8EO2

Lufaxin a bifunctional inhibitor of complement and coagulation

Summary for 8EO2

• Entry DOI: 10.2210/pdb8eo2/pdb
• Descriptor: Lufaxin, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: complement, coagulation, sand fly, salivary, inhibitor, blood clotting
• Biological source: Lutzomyia longipalpis
• Total number of polymer chains: 2
• Total formula weight: 68654.15

Authors

Andersen, J.F.,Strayer, E.C. (deposition date: 2022-10-01, release date: 2023-08-09, Last modification date: 2024-02-21)

• Primary citation: Andersen, J.F.,Lei, H.,Strayer, E.C.,Kanai, T.,Pham, V.,Pan, X.Z.,Alvarenga, P.H.,Gerber, G.F.,Asojo, O.A.,Francischetti, I.M.B.,Brodsky, R.A.,Valenzuela, J.G.,Ribeiro, J.M.C.; A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism.; Blood, 141:3109-3121, 2023; PubMed: 36947859; DOI: 10.1182/blood.2022019359

Experimental method

X-RAY DIFFRACTION (2.31 Å)