5V13
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![BU of 5v13 by Molmil](/molmil-images/mine/5v13) | Mosquito juvenile hormone-binding protein | Descriptor: | AAEL008620-PA odorant-binding protein, methyl (2E,6E)-9-[(2R)-3,3-dimethyloxiran-2-yl]-3,7-dimethylnona-2,6-dienoate | Authors: | Andersen, J.F, Kim, I.H. | Deposit date: | 2017-03-01 | Release date: | 2017-08-09 | Last modified: | 2017-09-27 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | A mosquito hemolymph odorant-binding protein family member specifically binds juvenile hormone. J. Biol. Chem., 292, 2017
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5K6D
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![BU of 5k6d by Molmil](/molmil-images/mine/5k6d) | Structure of FS50 an antagonist of NaV1.5 | Descriptor: | Putative secreted salivary protein | Authors: | Andersen, J.F, Xu, X. | Deposit date: | 2016-05-24 | Release date: | 2016-11-23 | Method: | X-RAY DIFFRACTION (1.139 Å) | Cite: | Structure and Function of FS50, a salivary protein from the flea Xenopsylla cheopis that blocks the sodium channel NaV1.5. Sci Rep, 6, 2016
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8EO2
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![BU of 8eo2 by Molmil](/molmil-images/mine/8eo2) | Lufaxin a bifunctional inhibitor of complement and coagulation | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BROMIDE ION, ... | Authors: | Andersen, J.F, Strayer, E.C. | Deposit date: | 2022-10-01 | Release date: | 2023-08-09 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism. Blood, 141, 2023
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8ENU
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![BU of 8enu by Molmil](/molmil-images/mine/8enu) | Structure of the C3bB proconvertase in complex with lufaxin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3 beta chain, Complement C3b alpha' chain, ... | Authors: | Andersen, J.F, Lei, H. | Deposit date: | 2022-09-30 | Release date: | 2023-08-09 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.22 Å) | Cite: | A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism. Blood, 141, 2023
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8EOK
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![BU of 8eok by Molmil](/molmil-images/mine/8eok) | |
6MT7
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![BU of 6mt7 by Molmil](/molmil-images/mine/6mt7) | |
6MTF
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![BU of 6mtf by Molmil](/molmil-images/mine/6mtf) | D7 protein from Phlebotomus duboscqi, native | Descriptor: | 26.7 kDa salivary protein, FRAGMENT OF TRITON X-100 | Authors: | Andersen, J.F, Jablonka, W. | Deposit date: | 2018-10-19 | Release date: | 2019-04-10 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Functional and structural similarities of D7 proteins in the independently-evolved salivary secretions of sand flies and mosquitoes. Sci Rep, 9, 2019
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6XKE
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![BU of 6xke by Molmil](/molmil-images/mine/6xke) | |
6XL7
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![BU of 6xl7 by Molmil](/molmil-images/mine/6xl7) | |
6XMB
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![BU of 6xmb by Molmil](/molmil-images/mine/6xmb) | |
7TVY
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![BU of 7tvy by Molmil](/molmil-images/mine/7tvy) | |
8UIN
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![BU of 8uin by Molmil](/molmil-images/mine/8uin) | Structure of the C3bBb-albicin complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Albicin, ... | Authors: | Andersen, J.F, Lei, H. | Deposit date: | 2023-10-10 | Release date: | 2024-05-08 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.86 Å) | Cite: | Mechanism of complement inhibition by a mosquito protein revealed through cryo-EM. Commun Biol, 7, 2024
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8UH2
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![BU of 8uh2 by Molmil](/molmil-images/mine/8uh2) | Complex of C3b with the inhibitor albicin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Albicin, Complement C3 beta chain, ... | Authors: | Andersen, J.F, Lei, H, Strayer, E, Ribeiro, J.M. | Deposit date: | 2023-10-06 | Release date: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.59 Å) | Cite: | The mechanism of a mosquito salivary inhibitor of the alternative C3 convertase is elucidated through structural analysis of its complex with C3bBb To Be Published
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7TX8
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![BU of 7tx8 by Molmil](/molmil-images/mine/7tx8) | Long form D7 protein from Anopheles darlingi with U46619 and serotonin bound | Descriptor: | (5Z)-7-{(1R,4S,5S,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid, Long form D7 salivary protein, SEROTONIN | Authors: | Andersen, J.F, Alvarenga, P.H. | Deposit date: | 2022-02-08 | Release date: | 2022-06-01 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Functional aspects of evolution in a cluster of salivary protein genes from mosquitoes. Insect Biochem.Mol.Biol., 146, 2022
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7TVC
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![BU of 7tvc by Molmil](/molmil-images/mine/7tvc) | Short form D7 protein from Aedes aegypti | Descriptor: | Salivary short D7 protein | Authors: | Andersen, J.F, Xu, X. | Deposit date: | 2022-02-04 | Release date: | 2022-05-25 | Method: | X-RAY DIFFRACTION (1.19 Å) | Cite: | Functional aspects of evolution in a cluster of salivary protein genes from mosquitoes. Insect Biochem.Mol.Biol., 146, 2022
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5MRI
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![BU of 5mri by Molmil](/molmil-images/mine/5mri) | Crystal structure of the Vps10p domain of human sortilin/NTS3 in complex with Triazolone 18 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Sortilin, ... | Authors: | Andersen, J.L, Strandbygaard, D, Thirup, S. | Deposit date: | 2016-12-23 | Release date: | 2017-05-17 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The identification of novel acid isostere based inhibitors of the VPS10P family sorting receptor Sortilin. Bioorg. Med. Chem. Lett., 27, 2017
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5MRH
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![BU of 5mrh by Molmil](/molmil-images/mine/5mrh) | Crystal structure of the Vps10p domain of human sortilin/NTS3 in complex with Triazolone 1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(3-methylbutyl)-4~{H}-1,2,3-triazol-5-one, Sortilin, ... | Authors: | Andersen, J.L, Strandbygaard, D, Thirup, S. | Deposit date: | 2016-12-23 | Release date: | 2017-05-17 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The identification of novel acid isostere based inhibitors of the VPS10P family sorting receptor Sortilin. Bioorg. Med. Chem. Lett., 27, 2017
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4TPV
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![BU of 4tpv by Molmil](/molmil-images/mine/4tpv) | Crystal Structure of Hookworm Platelet Inhibitor | Descriptor: | GLYCEROL, Platelet inhibitor | Authors: | Andersen, J.F, Ma, D, Francischetti, I. | Deposit date: | 2014-06-09 | Release date: | 2015-04-22 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The structure of hookworm platelet inhibitor (HPI), a CAP superfamily member from Ancylostoma caninum. Acta Crystallogr.,Sect.F, 71, 2015
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4JD9
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![BU of 4jd9 by Molmil](/molmil-images/mine/4jd9) | Contact pathway inhibitor from a sand fly | Descriptor: | 14.5 kDa salivary protein, SULFATE ION | Authors: | Andersen, J.F, Xu, X, Alvarenga, P. | Deposit date: | 2013-02-24 | Release date: | 2013-10-16 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.601 Å) | Cite: | Novel family of insect salivary inhibitors blocks contact pathway activation by binding to polyphosphate, heparin, and dextran sulfate. Arterioscler Thromb Vasc Biol, 33, 2013
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3Q6T
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![BU of 3q6t by Molmil](/molmil-images/mine/3q6t) | Salivary protein from Lutzomyia longipalpis, Ligand free | Descriptor: | 43.2 kDa salivary protein, CITRIC ACID | Authors: | Andersen, J.F, Xu, X, Chang, B.W, Collin, N, Valenzuela, J.G, Ribeiro, J.M. | Deposit date: | 2011-01-03 | Release date: | 2011-07-27 | Last modified: | 2019-10-23 | Method: | X-RAY DIFFRACTION (2.93 Å) | Cite: | Structure and function of a "yellow" protein from saliva of the sand fly Lutzomyia longipalpis that confers protective immunity against Leishmania major infection. J.Biol.Chem., 286, 2011
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3Q6P
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![BU of 3q6p by Molmil](/molmil-images/mine/3q6p) | Salivary protein from Lutzomyia longipalpis. Selenomethionine derivative | Descriptor: | 43.2 kDa salivary protein, CITRIC ACID | Authors: | Andersen, J.F, Xu, X, Chang, B.W, Collin, N, Valenzuela, J.G, Ribeiro, J.M. | Deposit date: | 2011-01-03 | Release date: | 2011-07-27 | Last modified: | 2019-10-23 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structure and function of a "yellow" protein from saliva of the sand fly Lutzomyia longipalpis that confers protective immunity against Leishmania major infection. J.Biol.Chem., 286, 2011
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3Q6K
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![BU of 3q6k by Molmil](/molmil-images/mine/3q6k) | Salivary protein from Lutzomyia longipalpis | Descriptor: | 43.2 kDa salivary protein, CITRIC ACID, SEROTONIN | Authors: | Andersen, J.F, Xu, X, Chang, B.W, Collin, N, Valenzuela, J.G, Ribeiro, J.M. | Deposit date: | 2011-01-02 | Release date: | 2011-07-27 | Last modified: | 2019-10-23 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Structure and function of a "yellow" protein from saliva of the sand fly Lutzomyia longipalpis that confers protective immunity against Leishmania major infection. J.Biol.Chem., 286, 2011
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4OZD
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![BU of 4ozd by Molmil](/molmil-images/mine/4ozd) | Crystal structure of PdSP15a | Descriptor: | 14.4 kDa salivary protein | Authors: | Andersen, J.F, Alvarenga, P.H. | Deposit date: | 2014-02-14 | Release date: | 2015-03-04 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Protection against cutaneous leishmaniasis in non-human primates by immunization with an insect salivary protein To be published
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4GE1
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![BU of 4ge1 by Molmil](/molmil-images/mine/4ge1) | Structure of the tryptamine complex of the amine binding protein of Rhodnius prolixus | Descriptor: | 2-(1H-INDOL-3-YL)ETHANAMINE, Biogenic amine-binding protein, GLYCEROL | Authors: | Andersen, J.F, Chang, B.W, Xu, X, Mans, B.J, Ribeiro, J.M. | Deposit date: | 2012-08-01 | Release date: | 2013-01-02 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structure and ligand-binding properties of the biogenic amine-binding protein from the saliva of a blood-feeding insect vector of Trypanosoma cruzi. Acta Crystallogr.,Sect.D, 69, 2013
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4GET
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![BU of 4get by Molmil](/molmil-images/mine/4get) | Crystal structure of biogenic amine binding protein from Rhodnius prolixus | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Biogenic amine-binding protein | Authors: | Andersen, J.F, Chang, B.W, Xu, X, Mans, B.J, Ribeiro, J.M. | Deposit date: | 2012-08-02 | Release date: | 2013-01-02 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Structure and ligand-binding properties of the biogenic amine-binding protein from the saliva of a blood-feeding insect vector of Trypanosoma cruzi. Acta Crystallogr.,Sect.D, 69, 2013
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