4ZM8
 
 | | Crystal Structure of Sialostatin L | | Descriptor: | Putative secreted cystatin | | Authors: | Andersen, J.F, Kosyfakis, M. | | Deposit date: | 2015-05-02 | | Release date: | 2015-06-17 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.6762 Å) | | Cite: | The crystal structures of two salivary cystatins from the tick Ixodes scapularis and the effect of these inhibitors on the establishment of Borrelia burgdorferi infection in a murine model.
Mol. Microbiol., 77, 2010
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5V13
 | | Mosquito juvenile hormone-binding protein | | Descriptor: | AAEL008620-PA odorant-binding protein, methyl (2E,6E)-9-[(2R)-3,3-dimethyloxiran-2-yl]-3,7-dimethylnona-2,6-dienoate | | Authors: | Andersen, J.F, Kim, I.H. | | Deposit date: | 2017-03-01 | | Release date: | 2017-08-09 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | A mosquito hemolymph odorant-binding protein family member specifically binds juvenile hormone.
J. Biol. Chem., 292, 2017
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4OZD
 | | Crystal structure of PdSP15a | | Descriptor: | 14.4 kDa salivary protein | | Authors: | Andersen, J.F, Alvarenga, P.H. | | Deposit date: | 2014-02-14 | | Release date: | 2015-03-04 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Protection against cutaneous leishmaniasis in non-human primates by immunization with an insect salivary protein
To be published
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6MT7
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6MTF
 | | D7 protein from Phlebotomus duboscqi, native | | Descriptor: | 26.7 kDa salivary protein, FRAGMENT OF TRITON X-100 | | Authors: | Andersen, J.F, Jablonka, W. | | Deposit date: | 2018-10-19 | | Release date: | 2019-04-10 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.92 Å) | | Cite: | Functional and structural similarities of D7 proteins in the independently-evolved salivary secretions of sand flies and mosquitoes.
Sci Rep, 9, 2019
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8EO2
 | | Lufaxin a bifunctional inhibitor of complement and coagulation | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BROMIDE ION, ... | | Authors: | Andersen, J.F, Strayer, E.C. | | Deposit date: | 2022-10-01 | | Release date: | 2023-08-09 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism.
Blood, 141, 2023
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8ENU
 | | Structure of the C3bB proconvertase in complex with lufaxin | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3 beta chain, Complement C3b alpha' chain, ... | | Authors: | Andersen, J.F, Lei, H. | | Deposit date: | 2022-09-30 | | Release date: | 2023-08-09 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.22 Å) | | Cite: | A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism.
Blood, 141, 2023
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8EOK
 | | Structure of the C3bB proconvertase in complex with lufaxin and factor Xa | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Activated factor Xa heavy chain, Complement C3 beta chain, ... | | Authors: | Andersen, J.F, Lei, H. | | Deposit date: | 2022-10-03 | | Release date: | 2023-08-30 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.53 Å) | | Cite: | A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism.
Blood, 141, 2023
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5H9N
 | | Crystal structure of LTBP1 Y114A mutant in complex with leukotriene C4 | | Descriptor: | (5~{S},6~{R},7~{E},9~{E},11~{Z},14~{Z})-6-[(2~{R})-2-[[(4~{S})-4-azanyl-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]-3-( 2-hydroxy-2-oxoethylamino)-3-oxidanylidene-propyl]sulfanyl-5-oxidanyl-icosa-7,9,11,14-tetraenoic acid, Lipocalin AI-4 | | Authors: | Andersen, J.F. | | Deposit date: | 2015-12-28 | | Release date: | 2016-05-11 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.28 Å) | | Cite: | Structure and Ligand-Binding Mechanism of a Cysteinyl Leukotriene-Binding Protein from a Blood-Feeding Disease Vector.
Acs Chem.Biol., 11, 2016
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5H9L
 | | Crystal Structure of LTBP1 in complex with cleaved Leukotriene C4 | | Descriptor: | (5S,7E,9E,11Z,14Z)-5-hydroxyicosa-7,9,11,14-tetraenoic acid, GLUTATHIONE, Lipocalin AI-4 | | Authors: | Andersen, J.F. | | Deposit date: | 2015-12-28 | | Release date: | 2016-05-11 | | Last modified: | 2025-04-02 | | Method: | X-RAY DIFFRACTION (1.37 Å) | | Cite: | Structure and Ligand-Binding Mechanism of a Cysteinyl Leukotriene-Binding Protein from a Blood-Feeding Disease Vector.
Acs Chem.Biol., 11, 2016
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5HA0
 | | Crystal structure of the LTBP1 leukotriene d4 complex | | Descriptor: | (5~{S},6~{R},7~{E},9~{E},11~{Z},14~{Z})-6-[(2~{R})-2-azanyl-3-(2-hydroxy-2-oxoethylamino)-3-oxidanylidene-propyl]sulfanyl-5-oxidanyl-icosa-7,9,11,14-tetraenoic acid, Lipocalin AI-4 | | Authors: | Andersen, J.F. | | Deposit date: | 2015-12-29 | | Release date: | 2016-05-11 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.441 Å) | | Cite: | Structure and Ligand-Binding Mechanism of a Cysteinyl Leukotriene-Binding Protein from a Blood-Feeding Disease Vector.
Acs Chem.Biol., 11, 2016
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5HAE
 | | Crystal structure of LTBP1 LTC4 complex collected on an in-house source | | Descriptor: | (5S,7E,9E,11Z,14Z)-5-hydroxyicosa-7,9,11,14-tetraenoic acid, GLUTATHIONE, Lipocalin AI-4 | | Authors: | Andersen, J.F. | | Deposit date: | 2015-12-30 | | Release date: | 2016-05-11 | | Last modified: | 2025-04-02 | | Method: | X-RAY DIFFRACTION (2.002 Å) | | Cite: | Structure and Ligand-Binding Mechanism of a Cysteinyl Leukotriene-Binding Protein from a Blood-Feeding Disease Vector.
Acs Chem.Biol., 11, 2016
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5H9K
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8UIN
 | | Structure of the C3bBb-albicin complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Albicin, ... | | Authors: | Andersen, J.F, Lei, H. | | Deposit date: | 2023-10-10 | | Release date: | 2024-05-08 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (3.86 Å) | | Cite: | Mechanism of complement inhibition by a mosquito protein revealed through cryo-EM.
Commun Biol, 7, 2024
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8UH2
 | | Complex of C3b with the inhibitor albicin | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Albicin, Complement C3 beta chain, ... | | Authors: | Andersen, J.F, Lei, H, Strayer, E, Ribeiro, J.M. | | Deposit date: | 2023-10-06 | | Release date: | 2024-05-08 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (3.59 Å) | | Cite: | Mechanism of complement inhibition by a mosquito protein revealed through cryo-EM.
Commun Biol, 7, 2024
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6XKE
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6XL7
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6XMB
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4GE1
 | | Structure of the tryptamine complex of the amine binding protein of Rhodnius prolixus | | Descriptor: | 2-(1H-INDOL-3-YL)ETHANAMINE, Biogenic amine-binding protein, GLYCEROL | | Authors: | Andersen, J.F, Chang, B.W, Xu, X, Mans, B.J, Ribeiro, J.M. | | Deposit date: | 2012-08-01 | | Release date: | 2013-01-02 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structure and ligand-binding properties of the biogenic amine-binding protein from the saliva of a blood-feeding insect vector of Trypanosoma cruzi.
Acta Crystallogr.,Sect.D, 69, 2013
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4GET
 | | Crystal structure of biogenic amine binding protein from Rhodnius prolixus | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Biogenic amine-binding protein | | Authors: | Andersen, J.F, Chang, B.W, Xu, X, Mans, B.J, Ribeiro, J.M. | | Deposit date: | 2012-08-02 | | Release date: | 2013-01-02 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.24 Å) | | Cite: | Structure and ligand-binding properties of the biogenic amine-binding protein from the saliva of a blood-feeding insect vector of Trypanosoma cruzi.
Acta Crystallogr.,Sect.D, 69, 2013
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4JD9
 | | Contact pathway inhibitor from a sand fly | | Descriptor: | 14.5 kDa salivary protein, SULFATE ION | | Authors: | Andersen, J.F, Xu, X, Alvarenga, P. | | Deposit date: | 2013-02-24 | | Release date: | 2013-10-16 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (2.601 Å) | | Cite: | Novel family of insect salivary inhibitors blocks contact pathway activation by binding to polyphosphate, heparin, and dextran sulfate.
Arterioscler Thromb Vasc Biol, 33, 2013
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4HFO
 | | Biogenic amine-binding protein selenomethionine derivative | | Descriptor: | Biogenic amine-binding protein | | Authors: | Andersen, J.F, Xu, X, Chang, B, Mans, B.J, Ribeiro, J.M. | | Deposit date: | 2012-10-05 | | Release date: | 2013-01-02 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structure and ligand-binding properties of the biogenic amine-binding protein from the saliva of a blood-feeding insect vector of Trypanosoma cruzi.
Acta Crystallogr.,Sect.D, 69, 2013
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3NGV
 | | Crystal structure of AnSt-D7L1 | | Descriptor: | D7 protein, GLYCEROL, SULFATE ION | | Authors: | Andersen, J.F, Alvarenga, P.H, Francischetti, I.M, Ribeiro, J.M, Calvo, E. | | Deposit date: | 2010-06-13 | | Release date: | 2010-12-29 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.76 Å) | | Cite: | The function and three-dimensional structure of a thromboxane a(2)/cysteinyl leukotriene-binding protein from the saliva of a mosquito vector of the malaria parasite.
Plos Biol., 8, 2010
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3NHI
 | | Crystal structure of the AnSt-D7L1-leukotriene C4 complex | | Descriptor: | (5S,7E,9E,11Z,14Z)-5-hydroxyicosa-7,9,11,14-tetraenoic acid, D7 protein, GLYCEROL, ... | | Authors: | Andersen, J.F, Alvarenga, P.H, Francischetti, I.M, Calvo, E, Sa-Nunes, A, Ribeiro, J.M. | | Deposit date: | 2010-06-14 | | Release date: | 2010-12-29 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.43 Å) | | Cite: | The function and three-dimensional structure of a thromboxane a(2)/cysteinyl leukotriene-binding protein from the saliva of a mosquito vector of the malaria parasite.
Plos Biol., 8, 2010
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3NHT
 | | Crystal structure of the AnSt-D7L1-U46619 complex | | Descriptor: | (5E)-7-{6-[(1E)-3-HYDROXYOCT-1-ENYL]-2-OXABICYCLO[2.2.1]HEPT-5-YL}HEPT-5-ENOIC ACID, D7 protein, SULFATE ION | | Authors: | Andersen, J.F, Alvarenga, P.H, Francischetti, I.M, Calvo, E, Sa-Nunes, A, Ribeiro, J.M. | | Deposit date: | 2010-06-14 | | Release date: | 2010-12-29 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | The function and three-dimensional structure of a thromboxane a(2)/cysteinyl leukotriene-binding protein from the saliva of a mosquito vector of the malaria parasite.
Plos Biol., 8, 2010
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