3QDD
HSP90A N-terminal domain in complex with BIIB021
Summary for 3QDD
Entry DOI | 10.2210/pdb3qdd/pdb |
Descriptor | Heat shock protein HSP 90-alpha, 6-chloro-9-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-9H-purin-2-amine (3 entities in total) |
Functional Keywords | atpase, chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P07900 |
Total number of polymer chains | 1 |
Total formula weight | 27058.68 |
Authors | Arndt, J.W.,Biamonte, M.A. (deposition date: 2011-01-18, release date: 2012-07-18, Last modification date: 2024-05-22) |
Primary citation | Shi, J.,Van de Water, R.,Hong, K.,Lamer, R.B.,Weichert, K.W.,Sandoval, C.M.,Kasibhatla, S.R.,Boehm, M.F.,Chao, J.,Lundgren, K.,Timple, N.,Lough, R.,Ibanez, G.,Boykin, C.,Burrows, F.J.,Kehry, M.R.,Yun, T.J.,Harning, E.K.,Ambrose, C.,Thompson, J.,Bixler, S.A.,Dunah, A.,Snodgrass-Belt, P.,Arndt, J.,Enyedy, I.J.,Li, P.,Hong, V.S.,McKenzie, A.,Biamonte, M.A. EC144 Is a Potent Inhibitor of the Heat Shock Protein 90. J.Med.Chem., 55:7786-7795, 2012 Cited by PubMed: 22938030DOI: 10.1021/jm300810x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.79 Å) |
Structure validation
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