, V.L, Backbro, K, Roos, A, Daniel, E.L, Baker, E.N.
登録日2004-01-12
公開日2004-02-10
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.52 Å)
主引用文献Distant structural homology leads to the functional characterization of an archaeal PIN domain as an exonuclease
J.Biol.Chem., 279, 2004
1V8O
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Crystal Structure of PAE2754 from Pyrobaculum aerophilum
分子名称: CHLORIDE ION, hypothetical protein PAE2754
著者Arcus, V.L, Backbro, K, Roos, A, Daniel, E.L, Baker, E.N.
登録日2004-01-12
公開日2004-02-10
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Distant structural homology leads to the functional characterization of an archaeal PIN domain as an exonuclease
J.Biol.Chem., 279, 2004
1SR9
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Crystal Structure of LeuA from Mycobacterium tuberculosis
分子名称: 2-isopropylmalate synthase, 3-METHYL-2-OXOBUTANOIC ACID, CHLORIDE ION, ...
著者Koon, N, Squire, C.J, Baker, E.N.
登録日2004-03-22
公開日2004-05-18
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of LeuA from Mycobacterium tuberculosis, a key enzyme in leucine biosynthesis
Proc.Natl.Acad.Sci.USA, 101, 2004
4IDS
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BU of 4ids by Molmil
Crystal structure of the Delta-pyrroline-5-carboxylate dehydrogenase from Mycobacterium tuberculosis
分子名称: Delta-1-pyrroline-5-carboxylate dehydrogenase
著者Lagautriere, T, Bashiri, G, Baker, E.N.
登録日2012-12-13
公開日2013-12-18
最終更新日2014-04-16
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Characterization of the proline-utilization pathway in Mycobacterium tuberculosis through structural and functional studies.
Acta Crystallogr.,Sect.D, 70, 2014
4IDM
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BU of 4idm by Molmil
Crystal structure of the Delta-pyrroline-5-carboxylate dehydrogenase from Mycobacterium tuberculosis
分子名称: Delta-1-pyrroline-5-carboxylate dehydrogenase
著者Lagautriere, T, Bashiri, G, Baker, E.N.
登録日2012-12-12
公開日2013-12-18
最終更新日2014-04-16
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Characterization of the proline-utilization pathway in Mycobacterium tuberculosis through structural and functional studies.
Acta Crystallogr.,Sect.D, 70, 2014
4IHI
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BU of 4ihi by Molmil
Crystal structure of the Delta-pyrroline-5-carboxylate dehydrogenase from Mycobacterium tuberculosis bound with NAD
分子名称: Delta-1-pyrroline-5-carboxylate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Lagautriere, T, Bashiri, G, Baker, E.N.
登録日2012-12-18
公開日2013-12-18
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Characterization of the proline-utilization pathway in Mycobacterium tuberculosis through structural and functional studies.
Acta Crystallogr.,Sect.D, 70, 2014
4JDC
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BU of 4jdc by Molmil
Crystal structure of the Delta-pyrroline-5-carboxylate dehydrogenase from Mycobacterium tuberculosis
分子名称: 1-pyrroline-5-carboxylate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Lagautriere, T, Bashiri, G, Baker, E.N.
登録日2013-02-24
公開日2013-12-18
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Characterization of the proline-utilization pathway in Mycobacterium tuberculosis through structural and functional studies.
Acta Crystallogr.,Sect.D, 70, 2014
4K8W
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An arm-swapped dimer of the S. pyogenes pilin specific assembly factor SipA
分子名称: 1,2-ETHANEDIOL, ETHANOL, LepA
著者Young, P.G, Kang, H.J, Baker, E.N.
登録日2013-04-19
公開日2013-06-26
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献An arm-swapped dimer of the Streptococcus pyogenes pilin specific assembly factor SipA.
J.Struct.Biol., 183, 2013
4IJ1
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Bianthranilate-like analogue bound to anthranilate phosphoribosyltransferase (AnPRT; trpD) in absence of substrates.
分子名称: 2,2'-iminodibenzoic acid, Anthranilate phosphoribosyltransferase, GLYCEROL, ...
著者Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
登録日2012-12-20
公開日2013-12-25
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis.
Chembiochem, 15, 2014

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