2QEH
| Crystal Structure of Anopheles gambiae D7r4-serotonin complex | Descriptor: | D7R4 Protein, SEROTONIN | Authors: | Andersen, J.F, Mans, B.J, Calvo, E, Ribeiro, J.M. | Deposit date: | 2007-06-25 | Release date: | 2007-10-09 | Last modified: | 2017-10-18 | Method: | X-RAY DIFFRACTION (2.102 Å) | Cite: | The Crystal Structure of D7r4, a Salivary Biogenic Amine-binding Protein from the Malaria Mosquito Anopheles gambiae J.Biol.Chem., 282, 2007
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3U3L
| Crystal structure of the selenomethionine derivative of tablysin-15 | Descriptor: | CITRIC ACID, PALMITIC ACID, PRASEODYMIUM ION, ... | Authors: | Andersen, J.F, Xu, X, Ribeiro, J.M. | Deposit date: | 2011-10-06 | Release date: | 2012-02-15 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Structure of protein having inhibitory disintegrin and leukotriene scavenging functions contained in single domain. J.Biol.Chem., 287, 2012
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3U3U
| Crystal structure of the tablysin-15-leukotriene E4 complex | Descriptor: | (5S,7E,9E,11Z,14Z)-5-hydroxyicosa-7,9,11,14-tetraenoic acid, CITRIC ACID, PRASEODYMIUM ION, ... | Authors: | Andersen, J.F. | Deposit date: | 2011-10-06 | Release date: | 2012-02-15 | Last modified: | 2015-01-28 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of protein having inhibitory disintegrin and leukotriene scavenging functions contained in single domain. J.Biol.Chem., 287, 2012
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4N7E
| Crystal structure of the Vps10p domain of human sortilin/NTS3 in complex with AF38469 | Descriptor: | 2-[(6-methylpyridin-2-yl)carbamoyl]-5-(trifluoromethyl)benzoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Sortilin, ... | Authors: | Andersen, J.L, Strandbygaard, D, Thirup, S. | Deposit date: | 2013-10-15 | Release date: | 2014-01-22 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The identification of AF38469: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. Bioorg.Med.Chem.Lett., 24, 2014
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4MSL
| Crystal structure of the Vps10p domain of human sortilin/NTS3 in complex with AF40431 | Descriptor: | N-[(7-hydroxy-4-methyl-2-oxo-2H-chromen-8-yl)methyl]-L-leucine, Sortilin, TETRAETHYLENE GLYCOL, ... | Authors: | Andersen, J.L, Strandbygaard, D, Thirup, S. | Deposit date: | 2013-09-18 | Release date: | 2014-02-12 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor-ligand complex. Acta Crystallogr.,Sect.D, 70, 2014
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6XKE
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8ENU
| Structure of the C3bB proconvertase in complex with lufaxin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3 beta chain, Complement C3b alpha' chain, ... | Authors: | Andersen, J.F, Lei, H. | Deposit date: | 2022-09-30 | Release date: | 2023-08-09 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.22 Å) | Cite: | A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism. Blood, 141, 2023
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8EO2
| Lufaxin a bifunctional inhibitor of complement and coagulation | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BROMIDE ION, ... | Authors: | Andersen, J.F, Strayer, E.C. | Deposit date: | 2022-10-01 | Release date: | 2023-08-09 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism. Blood, 141, 2023
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8EOK
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6XL7
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6XMB
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7TVY
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7TX8
| Long form D7 protein from Anopheles darlingi with U46619 and serotonin bound | Descriptor: | (5Z)-7-{(1R,4S,5S,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid, Long form D7 salivary protein, SEROTONIN | Authors: | Andersen, J.F, Alvarenga, P.H. | Deposit date: | 2022-02-08 | Release date: | 2022-06-01 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Functional aspects of evolution in a cluster of salivary protein genes from mosquitoes. Insect Biochem.Mol.Biol., 146, 2022
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7TVC
| Short form D7 protein from Aedes aegypti | Descriptor: | Salivary short D7 protein | Authors: | Andersen, J.F, Xu, X. | Deposit date: | 2022-02-04 | Release date: | 2022-05-25 | Method: | X-RAY DIFFRACTION (1.19 Å) | Cite: | Functional aspects of evolution in a cluster of salivary protein genes from mosquitoes. Insect Biochem.Mol.Biol., 146, 2022
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6MT7
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6MTF
| D7 protein from Phlebotomus duboscqi, native | Descriptor: | 26.7 kDa salivary protein, FRAGMENT OF TRITON X-100 | Authors: | Andersen, J.F, Jablonka, W. | Deposit date: | 2018-10-19 | Release date: | 2019-04-10 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Functional and structural similarities of D7 proteins in the independently-evolved salivary secretions of sand flies and mosquitoes. Sci Rep, 9, 2019
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4TPV
| Crystal Structure of Hookworm Platelet Inhibitor | Descriptor: | GLYCEROL, Platelet inhibitor | Authors: | Andersen, J.F, Ma, D, Francischetti, I. | Deposit date: | 2014-06-09 | Release date: | 2015-04-22 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The structure of hookworm platelet inhibitor (HPI), a CAP superfamily member from Ancylostoma caninum. Acta Crystallogr.,Sect.F, 71, 2015
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8UIN
| Structure of the C3bBb-albicin complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Albicin, ... | Authors: | Andersen, J.F, Lei, H. | Deposit date: | 2023-10-10 | Release date: | 2024-05-08 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.86 Å) | Cite: | Mechanism of complement inhibition by a mosquito protein revealed through cryo-EM. Commun Biol, 7, 2024
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8UH2
| Complex of C3b with the inhibitor albicin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Albicin, Complement C3 beta chain, ... | Authors: | Andersen, J.F, Lei, H, Strayer, E, Ribeiro, J.M. | Deposit date: | 2023-10-06 | Release date: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.59 Å) | Cite: | The mechanism of a mosquito salivary inhibitor of the alternative C3 convertase is elucidated through structural analysis of its complex with C3bBb To Be Published
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4GE1
| Structure of the tryptamine complex of the amine binding protein of Rhodnius prolixus | Descriptor: | 2-(1H-INDOL-3-YL)ETHANAMINE, Biogenic amine-binding protein, GLYCEROL | Authors: | Andersen, J.F, Chang, B.W, Xu, X, Mans, B.J, Ribeiro, J.M. | Deposit date: | 2012-08-01 | Release date: | 2013-01-02 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structure and ligand-binding properties of the biogenic amine-binding protein from the saliva of a blood-feeding insect vector of Trypanosoma cruzi. Acta Crystallogr.,Sect.D, 69, 2013
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4GET
| Crystal structure of biogenic amine binding protein from Rhodnius prolixus | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Biogenic amine-binding protein | Authors: | Andersen, J.F, Chang, B.W, Xu, X, Mans, B.J, Ribeiro, J.M. | Deposit date: | 2012-08-02 | Release date: | 2013-01-02 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Structure and ligand-binding properties of the biogenic amine-binding protein from the saliva of a blood-feeding insect vector of Trypanosoma cruzi. Acta Crystallogr.,Sect.D, 69, 2013
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4HFO
| Biogenic amine-binding protein selenomethionine derivative | Descriptor: | Biogenic amine-binding protein | Authors: | Andersen, J.F, Xu, X, Chang, B, Mans, B.J, Ribeiro, J.M. | Deposit date: | 2012-10-05 | Release date: | 2013-01-02 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure and ligand-binding properties of the biogenic amine-binding protein from the saliva of a blood-feeding insect vector of Trypanosoma cruzi. Acta Crystallogr.,Sect.D, 69, 2013
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4JD9
| Contact pathway inhibitor from a sand fly | Descriptor: | 14.5 kDa salivary protein, SULFATE ION | Authors: | Andersen, J.F, Xu, X, Alvarenga, P. | Deposit date: | 2013-02-24 | Release date: | 2013-10-16 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.601 Å) | Cite: | Novel family of insect salivary inhibitors blocks contact pathway activation by binding to polyphosphate, heparin, and dextran sulfate. Arterioscler Thromb Vasc Biol, 33, 2013
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4OZD
| Crystal structure of PdSP15a | Descriptor: | 14.4 kDa salivary protein | Authors: | Andersen, J.F, Alvarenga, P.H. | Deposit date: | 2014-02-14 | Release date: | 2015-03-04 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Protection against cutaneous leishmaniasis in non-human primates by immunization with an insect salivary protein To be published
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5K6D
| Structure of FS50 an antagonist of NaV1.5 | Descriptor: | Putative secreted salivary protein | Authors: | Andersen, J.F, Xu, X. | Deposit date: | 2016-05-24 | Release date: | 2016-11-23 | Method: | X-RAY DIFFRACTION (1.139 Å) | Cite: | Structure and Function of FS50, a salivary protein from the flea Xenopsylla cheopis that blocks the sodium channel NaV1.5. Sci Rep, 6, 2016
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