1X8B

Structure of human Wee1A kinase: kinase domain complexed with inhibitor PD0407824

Summary for 1X8B

Entry DOI	10.2210/pdb1x8b/pdb
Descriptor	Wee1-like protein kinase, MAGNESIUM ION, 9-HYDROXY-4-PHENYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE, ... (4 entities in total)
Functional Keywords	kinase, cell cycle, wee1, transferase
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P30291
Total number of polymer chains	1
Total formula weight	32861.95
Authors	Squire, C.J.,Dickson, J.M.,Ivanovic, I.,Baker, E.N. (deposition date: 2004-08-17, release date: 2005-06-07, Last modification date: 2024-03-13)
Primary citation	Squire, C.J.,Dickson, J.M.,Ivanovic, I.,Baker, E.N. Structure and inhibition of the human cell cycle checkpoint kinase, Wee1A kinase: an atypical tyrosine kinase with a key role in CDK1 regulation Structure, 13:541-550, 2005 Cited by PubMed: 15837193 DOI: 10.1016/j.str.2004.12.017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.81 Å)

Structure validation