2FM2

HCV NS3-4A protease domain complexed with a ketoamide inhibitor, SCH446211

Summary for 2FM2

Entry DOI	10.2210/pdb2fm2/pdb
Related	1A1R 1N1L 1RTL
Descriptor	NS3 protease/helicase, NS4a protein, ZINC ION, ... (6 entities in total)
Functional Keywords	hepatitis c virus, hcv, ns3/4a protease, ketoamide inhibitor, hydrolase
Biological source	Hepatitis C virus More
Total number of polymer chains	4
Total formula weight	48188.37
Authors	Yi, M.,Tong, X.,Skelton, A.,Chase, R.,Chen, T.,Prongay, A.,Bogen, S.L.,Saksena, A.K.,Njoroge, F.G.,Veselenak, R.L.,Pyles, R.B.,Bourne, N.,Malcolm, B.A.,Lemon, S.M. (deposition date: 2006-01-06, release date: 2006-02-07, Last modification date: 2024-04-03)
Primary citation	Yi, M.,Tong, X.,Skelton, A.,Chase, R.,Chen, T.,Prongay, A.,Bogen, S.L.,Saksena, A.K.,Njoroge, F.G.,Veselenak, R.L.,Pyles, R.B.,Bourne, N.,Malcolm, B.A.,Lemon, S.M. Mutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor. Reduced RNA replication fitness and partial rescue by second-site mutations J.Biol.Chem., 281:8205-8215, 2006 Cited by PubMed: 16352601 DOI: 10.1074/jbc.M510246200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation