4M9Z
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![BU of 4m9z by Molmil](/molmil-images/mine/4m9z) | Crystal structure of CED-4 bound CED-3 fragment | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CED-3 fragment, Cell death protein 4, ... | 著者 | Huang, W.J, Jinag, T.Y, Choi, W.Y, Wang, J.W, Shi, Y.G. | 登録日 | 2013-08-15 | 公開日 | 2013-10-23 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (3.405 Å) | 主引用文献 | Mechanistic insights into CED-4-mediated activation of CED-3. Genes Dev., 27, 2013
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5XHC
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![BU of 5xhc by Molmil](/molmil-images/mine/5xhc) | Crystal structure of T2R-TTL-PO10 complex | 分子名称: | (3Z,6Z)-3-[(4-tert-butyl-1H-imidazol-5-yl)methylidene]-6-[[3-(4-fluorophenyl)carbonylphenyl]methylidene]piperazine-2,5-dione, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Chu, Y, Wang, Y, Yang, J, Li, W. | 登録日 | 2017-04-20 | 公開日 | 2017-10-18 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Synthesis, biological evaluation and X-ray structure of anti-microtubule agents To Be Published
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5XIW
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![BU of 5xiw by Molmil](/molmil-images/mine/5xiw) | Crystal structure of T2R-TTL-Colchicine complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ... | 著者 | Wang, Y, Yang, J, Wang, T, Chen, L. | 登録日 | 2017-04-27 | 公開日 | 2018-04-18 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin. J. Biol. Chem., 2018
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3HI6
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![BU of 3hi6 by Molmil](/molmil-images/mine/3hi6) | |
3RLR
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![BU of 3rlr by Molmil](/molmil-images/mine/3rlr) | Co-crystal structure of the HSP90 ATP binding domain in complex with 4-(2,4-dichloro-5-methoxyphenyl)-2,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | 分子名称: | 4-(2,4-dichloro-5-methoxyphenyl)-2,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, Heat shock protein HSP 90-alpha, PHOSPHATE ION | 著者 | Kung, P.-P, Sinnema, P.-J, Richardson, P, Hickey, M.J, Gajiwala, K.S, Wang, F, Huang, B, McClellan, G, Wang, J, Maegley, K, Bergqvist, S, Mehta, P.P, Kania, R. | 登録日 | 2011-04-20 | 公開日 | 2011-06-08 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Design strategies to target crystallographic waters applied to the Hsp90 molecular chaperone. Bioorg.Med.Chem.Lett., 21, 2011
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3F78
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![BU of 3f78 by Molmil](/molmil-images/mine/3f78) | Crystal structure of wild type LFA1 I domain complexed with isoflurane | 分子名称: | 1-CHLORO-2,2,2-TRIFLUOROETHYL DIFLUOROMETHYL ETHER, GLYCEROL, Integrin alpha-L, ... | 著者 | Zhang, H, Wang, J.-H. | 登録日 | 2008-11-07 | 公開日 | 2009-06-23 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystal structure of isoflurane bound to integrin LFA-1 supports a unified mechanism of volatile anesthetic action in the immune and central nervous systems. Faseb J., 23, 2009
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4M9S
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![BU of 4m9s by Molmil](/molmil-images/mine/4m9s) | crystal structure of CED-4 bound CED-3 fragment | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CED-3 fragment, Cell death protein 4, ... | 著者 | Huang, W.J, Jinag, T.Y, Choi, W.Y, Wang, J.W, Shi, Y.G. | 登録日 | 2013-08-15 | 公開日 | 2013-10-23 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (3.207 Å) | 主引用文献 | Mechanistic insights into CED-4-mediated activation of CED-3. Genes Dev., 27, 2013
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2Q06
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![BU of 2q06 by Molmil](/molmil-images/mine/2q06) | Crystal structure of Influenza A Virus H5N1 Nucleoprotein | 分子名称: | Nucleoprotein | 著者 | Ng, A.K.L, Zhang, H, Tan, K, Wang, J, Shaw, P.C. | 登録日 | 2007-05-21 | 公開日 | 2008-05-27 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design. Faseb J., 22, 2008
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3TIC
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![BU of 3tic by Molmil](/molmil-images/mine/3tic) | Crystal structure of 1957 pandemic H2N2 neuraminidase complexed with zanamivir | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Vavricka, C.J, Li, Q, Wu, Y, Qi, J, Wang, M, Liu, Y, Gao, F, Liu, J, Feng, E, He, J, Wang, J, Liu, H, Jiang, H, Gao, G.F. | 登録日 | 2011-08-20 | 公開日 | 2011-11-16 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition Plos Pathog., 7, 2011
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3TIA
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![BU of 3tia by Molmil](/molmil-images/mine/3tia) | Crystal structure of 1957 pandemic H2N2 neuraminidase complexed with laninamivir | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-acetamido-2,6-anhydro-4-carbamimidamido-3,4,5-trideoxy-7-O-methyl-D-glycero-D-galacto-non-2-enonic acid, ... | 著者 | Vavricka, C.J, Li, Q, Wu, Y, Qi, J, Wang, M, Liu, Y, Gao, F, Liu, J, Feng, E, He, J, Wang, J, Liu, H, Jiang, H, Gao, G.F. | 登録日 | 2011-08-20 | 公開日 | 2011-11-16 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition Plos Pathog., 7, 2011
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7YUL
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![BU of 7yul by Molmil](/molmil-images/mine/7yul) | Crystal structure of human BEND6 BEN domain in complex with DNA | 分子名称: | BEN domain-containing protein 6, DNA (5'-D(*CP*TP*CP*TP*CP*GP*CP*GP*AP*GP*AP*G)-3'), GLYCOLIC ACID | 著者 | Liu, K, Xiao, Y.Q, Zhang, J, Min, J.R. | 登録日 | 2022-08-17 | 公開日 | 2023-04-26 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Structural insights into DNA recognition by the BEN domain of the transcription factor BANP. J.Biol.Chem., 299, 2023
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3NQZ
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![BU of 3nqz by Molmil](/molmil-images/mine/3nqz) | Crystal structure of the autoprocessed Vibriolysin MCP-02 with E369A mutation | 分子名称: | CALCIUM ION, Secreted metalloprotease Mcp02, ZINC ION | 著者 | Gao, X, Wang, J, Chen, L, Wu, J.-W, Zhang, Y.-Z. | 登録日 | 2010-06-30 | 公開日 | 2010-10-06 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structural basis for the autoprocessing of zinc metalloproteases in the thermolysin family Proc.Natl.Acad.Sci.USA, 107, 2010
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6IFL
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![BU of 6ifl by Molmil](/molmil-images/mine/6ifl) | Cryo-EM structure of type III-A Csm-NTR complex | 分子名称: | NTR, Type III-A CRISPR-associated RAMP protein Csm3, Type III-A CRISPR-associated RAMP protein Csm4, ... | 著者 | You, L, Ma, J, Wang, J, Zhang, X, Wang, Y. | 登録日 | 2018-09-20 | 公開日 | 2018-12-12 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | 主引用文献 | Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference Cell, 176, 2019
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7YUN
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![BU of 7yun by Molmil](/molmil-images/mine/7yun) | Crystal structure of human BEND6 BEN domain in complex with methylated DNA | 分子名称: | BEN domain-containing protein 6, DNA (5'-D(*CP*TP*CP*TP*CP*GP*(5CM)P*GP*AP*GP*AP*G)-3') | 著者 | Liu, K, Xiao, Y.Q, Zhang, J, Min, J.R. | 登録日 | 2022-08-17 | 公開日 | 2023-05-03 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | 主引用文献 | Structural insights into DNA recognition by the BEN domain of the transcription factor BANP. J.Biol.Chem., 299, 2023
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4EAK
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![BU of 4eak by Molmil](/molmil-images/mine/4eak) | Co-crystal structure of an AMPK core with ATP | 分子名称: | 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... | 著者 | Chen, L, Wang, J, Zhang, Y.-Y, Yan, S.F, Neumann, D, Schlattner, U, Wang, Z.-X, Wu, J.-W. | 登録日 | 2012-03-22 | 公開日 | 2012-06-06 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | AMP-activated protein kinase undergoes nucleotide-dependent conformational changes Nat.Struct.Mol.Biol., 19, 2012
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6IFY
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![BU of 6ify by Molmil](/molmil-images/mine/6ify) | Type III-A Csm complex, Cryo-EM structure of Csm-CTR1 | 分子名称: | CTR1, Type III-A CRISPR-associated RAMP protein Csm3, Type III-A CRISPR-associated RAMP protein Csm4, ... | 著者 | You, L, Ma, J, Wang, J, Zhang, X, Wang, Y. | 登録日 | 2018-09-21 | 公開日 | 2018-12-12 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference Cell, 176, 2019
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7VQD
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![BU of 7vqd by Molmil](/molmil-images/mine/7vqd) | Structure of MA1831 from Methanosarcina acetivorans in complex with farnesyl pyrophosphate and geranylgeranyl pyrophosphate. | 分子名称: | Di-trans-poly-cis-decaprenylcistransferase, FARNESYL DIPHOSPHATE, NerylNeryl pyrophosphate, ... | 著者 | Zhang, L.L, Chen, C.C, Liu, W.D, Huang, J.W, Zhang, X.W, Liu, B.B, Guo, R.T. | 登録日 | 2021-10-19 | 公開日 | 2022-08-31 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Structural insights to a bi-functional isoprenyl diphosphate synthase that can catalyze head-to-tail and head-to-middle condensation. Int.J.Biol.Macromol., 214, 2022
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7VQC
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![BU of 7vqc by Molmil](/molmil-images/mine/7vqc) | Structure of MA1831 from Methanosarcina acetivorans in complex with pyrophosphate | 分子名称: | Di-trans-poly-cis-decaprenylcistransferase, PYROPHOSPHATE 2-, SULFATE ION | 著者 | Zhang, L.L, Chen, C.C, Liu, W.D, Huang, J.W, Zhang, X.W, Liu, B.B, Guo, R.T. | 登録日 | 2021-10-19 | 公開日 | 2022-08-31 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Structural insights to a bi-functional isoprenyl diphosphate synthase that can catalyze head-to-tail and head-to-middle condensation. Int.J.Biol.Macromol., 214, 2022
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7VQB
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![BU of 7vqb by Molmil](/molmil-images/mine/7vqb) | Structure of MA1831 from Methanosarcina acetivorans in complex with farnesyl pyrophosphate and dimethylallyl diphosphate | 分子名称: | DIMETHYLALLYL DIPHOSPHATE, Di-trans-poly-cis-decaprenylcistransferase, FARNESYL DIPHOSPHATE, ... | 著者 | Zhang, L.L, Chen, C.C, Liu, W.D, Huang, J.W, Zhang, X.W, Liu, B.B, Guo, R.T. | 登録日 | 2021-10-19 | 公開日 | 2022-08-31 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | Structural insights to a bi-functional isoprenyl diphosphate synthase that can catalyze head-to-tail and head-to-middle condensation. Int.J.Biol.Macromol., 214, 2022
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7VQA
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![BU of 7vqa by Molmil](/molmil-images/mine/7vqa) | Structure of MA1831 from Methanosarcina acetivorans in complex with dimethylallyl diphosphate. | 分子名称: | DIMETHYLALLYL DIPHOSPHATE, Di-trans-poly-cis-decaprenylcistransferase, MAGNESIUM ION, ... | 著者 | Zhang, L.L, Chen, C.C, Liu, W.D, Huang, J.W, Zhang, X.W, Liu, B.B, Guo, R.T. | 登録日 | 2021-10-19 | 公開日 | 2022-08-31 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Structural insights to a bi-functional isoprenyl diphosphate synthase that can catalyze head-to-tail and head-to-middle condensation. Int.J.Biol.Macromol., 214, 2022
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7VQ9
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![BU of 7vq9 by Molmil](/molmil-images/mine/7vq9) | Structure of MA1831 from Methanosarcina acetivorans in complex with farnesyl thiopyrophosphate and isopentyl S-thiolodiphosphate | 分子名称: | 3-methylbut-3-enylsulfanyl(phosphonooxy)phosphinic acid, Di-trans-poly-cis-decaprenylcistransferase, MAGNESIUM ION, ... | 著者 | Zhang, L.L, Chen, C.C, Liu, W.D, Huang, J.W, Zhang, X.W, Liu, B.B, Guo, R.T. | 登録日 | 2021-10-19 | 公開日 | 2022-08-31 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Structural insights to a bi-functional isoprenyl diphosphate synthase that can catalyze head-to-tail and head-to-middle condensation. Int.J.Biol.Macromol., 214, 2022
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2LRW
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![BU of 2lrw by Molmil](/molmil-images/mine/2lrw) | Solution structure of a ubiquitin-like protein from Trypanosoma brucei | 分子名称: | Ubiquitin, putative | 著者 | Wang, R, Wang, T, Liao, S, Zhang, J, Tu, X. | 登録日 | 2012-04-13 | 公開日 | 2013-04-24 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of a ubiqutin-like protein from Trypanosoma bucei To be Published
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4EAL
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![BU of 4eal by Molmil](/molmil-images/mine/4eal) | Co-crystal of AMPK core with ATP soaked with AMP | 分子名称: | 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... | 著者 | Chen, L, Wang, J, Zhang, Y.-Y, Yan, S.F, Neumann, D, Schlattner, U, Wang, Z.-X, Wu, J.-W. | 登録日 | 2012-03-22 | 公開日 | 2012-06-06 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.506 Å) | 主引用文献 | AMP-activated protein kinase undergoes nucleotide-dependent conformational changes Nat.Struct.Mol.Biol., 19, 2012
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3NQY
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![BU of 3nqy by Molmil](/molmil-images/mine/3nqy) | Crystal structure of the autoprocessed complex of Vibriolysin MCP-02 with a single point mutation E346A | 分子名称: | CALCIUM ION, Secreted metalloprotease Mcp02, ZINC ION | 著者 | Gao, X, Wang, J, Wu, J.-W, Zhang, Y.-Z. | 登録日 | 2010-06-30 | 公開日 | 2010-10-06 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural basis for the autoprocessing of zinc metalloproteases in the thermolysin family Proc.Natl.Acad.Sci.USA, 107, 2010
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3F4M
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![BU of 3f4m by Molmil](/molmil-images/mine/3f4m) | Crystal structure of TIPE2 | 分子名称: | CHLORIDE ION, Tumor necrosis factor, alpha-induced protein 8-like protein 2 | 著者 | Zhang, X, Wang, J, Shi, Y. | 登録日 | 2008-11-01 | 公開日 | 2009-03-17 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.696 Å) | 主引用文献 | Crystal structure of TIPE2 provides insights into immune homeostasis Nat.Struct.Mol.Biol., 16, 2009
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