1AWJ
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![BU of 1awj by Molmil](/molmil-images/mine/1awj) | INTRAMOLECULAR ITK-PROLINE COMPLEX, NMR, MINIMIZED AVERAGE STRUCTURE | Descriptor: | ITK | Authors: | Andreotti, A.H, Bunnell, S.C, Feng, S, Berg, L.J, Schreiber, S.L. | Deposit date: | 1997-10-02 | Release date: | 1998-01-14 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Regulatory intramolecular association in a tyrosine kinase of the Tec family. Nature, 385, 1997
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2K79
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2K7A
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![BU of 2k7a by Molmil](/molmil-images/mine/2k7a) | |
8S9F
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8S93
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![BU of 8s93 by Molmil](/molmil-images/mine/8s93) | Crystal structure of the PH-TH/kinase complex of Bruton's tyrosine kinase | Descriptor: | 2-[3'-(hydroxymethyl)-1-methyl-5-({5-[(2S)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-6-oxo[1,6-dihydro[3,4'-bipyridine]]-2'-yl]-7,7-dimethyl-3,4,7,8-tetrahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one, GLYCEROL, Tyrosine-protein kinase BTK, ... | Authors: | Lin, D.Y, Andreotti, A.H. | Deposit date: | 2023-03-27 | Release date: | 2023-08-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. Elife, 12, 2024
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2ETZ
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![BU of 2etz by Molmil](/molmil-images/mine/2etz) | The NMR minimized average structure of the Itk SH2 domain bound to a phosphopeptide | Descriptor: | Lymphocyte cytosolic protein 2 phosphopeptide fragment, Tyrosine-protein kinase ITK/TSK | Authors: | Sundd, M, Pletneva, E.V, Fulton, D.B, Andreotti, A.H. | Deposit date: | 2005-10-27 | Release date: | 2006-02-07 | Last modified: | 2022-03-09 | Method: | SOLUTION NMR | Cite: | Molecular Details of Itk Activation by Prolyl Isomerization and Phospholigand Binding: The NMR Structure of the Itk SH2 Domain Bound to a Phosphopeptide. J.Mol.Biol., 357, 2006
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2EU0
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![BU of 2eu0 by Molmil](/molmil-images/mine/2eu0) | The NMR ensemble structure of the Itk SH2 domain bound to a phosphopeptide | Descriptor: | Lymphocyte cytosolic protein 2 phosphopeptide fragment, Tyrosine-protein kinase ITK/TSK | Authors: | Sundd, M, Pletneva, E.V, Fulton, D.B, Andreotti, A.H. | Deposit date: | 2005-10-27 | Release date: | 2006-02-07 | Last modified: | 2022-03-09 | Method: | SOLUTION NMR | Cite: | Molecular Details of Itk Activation by Prolyl Isomerization and Phospholigand Binding: The NMR Structure of the Itk SH2 Domain Bound to a Phosphopeptide. J.Mol.Biol., 357, 2006
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8GMB
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![BU of 8gmb by Molmil](/molmil-images/mine/8gmb) | Crystal structure of the full-length Bruton's tyrosine kinase (PH-TH domain not visible) | Descriptor: | 2-[3'-(hydroxymethyl)-1-methyl-5-({5-[(2S)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-6-oxo[1,6-dihydro[3,4'-bipyridine]]-2'-yl]-7,7-dimethyl-3,4,7,8-tetrahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one, Tyrosine-protein kinase BTK | Authors: | Lin, D.Y, Andreotti, A.H. | Deposit date: | 2023-03-24 | Release date: | 2023-08-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. Elife, 12, 2024
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8FF0
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8FD9
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3S9K
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![BU of 3s9k by Molmil](/molmil-images/mine/3s9k) | Crystal structure of the Itk SH2 domain. | Descriptor: | CITRIC ACID, Tyrosine-protein kinase ITK/TSK | Authors: | Joseph, R.E, Ginder, N.D, Hoy, J.A, Nix, J.C, Fulton, B.D, Honzatko, R.B, Andreotti, A.H. | Deposit date: | 2011-06-01 | Release date: | 2012-02-08 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.354 Å) | Cite: | Structure of the interleukin-2 tyrosine kinase Src homology 2 domain; comparison between X-ray and NMR-derived structures. Acta Crystallogr.,Sect.F, 68, 2012
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2LMJ
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![BU of 2lmj by Molmil](/molmil-images/mine/2lmj) | Itk-sh3 | Descriptor: | Tyrosine-protein kinase ITK/TSK | Authors: | Kristiansen, P, Bie Andersen, T, Huszenicza, Z, Andreotti, A.H, Spurkland, A. | Deposit date: | 2011-12-05 | Release date: | 2012-12-05 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | The SH3 domains of the Tec family kinase Itk and the Src family kinase Lck compete for adjacent sites on T-cell specific adapter protein To be Published
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1YX7
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![BU of 1yx7 by Molmil](/molmil-images/mine/1yx7) | NMR structure of Calsensin, energy minimized average structure. | Descriptor: | Calsensin | Authors: | Venkitaramani, D.V, Fulton, D.B, Andreotti, A.H, Johansen, K.M, Johansen, J. | Deposit date: | 2005-02-19 | Release date: | 2005-04-01 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure and backbone dynamics of Calsensin, an invertebrate neuronal calcium-binding protein. Protein Sci., 14, 2005
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1YX8
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![BU of 1yx8 by Molmil](/molmil-images/mine/1yx8) | NMR structure of Calsensin, 20 low energy structures. | Descriptor: | Calsensin | Authors: | Venkitaramani, D.V, Fulton, D.B, Andreotti, A.H, Johansen, K.M, Johansen, J. | Deposit date: | 2005-02-19 | Release date: | 2005-04-05 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure and backbone dynamics of Calsensin, an invertebrate neuronal calcium-binding protein. Protein Sci., 14, 2005
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1LUK
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![BU of 1luk by Molmil](/molmil-images/mine/1luk) | NMR Structure of the Itk SH2 domain, Pro287cis, Energy minimized average structure | Descriptor: | Tyrosine-protein kinase ITK/TSK | Authors: | Mallis, R.J, Brazin, K.N, Fulton, B.F, Andreotti, A.H. | Deposit date: | 2002-05-22 | Release date: | 2002-11-27 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Structural characterization of a proline-driven conformational switch
within the Itk SH2 domain Nat.Struct.Biol., 9, 2002
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1LUN
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![BU of 1lun by Molmil](/molmil-images/mine/1lun) | NMR Structure of the Itk SH2 domain, Pro287trans, energy minimized average structure | Descriptor: | Tyrosine-protein kinase ITK/TSK | Authors: | Mallis, R.J, Brazin, K.N, Fulton, D.B, Andreotti, A.H. | Deposit date: | 2002-05-22 | Release date: | 2002-11-27 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Structural characterization of a proline-driven conformational switch
within the Itk SH2 domain Nat.Struct.Biol., 9, 2002
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1MA4
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![BU of 1ma4 by Molmil](/molmil-images/mine/1ma4) | |
1MA6
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1LUM
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![BU of 1lum by Molmil](/molmil-images/mine/1lum) | NMR Structure of the Itk SH2 domain, Pro287trans, 20 low energy structures | Descriptor: | Tyrosine-protein kinase ITK/TSK | Authors: | Mallis, R.J, Brazin, K.N, Fulton, D.B, Andreotti, A.H. | Deposit date: | 2002-05-22 | Release date: | 2002-11-27 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Structural characterization of a proline-driven conformational switch
within the Itk SH2 domain Nat.Struct.Biol., 9, 2002
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1MA5
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1MA2
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