8FD9
Structure of BTK kinase domain with the second-generation inhibitor acalabrutinib
Functional Information from GO Data
Functional Information from PROSITE/UniProt
site_id | PS00109 |
Number of Residues | 13 |
Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FLHrDLAARNCLV |
Chain | Residue | Details |
A | PHE517-VAL529 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 |
Chain | Residue | Details |
A | ASP521 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
Chain | Residue | Details |
A | LEU408 | |
A | ARG430 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | MOD_RES: Phosphotyrosine; by LYN and SYK => ECO:0000269|PubMed:8629002, ECO:0007744|PubMed:17947660 |
Chain | Residue | Details |
A | TYR551 |
site_id | SWS_FT_FI4 |
Number of Residues | 3 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q06187 |
Chain | Residue | Details |
A | SER604 | |
A | SER623 | |
A | SER659 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q06187 |
Chain | Residue | Details |
A | PRO617 |