1YBI
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![BU of 1ybi by Molmil](/molmil-images/mine/1ybi) | Crystal structure of HA33A, a neurotoxin-associated protein from Clostridium botulinum type A | 分子名称: | non-toxin haemagglutinin HA34 | 著者 | Arndt, J.W, Gu, J, Jaroszewski, L, Schwarzenbacher, R, Hanson, M, Lebeda, F.J, Stevens, R.C. | 登録日 | 2004-12-20 | 公開日 | 2005-02-22 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | The Structure of the Neurotoxin-associated Protein HA33/A from Clostridium botulinum Suggests a Reoccurring beta-Trefoil Fold in the Progenitor Toxin Complex. J.Mol.Biol., 346, 2005
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3NMQ
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![BU of 3nmq by Molmil](/molmil-images/mine/3nmq) | Hsp90b N-terminal domain in complex with EC44, a pyrrolo-pyrimidine methoxypyridine inhibitor | 分子名称: | 5-{2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-methylpent-4-yn-2 -ol, Heat shock protein HSP 90-beta | 著者 | Arndt, J.W, Yun, T.J, Harning, E.K, Giza, K, Rabah, D, Li, P, Luchetti, D, Shi, J, Manning, A, Kehry, M.R. | 登録日 | 2010-06-22 | 公開日 | 2010-12-22 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | EC144, a Synthetic Inhibitor of Heat Shock Protein 90, Blocks Innate and Adaptive Immune Responses in Models of Inflammation and Autoimmunity. J.Immunol., 186, 2011
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6PXR
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![BU of 6pxr by Molmil](/molmil-images/mine/6pxr) | Anti-TAU BIIB092 FAB with TAU peptide | 分子名称: | Microtubule-associated protein tau, gosuranemab Fab, heavy chain, ... | 著者 | Arndt, J.W, Quan, C. | 登録日 | 2019-07-26 | 公開日 | 2020-07-29 | 最終更新日 | 2021-02-10 | 実験手法 | X-RAY DIFFRACTION (1.556 Å) | 主引用文献 | Characterization of tau binding by gosuranemab. Neurobiol.Dis., 146, 2020
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1KA4
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![BU of 1ka4 by Molmil](/molmil-images/mine/1ka4) | Structure of Pyrococcus furiosus carboxypeptidase Nat-Pb | 分子名称: | LEAD (II) ION, M32 carboxypeptidase | 著者 | Arndt, J.W, Hao, B, Ramakrishnan, V, Cheng, T, Chan, S.I, Chan, M.K. | 登録日 | 2001-10-31 | 公開日 | 2002-11-06 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Crystal Structure of a Novel Carboxypeptidase from the Hyperthermophilic Archaeon Pyrococcus furiosus Structure, 10, 2002
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1K9X
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![BU of 1k9x by Molmil](/molmil-images/mine/1k9x) | Structure of Pyrococcus furiosus carboxypeptidase Apo-Yb | 分子名称: | M32 carboxypeptidase | 著者 | Arndt, J.W, Hao, B, Ramakrishnan, V, Cheng, T, Chan, S.I, Chan, M.K. | 登録日 | 2001-10-31 | 公開日 | 2002-11-06 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal Structure of a Novel Carboxypeptidase from the Hyperthermophilic Archaeon Pyrococcus furiosus Structure, 10, 2002
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1KA2
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![BU of 1ka2 by Molmil](/molmil-images/mine/1ka2) | Structure of Pyrococcus furiosus Carboxypeptidase Apo-Mg | 分子名称: | M32 carboxypeptidase, MAGNESIUM ION | 著者 | Arndt, J.W, Hao, B, Ramakrishnan, V, Cheng, T, Chan, S.I, Chan, M.K. | 登録日 | 2001-10-31 | 公開日 | 2002-11-06 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal Structure of a Novel Carboxypeptidase from the Hyperthermophilic Archaeon Pyrococcus furiosus Structure, 10, 2002
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3QDD
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1ZB7
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![BU of 1zb7 by Molmil](/molmil-images/mine/1zb7) | Crystal Structure of Botulinum Neurotoxin Type G Light Chain | 分子名称: | CITRATE ANION, ZINC ION, neurotoxin | 著者 | Arndt, J.W, Yu, W, Bi, F, Stevens, R.C. | 登録日 | 2005-04-07 | 公開日 | 2005-07-05 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Crystal structure of botulinum neurotoxin type g light chain: serotype divergence in substrate recognition Biochemistry, 44, 2005
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2FPQ
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![BU of 2fpq by Molmil](/molmil-images/mine/2fpq) | Crystal Structure of Botulinum Neurotoxin Type D Light Chain | 分子名称: | BOTULINUM NEUROTOXIN D LIGHT CHAIN, POTASSIUM ION, ZINC ION | 著者 | Arndt, J.W, Chai, Q, Christian, T, Stevens, R.C. | 登録日 | 2006-01-16 | 公開日 | 2006-03-21 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structure of Botulinum Neurotoxin Type D Light Chain at 1.65 A Resolution: Repercussions for VAMP-2 Substrate Specificity(,). Biochemistry, 45, 2006
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4KY1
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![BU of 4ky1 by Molmil](/molmil-images/mine/4ky1) | humanized HP1/2 Fab | 分子名称: | IMMUNOGLOBULIN IGG1 FAB, HEAVY CHAIN, LIGHT CHAIN | 著者 | Arndt, J.W, Hanf, K.J.M, Lugovskoy, A, Chen, L.L, Jarpe, M, Boriack-Sjodin, A, Li, Y, van Vlijmen, H, Pepinsky, B, Taylor, F, Silvian, L, Taveras, A. | 登録日 | 2013-05-28 | 公開日 | 2013-07-24 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.97 Å) | 主引用文献 | Antibody humanization by redesign of complementarity-determining region residues proximate to the acceptor framework. METHODS (SAN DIEGO), 65, 2014
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3QC4
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![BU of 3qc4 by Molmil](/molmil-images/mine/3qc4) | PDK1 in complex with DFG-OUT inhibitor xxx | 分子名称: | 1-(3,4-difluorobenzyl)-2-oxo-N-{(1R)-2-[(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)oxy]-1-phenylethyl}-1,2-dihydropyridine-3-carboxamide, 3-phosphoinositide-dependent protein kinase 1 | 著者 | Arndt, J.W. | 登録日 | 2011-01-15 | 公開日 | 2011-04-20 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery. Bioorg.Med.Chem.Lett., 21, 2011
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6CT7
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6CR1
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![BU of 6cr1 by Molmil](/molmil-images/mine/6cr1) | adalimumab EFab | 分子名称: | DI(HYDROXYETHYL)ETHER, Heavy chain of adalimumab EFab (VH-IgE CH2), Light chain of adalimumab EFab (VL-IgE CH2), ... | 著者 | Arndt, J.W. | 登録日 | 2018-03-16 | 公開日 | 2018-09-26 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.521 Å) | 主引用文献 | EFab domain substitution as a solution to the light-chain pairing problem of bispecific antibodies. MAbs, 10, 2018
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1HUO
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![BU of 1huo by Molmil](/molmil-images/mine/1huo) | CRYSTAL STRUCTURE OF DNA POLYMERASE BETA COMPLEXED WITH DNA AND CR-TMPPCP | 分子名称: | 5'-D(*AP*AP*TP*AP*GP*GP*CP*GP*TP*CP*G)-3', 5'-D(P*CP*GP*AP*CP*GP*CP*C)-3', CHROMIUM ION, ... | 著者 | Arndt, J.W, Gong, W, Zhong, X, Showalter, A.K, Liu, J, Lin, Z, Paxson, C, Tsai, M.-D, Chan, M.K. | 登録日 | 2001-01-04 | 公開日 | 2001-04-23 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Insight into the catalytic mechanism of DNA polymerase beta: structures of intermediate complexes. Biochemistry, 40, 2001
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1HUZ
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![BU of 1huz by Molmil](/molmil-images/mine/1huz) | CRYSTAL STRUCTURE OF DNA POLYMERASE COMPLEXED WITH DNA AND CR-PCP | 分子名称: | 5'-D(*AP*AP*TP*AP*GP*GP*CP*GP*TP*CP*G)-3', 5'-D(P*CP*GP*AP*CP*GP*CP*CP*T)-3', CHROMIUM ION, ... | 著者 | Arndt, J.W, Gong, W, Zhong, X, Showalter, A.K, Liu, J, Lin, Z, Paxson, C, Tsai, M.-D, Chan, M.K. | 登録日 | 2001-01-04 | 公開日 | 2001-04-23 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Insight into the catalytic mechanism of DNA polymerase beta: structures of intermediate complexes. Biochemistry, 40, 2001
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6CO3
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![BU of 6co3 by Molmil](/molmil-images/mine/6co3) | aducanumab abeta complex | 分子名称: | ALA-GLU-PHE-ARG-HIS-ASP, Fab heavy chain, Fab light chain, ... | 著者 | Arndt, J.W. | 登録日 | 2018-03-10 | 公開日 | 2018-05-02 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.384 Å) | 主引用文献 | Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-beta. Sci Rep, 8, 2018
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6CNR
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![BU of 6cnr by Molmil](/molmil-images/mine/6cnr) | aducanumab apo Fab | 分子名称: | Aducanumab heavy chain, Aducanumab light chain, SULFATE ION | 著者 | Arndt, J.W. | 登録日 | 2018-03-08 | 公開日 | 2018-05-02 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-beta. Sci Rep, 8, 2018
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3HC4
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![BU of 3hc4 by Molmil](/molmil-images/mine/3hc4) | BHA10 IgG1 Fab quadruple mutant variant - antibody directed at human LTBR | 分子名称: | ACETATE ION, IMMUNOGLOBULIN IGG1 FAB, HEAVY CHAIN, ... | 著者 | Arndt, J.W, Jordan, J.L, Lugovskoy, A, Wang, D. | 登録日 | 2009-05-05 | 公開日 | 2009-08-04 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Structural understanding of stabilization patterns in engineered bispecific Ig-like antibody molecules Proteins, 77, 2009
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3HC0
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![BU of 3hc0 by Molmil](/molmil-images/mine/3hc0) | BHA10 IgG1 wild-type Fab - antibody directed at human LTBR | 分子名称: | ACETATE ION, IMMUNOGLOBULIN IGG1 FAB, HEAVY CHAIN, ... | 著者 | Arndt, J.W, Jordan, J.L, Lugovskoy, A, Wang, D. | 登録日 | 2009-05-05 | 公開日 | 2009-08-04 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural understanding of stabilization patterns in engineered bispecific Ig-like antibody molecules Proteins, 77, 2009
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3HC3
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![BU of 3hc3 by Molmil](/molmil-images/mine/3hc3) | BHA10 IgG1 Fab double mutant variant - antibody directed at human LTBR | 分子名称: | ACETATE ION, IMMUNOGLOBULIN IGG1 FAB, HEAVY CHAIN, ... | 著者 | Arndt, J.W, Jordan, J.L, Lugovskoy, A, Wang, D. | 登録日 | 2009-05-05 | 公開日 | 2009-08-04 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Structural understanding of stabilization patterns in engineered bispecific Ig-like antibody molecules Proteins, 77, 2009
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3FZU
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![BU of 3fzu by Molmil](/molmil-images/mine/3fzu) | IgG1 Fab characterized by H/D exchange | 分子名称: | immunoglobulin IgG1 Fab, heavy chain, light chain | 著者 | Arndt, J, Houde, D, Domeier, W, Berkowitz, S, Engen, J.R. | 登録日 | 2009-01-26 | 公開日 | 2009-03-17 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Characterization of IgG1 conformation and conformational dynamics by hydrogen/deuterium exchange mass spectrometry. Anal Chem, 81, 2009
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4OQT
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![BU of 4oqt by Molmil](/molmil-images/mine/4oqt) | LINGO-1/Li81 Fab complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy Chain of Li81 Fab, ... | 著者 | Pepinsky, R.B, Arndt, J.W, Quan, C, Gao, Y, Quintero-Monzon, O, Lee, X, Mi, S. | 登録日 | 2014-02-10 | 公開日 | 2014-05-14 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.23 Å) | 主引用文献 | Structure of the LINGO-1-Anti-LINGO-1 Li81 Antibody Complex Provides Insights into the Biology of LINGO-1 and the Mechanism of Action of the Antibody Therapy. J.Pharmacol.Exp.Ther., 350, 2014
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6N29
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![BU of 6n29 by Molmil](/molmil-images/mine/6n29) | Crystal structure of monomeric von Willebrand Factor D`D3 assembly | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Dong, X, Arndt, J.W, Springer, T.A. | 登録日 | 2018-11-12 | 公開日 | 2019-01-23 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The von Willebrand factor D'D3 assembly and structural principles for factor VIII binding and concatemer biogenesis. Blood, 133, 2019
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7TLH
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7TL6
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![BU of 7tl6 by Molmil](/molmil-images/mine/7tl6) | Murine meteorin N-terminal CUB domain | 分子名称: | Meteorin, SULFATE ION | 著者 | Quan, C, Arndt, J.W, Pepinsky, B, Gong, B.J, Dolnikova, J. | 登録日 | 2022-01-18 | 公開日 | 2023-01-25 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Identification and structure determination of stable domains of meteorin and meteorin-like To Be Published
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