8FD9
Structure of BTK kinase domain with the second-generation inhibitor acalabrutinib
Summary for 8FD9
Entry DOI | 10.2210/pdb8fd9/pdb |
Descriptor | Tyrosine-protein kinase BTK, 4-[(4S)-8-amino-3-{(2S)-1-[(2E)-but-2-enoyl]pyrrolidin-2-yl}imidazo[1,5-a]pyrazin-1-yl]-N-(pyridin-2-yl)benzamide, BROMIDE ION, ... (4 entities in total) |
Functional Keywords | inhibitor, kinase, complex, covalent, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Mus musculus (house mouse) |
Total number of polymer chains | 1 |
Total formula weight | 32608.66 |
Authors | Lin, D.Y.,Andreotti, A.H. (deposition date: 2022-12-02, release date: 2023-07-05, Last modification date: 2023-09-13) |
Primary citation | Lin, D.Y.,Andreotti, A.H. Structure of BTK kinase domain with the second-generation inhibitors acalabrutinib and tirabrutinib. Plos One, 18:e0290872-e0290872, 2023 Cited by PubMed: 37651403DOI: 10.1371/journal.pone.0290872 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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