8EO2

Lufaxin a bifunctional inhibitor of complement and coagulation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Lufaxin	polymer	284	33354.6	2	UniProt (Q5WPU8)	Lutzomyia longipalpis	32.4 kDa salivary protein,Lutzomyia longipalpis FXa inhibitor
2	C (C)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	1	In PDB GlyTouCan (G15407YE)
3	D (D)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
4	E (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
5	F, J (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
6	G, H, I, K, L (A, B)	BROMIDE ION	non-polymer		79.9	5	Chemie (BR)
7	M, N (A, B)	water	water		18.0	143	Chemie (HOH)

Sequence modifications

A, B: 1 - 278 (UniProt: Q5WPU8)

PDB	External Database	Details
Arg 75	Lys 98	conflict
Ser 134	Pro 157	conflict
Leu 145	Val 168	conflict
Asn 148	Tyr 171	conflict
His 279	-	expression tag
His 280	-	expression tag
His 281	-	expression tag
His 282	-	expression tag
His 283	-	expression tag
His 284	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	66709.2
Branched	Number of molecules	2
	Total formula weight	1010.9
Non-Polymers*	Number of molecules	8
	Total formula weight	934.0
All*	Total formula weight	68654.1

*Water molecules are not included.