1X8B
Structure of human Wee1A kinase: kinase domain complexed with inhibitor PD0407824
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Wee1-like protein kinase | polymer | 289 | 32485.0 | 1 | UniProt (P30291) Pfam (PF00069) | Homo sapiens (human) | WEE1hu |
| 2 | B, C (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 3 | D (A) | 9-HYDROXY-4-PHENYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE | non-polymer | 328.3 | 1 | Chemie (824) | |||
| 4 | E (A) | water | water | 18.0 | 144 | Chemie (HOH) |
Sequence modifications
A: 291 - 575 (UniProt: P30291)
| PDB | External Database | Details |
|---|---|---|
| Gly 287 | - | cloning artifact |
| Ala 288 | - | cloning artifact |
| Met 289 | - | cloning artifact |
| Gly 290 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32485.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 376.9 | |
| All* | Total formula weight | 32861.9 |
