8FF0

Structure of BTK kinase domain with the second-generation inhibitor tirabrutinib

Summary for 8FF0

Entry DOI	10.2210/pdb8ff0/pdb
Related	8FD9
Descriptor	Tyrosine-protein kinase BTK, 6-azanyl-9-[(3~{R})-1-[(~{E})-but-2-enoyl]pyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one (3 entities in total)
Functional Keywords	inhibitor, kinase, complex, covalent, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Mus musculus (house mouse)
Total number of polymer chains	1
Total formula weight	32278.02
Authors	Lin, D.Y.,Andreotti, A.H. (deposition date: 2022-12-07, release date: 2023-07-05, Last modification date: 2023-09-13)
Primary citation	Lin, D.Y.,Andreotti, A.H. Structure of BTK kinase domain with the second-generation inhibitors acalabrutinib and tirabrutinib. Plos One, 18:e0290872-e0290872, 2023 Cited by PubMed: 37651403 DOI: 10.1371/journal.pone.0290872 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation