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PDB: 1215 件

2FLB
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Discovery of a Novel Hydroxy Pyrazole Based Factor IXa Inhibitor
分子名称: 2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE, Coagulation factor VII, Tissue factor
著者Katz, B.A.
登録日2006-01-05
公開日2006-04-04
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Discovery of novel hydroxy pyrazole based factor IXa inhibitor.
Bioorg.Med.Chem.Lett., 16, 2006
2FLR
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Novel 5-Azaindole Factor VIIa Inhibitors
分子名称: Coagulation factor VII, Tissue factor, [2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA
著者Riggs, J.R, Hu, H, Kolesnikov, A, Tong, Z, Leahy, E.M, Wesson, K.E, Shrader, W.D, Vijaykumar, D, Wahl, T.A, Sprengeler, P.A, Green, M.J, Yu, C, Katz, B.A, Young, W.B.
登録日2006-01-06
公開日2007-01-23
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Novel 5-azaindole factor VIIa inhibitors.
Bioorg.Med.Chem.Lett., 16, 2006
2FX4
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Bovine trypsin bound by 4-piperidinebutyrate to make acylenzyme complex
分子名称: 4-PIPERIDINEBUTYRATE, CALCIUM ION, trypsin
著者Katz, B.A.
登録日2006-02-03
公開日2006-02-14
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structure-guided design of Peptide-based tryptase inhibitors.
Biochemistry, 45, 2006
2H2R
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Crystal structure of the human CD23 Lectin domain, apo form
分子名称: Low affinity immunoglobulin epsilon Fc receptor (Lymphocyte IgE receptor) (Fc-epsilon-RII)(Immunoglobulin E-binding factor) (CD23 antigen)
著者Wurzburg, B.A.
登録日2006-05-19
公開日2006-06-20
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural Changes in the Lectin Domain of CD23, the Low-Affinity IgE Receptor, upon Calcium Binding.
Structure, 14, 2006
2FSY
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Bacteriophage HK97 Pepsin-treated Expansion Intermediate IV
分子名称: major capsid protein
著者Gan, L, Speir, J.A, Conway, J.F, Lander, G, Cheng, N, Firek, B.A, Hendrix, R.W, Duda, R.L, Liljas, L, Johnson, J.E.
登録日2006-01-23
公開日2006-02-07
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Capsid Conformational Sampling in HK97 Maturation Visualized by X-Ray Crystallography and Cryo-EM.
Structure, 14, 2006
2FX6
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bovine trypsin complexed with 2-aminobenzamidazole
分子名称: 2H-BENZOIMIDAZOL-2-YLAMINE, CALCIUM ION, Trypsin
著者Katz, B.A.
登録日2006-02-03
公開日2006-02-14
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献Structure-guided design of Peptide-based tryptase inhibitors.
Biochemistry, 45, 2006
2FRP
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Bacteriophage HK97 Expansion Intermediate IV
分子名称: Major capsid protein
著者Gan, L, Speir, J.A, Conway, J.F, Lander, G, Cheng, N, Firek, B.A, Hendrix, R.W, Duda, R.L, Liljas, L, Johnson, J.E.
登録日2006-01-19
公開日2006-02-07
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (7.5 Å)
主引用文献Capsid Conformational Sampling in HK97 Maturation Visualized by X-Ray Crystallography and Cryo-EM.
Structure, 14, 2006
2FWW
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human beta-tryptase II complexed with 4-piperidinebutyrate to make acylenzyme
分子名称: 4-PIPERIDINEBUTYRATE, Tryptase beta-2
著者Katz, B.A.
登録日2006-02-03
公開日2006-02-14
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structure-guided design of Peptide-based tryptase inhibitors.
Biochemistry, 45, 2006
2FT1
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Bacteriophage HK97 Head II
分子名称: major capsid protein
著者Gan, L, Speir, J.A, Conway, J.F, Lander, G, Cheng, N, Firek, B.A, Hendrix, R.W, Duda, R.L, Liljas, L, Johnson, J.E.
登録日2006-01-23
公開日2006-02-07
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.9 Å)
主引用文献Capsid Conformational Sampling in HK97 Maturation Visualized by X-Ray Crystallography and Cryo-EM.
Structure, 14, 2006
2FS3
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Bacteriophage HK97 K169Y Head I
分子名称: Major capsid protein
著者Gan, L, Speir, J.A, Conway, J.F, Lander, G, Cheng, N, Firek, B.A, Hendrix, R.W, Duda, R.L, Liljas, L, Johnson, J.E.
登録日2006-01-20
公開日2006-02-07
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (4.2 Å)
主引用文献Capsid Conformational Sampling in HK97 Maturation Visualized by X-Ray Crystallography and Cryo-EM.
Structure, 14, 2006
2GSJ
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cDNA cloning and 1.75A crystal structure determination of PPL2, a novel chimerolectin from Parkia platycephala seeds exhibiting endochitinolytic activity
分子名称: SULFATE ION, protein PPL-2
著者Cavada, B.S, Moreno, F.B, da Rocha, B.A, de Azevedo Jr, W.F, Castellon, R.E.R, Goersch, G.V, Nagano, C.S, de Souza, E.P, Nascimento, K.S, Radis-Baptista, G, Delatorre, P, Leroy, Y, Toyama, M.H, Pinto, V.P, Sampaio, A.H, Barettino, D, Debray, H, Calvete, J.J, Sanz, L.
登録日2006-04-26
公開日2007-03-13
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献cDNA cloning and 1.75 A crystal structure determination of PPL2, an endochitinase and N-acetylglucosamine-binding hemagglutinin from Parkia platycephala seeds
Febs J., 273, 2006
2H2T
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CD23 Lectin domain, Calcium 2+-bound
分子名称: CALCIUM ION, Low affinity immunoglobulin epsilon Fc receptor (Lymphocyte IgE receptor) (Fc-epsilon-RII) (Immunoglobulin E-binding factor) (CD23 antigen)
著者Wurzburg, B.A.
登録日2006-05-19
公開日2006-06-20
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Structural Changes in the Lectin Domain of CD23, the Low-Affinity IgE Receptor, upon Calcium Binding.
Structure, 14, 2006
2CWM
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Native Crystal Structure of NO releasing inductive lectin from seeds of the Canavalia maritima (ConM)
分子名称: CALCIUM ION, MANGANESE (II) ION, lectin
著者Cavada, B.S, De Azevedo Jr, W.F, Assreuy, A.M.S, Criddle, D.N, Gadelha, C.A.A, Delatorre, P, Souza, E.P, Rocha, B.A.M, Santi-Gadelha, T, Moreno, F.B.M.B.
登録日2005-06-22
公開日2006-01-17
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Native crystal structure of a nitric oxide-releasing lectin from the seeds of Canavalia maritima
J.Struct.Biol., 152, 2005
2CY6
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Crystal structure of ConM in complex with trehalose and maltose
分子名称: CALCIUM ION, Lectin, MANGANESE (II) ION, ...
著者Cavada, B.S, Azevedo Jr, W.F, Delatorre, P, Rocha, B.A.M, Souza, E.P, Gadelha, C.A.A.
登録日2005-07-05
公開日2006-06-13
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of a lectin from Canavalia maritima (ConM) in complex with trehalose and maltose reveals relevant mutation in ConA-like lectins
J.Struct.Biol., 154, 2006
2CYF
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The Crystal Structure of Canavalia Maritima Lectin (ConM) in Complex with Trehalose and Maltose
分子名称: CALCIUM ION, Lectin, MANGANESE (II) ION, ...
著者Delatorre, P, Rocha, B.A.M, Sousa, E.P, Gadelha, C.A.A, Azevedo Jr, W.F, Cavada, B.S.
登録日2005-07-06
公開日2006-06-13
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of a lectin from Canavalia maritima (ConM) in complex with trehalose and maltose reveals relevant mutation in ConA-like lectins
J.Struct.Biol., 154, 2006
2HYU
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Human Annexin A2 with heparin tetrasaccharide bound
分子名称: 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Annexin A2, CALCIUM ION
著者Shao, C, Head, J.F, Seaton, B.A.
登録日2006-08-07
公開日2006-09-05
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Crystallographic Analysis of Calcium-dependent Heparin Binding to Annexin A2.
J.Biol.Chem., 281, 2006
2HYW
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Human Annexin A2 with Calcium bound
分子名称: Annexin A2, CALCIUM ION
著者Shao, C, Head, J.F, Seaton, B.A.
登録日2006-08-07
公開日2006-09-05
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystallographic Analysis of Calcium-dependent Heparin Binding to Annexin A2.
J.Biol.Chem., 281, 2006
2HXG
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Crystal Structure of Mn2+ bound ECAI
分子名称: L-arabinose isomerase, MANGANESE (II) ION
著者Manjasetty, B.A, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC)
登録日2006-08-03
公開日2006-08-15
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structure of Mn2+-bound Escherichia coli L-arabinose Isomerase (ECAI) and Implications in Protein Catalytic Mechanism and Thermo-Stability.
J.Young.Investig., 17, 2007
2FM2
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HCV NS3-4A protease domain complexed with a ketoamide inhibitor, SCH446211
分子名称: BETA-MERCAPTOETHANOL, NS3 protease/helicase, NS4a protein, ...
著者Yi, M, Tong, X, Skelton, A, Chase, R, Chen, T, Prongay, A, Bogen, S.L, Saksena, A.K, Njoroge, F.G, Veselenak, R.L, Pyles, R.B, Bourne, N, Malcolm, B.A, Lemon, S.M.
登録日2006-01-06
公開日2006-02-07
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Mutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor. Reduced RNA replication fitness and partial rescue by second-site mutations
J.Biol.Chem., 281, 2006
2F9B
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Discovery of Novel Heterocyclic Factor VIIa Inhibitors
分子名称: Coagulation factor VII, Tissue factor, {5-(5-AMINO-1H-PYRROLO[3,2-B]PYRIDIN-2-YL)-6-HYDROXY-3'-NITRO-BIPHENYL-3-YL]-ACETIC ACID
著者Rai, R, Kolesnikov, A, Sprengeler, P.A, Torkelson, S, Ton, T, Katz, B.A, Yu, C, Hendrix, J, Shrader, W.D, Stephens, R, Cabuslay, R, Sanford, E, Young, W.B.
登録日2005-12-05
公開日2006-02-28
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.54 Å)
主引用文献Discovery of novel heterocyclic factor VIIa inhibitors.
Bioorg.Med.Chem.Lett., 16, 2006
2HYV
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Human Annexin A2 with heparin hexasaccharide bound
分子名称: 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, Annexin A2, CALCIUM ION
著者Shao, C, Head, J.F, Seaton, B.A.
登録日2006-08-07
公開日2006-09-05
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献Crystallographic analysis of calcium-dependent heparin binding to annexin A2.
J.Biol.Chem., 281, 2006
2GJD
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Distinct functional domains of Ubc9 dictate cell survival and resistance to genotoxic stress
分子名称: Ubiquitin-conjugating enzyme E2-18 kDa
著者van Waardenburg, R.C, Duda, D.M, Lancaster, C.S, Schulman, B.A, Bjornsti, M.A.
登録日2006-03-30
公開日2006-07-04
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Distinct functional domains of ubc9 dictate cell survival and resistance to genotoxic stress.
Mol.Cell.Biol., 26, 2006
2ISO
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Ternary complex of DNA Polymerase beta with a dideoxy terminated primer and 2'-deoxyguanosine 5'-beta, gamma-difluoromethylene triphosphate
分子名称: 2'-DEOXY-5'-O-[({[DIFLUORO(PHOSPHONO)METHYL](HYDROXY)PHOSPHORYL}OXY)(HYDROXY)PHOSPHORYL]GUANOSINE, 5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', ...
著者Sucato, C.A, Upton, T.G, Kashemirov, B.A, Martinek, V, Xiang, Y, Beard, W.A.
登録日2006-10-18
公開日2007-01-30
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Modifying the beta,gamma Leaving-Group Bridging Oxygen Alters Nucleotide Incorporation Efficiency, Fidelity, and the Catalytic Mechanism of DNA Polymerase beta.
Biochemistry, 46, 2007
2FXR
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human beta tryptase II complexed with activated ketone inhibitor CRA-29382
分子名称: ALLYL {(1S)-1-[(5-{4-[(2,3-DIHYDRO-1H-INDEN-2-YLAMINO)CARBONYL]BENZYL}-1,2,4-OXADIAZOL-3-YL)CARBONYL]-3-PYRROLIDIN-3-YLPROPYL}CARBAMATE, Tryptase beta-2
著者Katz, B.A.
登録日2006-02-06
公開日2006-02-09
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure-guided design of Peptide-based tryptase inhibitors.
Biochemistry, 45, 2006
2D7F
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Crystal structure of A lectin from canavalia gladiata seeds complexed with alpha-methyl-mannoside and alpha-aminobutyric acid
分子名称: CALCIUM ION, Concanavalin A, D-ALPHA-AMINOBUTYRIC ACID, ...
著者Delatorre, P, Rocha, B.A.M, Souza, E.P, Freitas, B.T, Moreno, F.B.B.M, Sampaio, A.H, Azevedo Jr, W.F, Cavada, B.S.
登録日2005-11-19
公開日2006-12-19
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Structure of a lectin from Canavalia gladiata seeds: new structural insights for old molecules
Bmc Struct.Biol., 7, 2007

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