3RLQ

Co-crystal structure of the HSP90 ATP binding domain in complex with 4-(2,4-dichloro-5-methoxyphenyl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5- carbonitrile

Summary for 3RLQ

Entry DOI	10.2210/pdb3rlq/pdb
Related	3RLP 3RLR
Descriptor	Heat shock protein HSP 90-alpha, 4-(2,4-dichloro-5-methoxyphenyl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, PHOSPHATE ION, ... (4 entities in total)
Functional Keywords	chaperone
Biological source	Homo sapiens (human)
Cellular location	Nucleus : P07900
Total number of polymer chains	2
Total formula weight	51927.01
Authors	Kung, P.-P.,Sinnema, P.-J.,Richardson, P.,Hickey, M.J.,Gajiwala, K.S.,Wang, F.,Huang, B.,McClellan, G.,Wang, J.,Maegley, K.,Bergqvist, S.,Mehta, P.P.,Kania, R. (deposition date: 2011-04-20, release date: 2011-06-08, Last modification date: 2024-02-28)
Primary citation	Kung, P.P.,Sinnema, P.J.,Richardson, P.,Hickey, M.J.,Gajiwala, K.S.,Wang, F.,Huang, B.,McClellan, G.,Wang, J.,Maegley, K.,Bergqvist, S.,Mehta, P.P.,Kania, R. Design strategies to target crystallographic waters applied to the Hsp90 molecular chaperone. Bioorg.Med.Chem.Lett., 21:3557-3562, 2011 Cited by PubMed: 21612924 DOI: 10.1016/j.bmcl.2011.04.130 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation