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PDB: 3971 件
5F0A
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BU of 5f0a by Molmil
CRYSTAL STRUCTURE OF PVX_084705 WITH BOUND 1-tert-butyl-3-(3-chlorophenoxy)-1H-pyrazolo[3,4-d]pyrimidin-4-amine INHIBITOR
分子名称: 1-tert-butyl-3-(3-chlorophenoxy)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, cGMP-dependent protein kinase, putative
著者Walker, J.R, Wernimont, A.K, He, H, Seitova, A, Loppnau, P, Sibley, L.D, Graslund, S, Hutchinson, A, Bountra, C, Weigelt, J, Edwards, A.M, Arrowsmith, C.H, Hui, R, El Bakkouri, M, Structural Genomics Consortium (SGC)
登録日2015-11-27
公開日2015-12-16
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献CRYSTAL STRUCTURE OF PVX_084705 WITH BOUND INHIBITOR
To be published
6Y43
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Fibrinogen-like globe domain of human ANGPTL6
分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Angiopoietin-related protein 6, ...
著者Coker, J.A, Krojer, T, Mutisya, J.M, Arrowsmith, C.H, Bountra, C, Midwood, K.S, Yue, W.W, Marsden, B.D, Structural Genomics Consortium (SGC)
登録日2020-02-19
公開日2020-03-04
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Fibrinogen-like globe domain of human ANGPTL6
To Be Published
7AV8
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BU of 7av8 by Molmil
Crystal Structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in space group P21212
分子名称: PH-interacting protein
著者Krojer, T, Talon, R, Fairhead, M, Szykowska, A, Burgess-Brown, N.A, Brennan, P.E, Arrowsmith, C.H, Edwards, A.M, Bountra, C, von Delft, F, Structural Genomics Consortium (SGC)
登録日2020-11-04
公開日2021-01-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Crystal Structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in space group P21212
To Be Published
6YIM
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BU of 6yim by Molmil
Crystal structure of the CREBBP bromodomain in complex with a benzo-diazepine ligand
分子名称: (4~{R})-~{N}-[3-(7-methoxy-3,4-dihydro-2~{H}-quinolin-1-yl)propyl]-4-methyl-2-oxidanylidene-1,3,4,5-tetrahydro-1,5-benzodiazepine-6-carboxamide, CREBBP
著者Picaud, S, Brand, M, Tobias, K, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Conway, S, Filippakopoulos, P.
登録日2020-04-01
公開日2020-04-15
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.23 Å)
主引用文献Crystal structure of the CREBBP bromodomain in complex with a benzo-diazepine ligand
To Be Published
6MLC
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BU of 6mlc by Molmil
PHD6 domain of MLL3 in complex with histone H4
分子名称: GLYCEROL, Histone H4, Histone-lysine N-methyltransferase 2C, ...
著者Dong, A, Liu, Y, Qin, S, Lei, M, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
登録日2018-09-27
公開日2018-10-24
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.
Nat Commun, 10, 2019
5JJX
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Crystal structure of the HAT domain of sart3
分子名称: CHLORIDE ION, Squamous cell carcinoma antigen recognized by T-cells 3, UNKNOWN ATOM OR ION
著者DONG, A, ZHANG, Q, TEMPEL, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, TONG, Y, Structural Genomics Consortium (SGC)
登録日2016-04-25
公開日2016-05-04
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of the HAT domain of sart3
to be published
5J3U
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BU of 5j3u by Molmil
Co-crystal structure of the regulatory domain of Toxoplasma gondii PKA with cAMP
分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, GLYCEROL, Protein Kinase A
著者El Bakkouri, M, Walker, J.R, Tempel, W, Loppnau, P, Graslund, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Hui, R, Lin, L, Structural Genomics Consortium (SGC)
登録日2016-03-31
公開日2016-04-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Co-crystal structure of the regulatory domain of Toxoplasma gondii PKA with cAMP
To Be Published
3KCI
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BU of 3kci by Molmil
The third RLD domain of HERC2
分子名称: Probable E3 ubiquitin-protein ligase HERC2
著者Walker, J.R, Qiu, L, Vesterberg, A, Weigelt, J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S.
登録日2009-10-21
公開日2009-11-03
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure of the Third RLD Domain of Herc2
To be Published
6YIJ
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BU of 6yij by Molmil
Crystal structure of the CREBBP bromodomain in complex with a benzo-diazepine ligand
分子名称: (4~{R})-6-[(~{E})-5-(7-methoxy-3,4-dihydro-2~{H}-quinolin-1-yl)pent-1-enyl]-4-methyl-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one, CREBBP
著者Picaud, S, Brand, M, Tobias, K, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Conway, S, Filippakopoulos, P.
登録日2020-04-01
公開日2020-04-15
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of the CREBBP bromodomain in complex with a benzo-diazepine ligand
To Be Published
6YIL
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Crystal structure of the CREBBP bromodomain in complex with a tetrahydroquinoxaline ligand
分子名称: (3~{R})-~{N}-[3-(3,4-dihydro-2~{H}-quinolin-1-yl)-2,2-bis(fluoranyl)propyl]-3-methyl-2-oxidanylidene-3,4-dihydro-1~{H}-quinoxaline-5-carboxamide, CREBBP
著者Picaud, S, Brand, M, Tobias, K, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Conway, S, Filippakopoulos, P.
登録日2020-04-01
公開日2020-04-15
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.22 Å)
主引用文献Crystal structure of the CREBBP bromodomain in complex with a tetrahydroquinoxaline ligand
To Be Published
5JJZ
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BU of 5jjz by Molmil
Chromo domain of human Chromodomain Protein, Y-Like 2
分子名称: Chromodomain Y-like protein 2, LYS-LYS-LYS-ALA-ARG-MLY-SER-ALA-GLY-ALA-ALA-LYS-TYR
著者DONG, A, DOMBROVSKI, L, LOPPNAU, P, TEMPEL, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, MIN, J, WU, H, Structural Genomics Consortium (SGC)
登録日2016-04-25
公開日2016-05-25
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The crystal structure of CDYL2 domain of human CDYL2 protein
to be published
6WNX
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BU of 6wnx by Molmil
FBXW11-SKP1 in complex with a pSer33/pSer37 Beta-Catenin peptide
分子名称: Catenin beta-1, F-box/WD repeat-containing protein 11, GLYCEROL, ...
著者Ivanochko, D, Edwards, A.M, Bountra, C, Arrowsmith, C.H, Boettcher, J, Structural Genomics Consortium (SGC)
登録日2020-04-23
公開日2020-05-06
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献FBXW11-SKP1 in complex with a pSer33/pSer37 Beta-Catenin peptide
To Be Published
5MQ1
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BU of 5mq1 by Molmil
Crystal structure of the BRD7 bromodomain in complex with BI-9564
分子名称: 1,2-ETHANEDIOL, 4-[4-[(dimethylamino)methyl]-2,5-dimethoxy-phenyl]-2-methyl-2,7-naphthyridin-1-one, Bromodomain-containing protein 7, ...
著者Diaz-Saez, L, Martin, L.J, Panagakou, I, Picaud, S, Krojer, T, von Delft, F, Knapp, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Huber, K, Structural Genomics Consortium (SGC)
登録日2016-12-19
公開日2018-01-17
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal structure of the BRD7 bromodomain in complex with BI-9564
To Be Published
6C2F
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BU of 6c2f by Molmil
MBD2 in complex with methylated DNA
分子名称: 12-mer DNA, Methyl-CpG-binding domain protein 2, UNKNOWN ATOM OR ION
著者Liu, K, Xu, C, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium, Structural Genomics Consortium (SGC)
登録日2018-01-08
公開日2018-02-14
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献MBD2 in complex with methylated DNA
to be published
6Y7L
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BU of 6y7l by Molmil
Structure of the BRD9 bromodomain and TP-472
分子名称: 3-(6-acetylpyrrolo[1,2-a]pyrimidin-8-yl)-N-cyclopropyl-4-methylbenzamide, Bromodomain-containing protein 9
著者Diaz-Saez, L, Krojer, T, Picaud, S, von Delft, F, Filippakopoulos, P, Arrowsmith, C.H, Edwards, A, Bountra, C, Huber, K.V.M.
登録日2020-03-01
公開日2021-03-31
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure of the BRD9 bromodomain and compound 2
To Be Published
6Y7K
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BU of 6y7k by Molmil
Structure of the BRD9 bromodomain and compound 27
分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 9, SODIUM ION, ...
著者Diaz-Saez, L, Krojer, T, Picaud, S, von Delft, F, Filippakopoulos, P, Arrowsmith, C.H, Edwards, A, Bountra, C, Huber, K.V.M.
登録日2020-03-01
公開日2021-03-31
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Structure of the BRD9 bromodomain
To Be Published
5DWS
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BU of 5dws by Molmil
Crystal Structure of ITCH WW3 domain in complex with TXNIP peptide
分子名称: E3 ubiquitin-protein ligase Itchy homolog, UNKNOWN ATOM OR ION, txnip
著者Liu, Y, Tempel, W, Dong, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
登録日2015-09-22
公開日2015-10-14
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Crystal Structure of ITCH WW3 domain in complex with TXNIP peptide
to be published
5DZD
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BU of 5dzd by Molmil
Crystal Structure of WW4 domain of ITCH in complex with TXNIP peptide
分子名称: E3 ubiquitin-protein ligase Itchy homolog, Thioredoxin-interacting protein, UNKNOWN ATOM OR ION
著者Liu, Y, Tempel, W, Dong, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
登録日2015-09-25
公開日2015-10-14
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献Crystal Structure of WW4 domain of ITCH in complex with TXNIP peptide
To be Published
6HRL
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BU of 6hrl by Molmil
Crystal structure of the Kelch domain of human KLHL17
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Kelch-like protein 17, ...
著者Chen, Z, Williams, E, Sorrell, F.J, Newman, J.A, Shrestha, L, Burgess-Brown, N, von Delft, F, Arrowsmith, F, Edwards, C.H, Bountra, C, Bullock, A.N.
登録日2018-09-27
公開日2018-10-17
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal structure of the Kelch domain of human KLHL17
To Be Published
5EPJ
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BU of 5epj by Molmil
Crystal Structure of chromodomain of CBX7 in complex with inhibitor UNC3866
分子名称: Chromobox protein homolog 7, UNKNOWN ATOM OR ION, peptide-like inhibitor UNC3866
著者Liu, Y, Tempel, W, Walker, J.R, Stuckey, J.I, Dickson, B.M, James, L.I, Frye, S.V, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
登録日2015-11-11
公開日2015-12-16
最終更新日2019-11-27
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal Structure of chromodomain of CBX7 in complex with inhibitor UNC3866
to be published
3S95
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Crystal structure of the human LIMK1 kinase domain in complex with staurosporine
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ...
著者Beltrami, A, Chaikuad, A, Daga, N, Elkins, J.M, Mahajan, P, Savitsky, P, Vollmar, M, Krojer, T, Muniz, J.R.C, Fedorov, O, Allerston, C.K, Yue, W.W, Gileadi, O, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Bullock, A, Structural Genomics Consortium (SGC)
登録日2011-05-31
公開日2011-07-06
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Crystal structure of the human LIMK1 kinase domain in complex with staurosporine
To be Published
3T7L
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Crystal structure of the FYVE domain of endofin (ZFYVE16) at 1.1A resolution
分子名称: 1,2-ETHANEDIOL, ZINC ION, Zinc finger FYVE domain-containing protein 16
著者Chaikuad, A, Williams, E, Guo, K, Sanvitale, C, Berridge, G, Krojer, T, Muniz, J.R.C, Canning, P, Phillips, C, Shrestha, A, von Delft, F, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A, Structural Genomics Consortium (SGC)
登録日2011-07-30
公開日2011-08-31
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.09 Å)
主引用文献Crystal structure of the FYVE domain of endofin (ZFYVE16) at 1.1A resolution
To be Published
5H9M
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BU of 5h9m by Molmil
Crystal structure of siah2 SBD domain
分子名称: CHLORIDE ION, E3 ubiquitin-protein ligase SIAH2, PENTAETHYLENE GLYCOL, ...
著者Dong, A, Zhang, Q, Walker, J.R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Tong, Y, Structural Genomics Consortium (SGC)
登録日2015-12-28
公開日2016-02-17
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.761 Å)
主引用文献Crystal structure of siah2 SBD domain
to be published
7OQZ
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BU of 7oqz by Molmil
Cryo-EM structure of human TMEM45A
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Transmembrane protein 45A
著者Grieben, M, Pike, A.C.W, Evans, A, Shrestha, L, Venkaya, S, Mukhopadhyay, S.M.M, Moreira, T, Chalk, R, MacLean, E.M, Marsden, B.D, Burgess-Brown, N.A, Bountra, C, Carpenter, E.P.
登録日2021-06-04
公開日2021-06-16
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.27 Å)
主引用文献CryoEM structure of human TMEM45A
To Be Published
6Z36
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Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2118
分子名称: 1,2-ETHANEDIOL, 4-methyl-3-(4-piperidin-4-ylphenyl)-5-(3,4,5-trimethoxyphenyl)pyridine, AMMONIUM ION, ...
著者Adamson, R.J, Williams, E.P, Smil, D, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.N.
登録日2020-05-19
公開日2020-05-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.37 Å)
主引用文献Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2118
To Be Published

222415

件を2024-07-10に公開中

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