2Z2W

Human Wee1 kinase complexed with inhibitor PF0335770

Summary for 2Z2W

Entry DOI	10.2210/pdb2z2w/pdb
Related	1X8B 2IN6 2IO6
Descriptor	Wee1-like protein kinase, CHLORIDE ION, N-[4-(2-CHLOROPHENYL)-1,3-DIOXO-1,2,3,6-TETRAHYDROPYRROLO[3,4-C]CARBAZOL-9-YL]FORMAMIDE, ... (5 entities in total)
Functional Keywords	wee1 kinase, inhibitor complex, transferase
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P30291
Total number of polymer chains	1
Total formula weight	32701.98
Authors	Squire, C.J.,Baker, E.N. (deposition date: 2007-05-29, release date: 2008-05-06, Last modification date: 2023-11-15)
Primary citation	Squire, C.J.,Baker, E.N. Synthesis and Structure-Activity Relationships of 9-Amino-4-(2-chlorophenyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones and Related Formamides as Inhibitors of the Wee1 and Chk1 Checkpoint Kinases To be Published,
Experimental method	X-RAY DIFFRACTION (2.22 Å)

Structure validation