3RLR
Co-crystal structure of the HSP90 ATP binding domain in complex with 4-(2,4-dichloro-5-methoxyphenyl)-2,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
Summary for 3RLR
Entry DOI | 10.2210/pdb3rlr/pdb |
Related | 3RLP 3RLQ |
Descriptor | Heat shock protein HSP 90-alpha, 4-(2,4-dichloro-5-methoxyphenyl)-2,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | chaperone |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P07900 |
Total number of polymer chains | 2 |
Total formula weight | 51955.07 |
Authors | Kung, P.-P.,Sinnema, P.-J.,Richardson, P.,Hickey, M.J.,Gajiwala, K.S.,Wang, F.,Huang, B.,McClellan, G.,Wang, J.,Maegley, K.,Bergqvist, S.,Mehta, P.P.,Kania, R. (deposition date: 2011-04-20, release date: 2011-06-08, Last modification date: 2024-02-28) |
Primary citation | Kung, P.P.,Sinnema, P.J.,Richardson, P.,Hickey, M.J.,Gajiwala, K.S.,Wang, F.,Huang, B.,McClellan, G.,Wang, J.,Maegley, K.,Bergqvist, S.,Mehta, P.P.,Kania, R. Design strategies to target crystallographic waters applied to the Hsp90 molecular chaperone. Bioorg.Med.Chem.Lett., 21:3557-3562, 2011 Cited by PubMed: 21612924DOI: 10.1016/j.bmcl.2011.04.130 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)