3U3N
 
 | | Crystal structure of tablysin-15 | | Descriptor: | CITRIC ACID, PALMITIC ACID, PRASEODYMIUM ION, ... | | Authors: | Andersen, J.F. | | Deposit date: | 2011-10-06 | | Release date: | 2012-02-15 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.651 Å) | | Cite: | Structure of protein having inhibitory disintegrin and leukotriene scavenging functions contained in single domain.
J.Biol.Chem., 287, 2012
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8UIN
 | | Structure of the C3bBb-albicin complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Albicin, ... | | Authors: | Andersen, J.F, Lei, H. | | Deposit date: | 2023-10-10 | | Release date: | 2024-05-08 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (3.86 Å) | | Cite: | Mechanism of complement inhibition by a mosquito protein revealed through cryo-EM.
Commun Biol, 7, 2024
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8UH2
 | | Complex of C3b with the inhibitor albicin | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Albicin, Complement C3 beta chain, ... | | Authors: | Andersen, J.F, Lei, H, Strayer, E, Ribeiro, J.M. | | Deposit date: | 2023-10-06 | | Release date: | 2024-05-08 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (3.59 Å) | | Cite: | Mechanism of complement inhibition by a mosquito protein revealed through cryo-EM.
Commun Biol, 7, 2024
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2QEO
 | | Crystal Structure of Anopheles gambiae D7R4-norepinephrine complex | | Descriptor: | D7R4 Protein, L-NOREPINEPHRINE | | Authors: | Andersen, J.F, Mans, B.J, Calvo, E, Ribeiro, J.M. | | Deposit date: | 2007-06-26 | | Release date: | 2007-10-09 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.315 Å) | | Cite: | The Crystal Structure of D7r4, a Salivary Biogenic Amine-binding Protein from the Malaria Mosquito Anopheles gambiae
J.Biol.Chem., 282, 2007
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2QEV
 | | Crystal Structure of Anopheles gambiae D7r4 | | Descriptor: | D7R4 Protein | | Authors: | Andersen, J.F, Mans, B.J, Calvo, E, Ribeiro, J.M. | | Deposit date: | 2007-06-26 | | Release date: | 2007-10-09 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.998 Å) | | Cite: | The Crystal Structure of D7r4, a Salivary Biogenic Amine-binding Protein from the Malaria Mosquito Anopheles gambiae
J.Biol.Chem., 282, 2007
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2QEB
 | | Crystal Structure of Anopheles Gambiae D7R4-Histamine Complex | | Descriptor: | D7R4 Protein, GLYCEROL, HISTAMINE | | Authors: | Andersen, J.F, Mans, B.J, Calvo, E, Ribeiro, J.M. | | Deposit date: | 2007-06-25 | | Release date: | 2007-10-09 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.003 Å) | | Cite: | The Crystal Structure of D7r4, a Salivary Biogenic Amine-binding Protein from the Malaria Mosquito Anopheles gambiae
J.Biol.Chem., 282, 2007
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5V13
 | | Mosquito juvenile hormone-binding protein | | Descriptor: | AAEL008620-PA odorant-binding protein, methyl (2E,6E)-9-[(2R)-3,3-dimethyloxiran-2-yl]-3,7-dimethylnona-2,6-dienoate | | Authors: | Andersen, J.F, Kim, I.H. | | Deposit date: | 2017-03-01 | | Release date: | 2017-08-09 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | A mosquito hemolymph odorant-binding protein family member specifically binds juvenile hormone.
J. Biol. Chem., 292, 2017
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8EOK
 | | Structure of the C3bB proconvertase in complex with lufaxin and factor Xa | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Activated factor Xa heavy chain, Complement C3 beta chain, ... | | Authors: | Andersen, J.F, Lei, H. | | Deposit date: | 2022-10-03 | | Release date: | 2023-08-30 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.53 Å) | | Cite: | A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism.
Blood, 141, 2023
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8ENU
 | | Structure of the C3bB proconvertase in complex with lufaxin | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3 beta chain, Complement C3b alpha' chain, ... | | Authors: | Andersen, J.F, Lei, H. | | Deposit date: | 2022-09-30 | | Release date: | 2023-08-09 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.22 Å) | | Cite: | A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism.
Blood, 141, 2023
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8EO2
 | | Lufaxin a bifunctional inhibitor of complement and coagulation | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BROMIDE ION, ... | | Authors: | Andersen, J.F, Strayer, E.C. | | Deposit date: | 2022-10-01 | | Release date: | 2023-08-09 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism.
Blood, 141, 2023
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4JD9
 | | Contact pathway inhibitor from a sand fly | | Descriptor: | 14.5 kDa salivary protein, SULFATE ION | | Authors: | Andersen, J.F, Xu, X, Alvarenga, P. | | Deposit date: | 2013-02-24 | | Release date: | 2013-10-16 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (2.601 Å) | | Cite: | Novel family of insect salivary inhibitors blocks contact pathway activation by binding to polyphosphate, heparin, and dextran sulfate.
Arterioscler Thromb Vasc Biol, 33, 2013
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6MT7
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6MTF
 | | D7 protein from Phlebotomus duboscqi, native | | Descriptor: | 26.7 kDa salivary protein, FRAGMENT OF TRITON X-100 | | Authors: | Andersen, J.F, Jablonka, W. | | Deposit date: | 2018-10-19 | | Release date: | 2019-04-10 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.92 Å) | | Cite: | Functional and structural similarities of D7 proteins in the independently-evolved salivary secretions of sand flies and mosquitoes.
Sci Rep, 9, 2019
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3Q6T
 | | Salivary protein from Lutzomyia longipalpis, Ligand free | | Descriptor: | 43.2 kDa salivary protein, CITRIC ACID | | Authors: | Andersen, J.F, Xu, X, Chang, B.W, Collin, N, Valenzuela, J.G, Ribeiro, J.M. | | Deposit date: | 2011-01-03 | | Release date: | 2011-07-27 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.93 Å) | | Cite: | Structure and function of a "yellow" protein from saliva of the sand fly Lutzomyia longipalpis that confers protective immunity against Leishmania major infection.
J.Biol.Chem., 286, 2011
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3Q6P
 | | Salivary protein from Lutzomyia longipalpis. Selenomethionine derivative | | Descriptor: | 43.2 kDa salivary protein, CITRIC ACID | | Authors: | Andersen, J.F, Xu, X, Chang, B.W, Collin, N, Valenzuela, J.G, Ribeiro, J.M. | | Deposit date: | 2011-01-03 | | Release date: | 2011-07-27 | | Last modified: | 2019-10-23 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Structure and function of a "yellow" protein from saliva of the sand fly Lutzomyia longipalpis that confers protective immunity against Leishmania major infection.
J.Biol.Chem., 286, 2011
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3Q6K
 | | Salivary protein from Lutzomyia longipalpis | | Descriptor: | 43.2 kDa salivary protein, CITRIC ACID, SEROTONIN | | Authors: | Andersen, J.F, Xu, X, Chang, B.W, Collin, N, Valenzuela, J.G, Ribeiro, J.M. | | Deposit date: | 2011-01-02 | | Release date: | 2011-07-27 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.52 Å) | | Cite: | Structure and function of a "yellow" protein from saliva of the sand fly Lutzomyia longipalpis that confers protective immunity against Leishmania major infection.
J.Biol.Chem., 286, 2011
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6XKE
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6XL7
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6XMB
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5K6D
 | | Structure of FS50 an antagonist of NaV1.5 | | Descriptor: | Putative secreted salivary protein | | Authors: | Andersen, J.F, Xu, X. | | Deposit date: | 2016-05-24 | | Release date: | 2016-11-23 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.139 Å) | | Cite: | Structure and Function of FS50, a salivary protein from the flea Xenopsylla cheopis that blocks the sodium channel NaV1.5.
Sci Rep, 6, 2016
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3LH4
 | | Crystal Structure of Sialostatin L2 | | Descriptor: | GLYCEROL, SULFATE ION, Secreted cystatin | | Authors: | Andersen, J.F, Kotsyfakis, M, Salat, J, Horka, H. | | Deposit date: | 2010-01-21 | | Release date: | 2010-09-29 | | Last modified: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The crystal structures of two salivary cystatins from the tick Ixodes scapularis and the effect of these inhibitors on the establishment of Borrelia burgdorferi infection in a murine model.
Mol.Microbiol., 77, 2010
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4TPV
 | | Crystal Structure of Hookworm Platelet Inhibitor | | Descriptor: | GLYCEROL, Platelet inhibitor | | Authors: | Andersen, J.F, Ma, D, Francischetti, I. | | Deposit date: | 2014-06-09 | | Release date: | 2015-04-22 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | The structure of hookworm platelet inhibitor (HPI), a CAP superfamily member from Ancylostoma caninum.
Acta Crystallogr.,Sect.F, 71, 2015
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3MWZ
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3NGV
 | | Crystal structure of AnSt-D7L1 | | Descriptor: | D7 protein, GLYCEROL, SULFATE ION | | Authors: | Andersen, J.F, Alvarenga, P.H, Francischetti, I.M, Ribeiro, J.M, Calvo, E. | | Deposit date: | 2010-06-13 | | Release date: | 2010-12-29 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.76 Å) | | Cite: | The function and three-dimensional structure of a thromboxane a(2)/cysteinyl leukotriene-binding protein from the saliva of a mosquito vector of the malaria parasite.
Plos Biol., 8, 2010
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3NHI
 | | Crystal structure of the AnSt-D7L1-leukotriene C4 complex | | Descriptor: | (5S,7E,9E,11Z,14Z)-5-hydroxyicosa-7,9,11,14-tetraenoic acid, D7 protein, GLYCEROL, ... | | Authors: | Andersen, J.F, Alvarenga, P.H, Francischetti, I.M, Calvo, E, Sa-Nunes, A, Ribeiro, J.M. | | Deposit date: | 2010-06-14 | | Release date: | 2010-12-29 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.43 Å) | | Cite: | The function and three-dimensional structure of a thromboxane a(2)/cysteinyl leukotriene-binding protein from the saliva of a mosquito vector of the malaria parasite.
Plos Biol., 8, 2010
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