5JCT
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6H1H
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![BU of 6h1h by Molmil](/molmil-images/mine/6h1h) | Crystal structure of human Pirin in complex with compound 7 (PLX4720) | Descriptor: | 1,2-ETHANEDIOL, FE (III) ION, GLYCEROL, ... | Authors: | Ali, S, Le Bihan, Y.V, van Montfort, R.L.M. | Deposit date: | 2018-07-11 | Release date: | 2018-11-28 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Privileged Structures and Polypharmacology within and between Protein Families. ACS Med Chem Lett, 9, 2018
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6H1I
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![BU of 6h1i by Molmil](/molmil-images/mine/6h1i) | Crystal structure of human Pirin in complex with bisamide compound 2 | Descriptor: | FE (III) ION, GLYCEROL, Pirin, ... | Authors: | Ali, S, Le Bihan, Y.V, van Montfort, R.L.M. | Deposit date: | 2018-07-11 | Release date: | 2018-11-28 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Privileged Structures and Polypharmacology within and between Protein Families. ACS Med Chem Lett, 9, 2018
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4ICG
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![BU of 4icg by Molmil](/molmil-images/mine/4icg) | N-terminal dimerization domain of H-NS in complex with Hha (Salmonella Typhimurium) | Descriptor: | DNA-binding protein H-NS, Hemolysin expression modulating protein (Involved in environmental regulation of virulence factors) | Authors: | Ali, S.S, Whitney, J.C, Stevenson, J, Robinson, H, Howell, P.L, Navarre, W.W. | Deposit date: | 2012-12-10 | Release date: | 2013-03-27 | Last modified: | 2016-05-18 | Method: | X-RAY DIFFRACTION (2.9217 Å) | Cite: | Structural Insights into the Regulation of Foreign Genes in Salmonella by the Hha/H-NS Complex. J.Biol.Chem., 288, 2013
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6XH0
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6XH3
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6XH2
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3D54
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![BU of 3d54 by Molmil](/molmil-images/mine/3d54) | Structure of PurLQS from Thermotoga maritima | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Formylglycinamide ribonucleotide amidotransferase, Phosphoribosylformylglycinamidine synthase 1, ... | Authors: | Ealick, S.E, Morar, M. | Deposit date: | 2008-05-15 | Release date: | 2008-07-22 | Last modified: | 2017-02-01 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Formylglycinamide ribonucleotide amidotransferase from Thermotoga maritima: structural insights into complex formation. Biochemistry, 47, 2008
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8UXW
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![BU of 8uxw by Molmil](/molmil-images/mine/8uxw) | Arp2/3 branch junction complex, ADP state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | Authors: | Chavali, S.S, Chou, S.Z, Sindelar, C.V. | Deposit date: | 2023-11-11 | Release date: | 2024-01-31 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Cryo-EM structures reveal how phosphate release from Arp3 weakens actin filament branches formed by Arp2/3 complex. Nat Commun, 15, 2024
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8UXX
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![BU of 8uxx by Molmil](/molmil-images/mine/8uxx) | Arp2/3 branch junction complex, BeFx state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | Authors: | Chavali, S.S, Chou, S.Z, Sindelar, C.V. | Deposit date: | 2023-11-11 | Release date: | 2024-01-31 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cryo-EM structures reveal how phosphate release from Arp3 weakens actin filament branches formed by Arp2/3 complex. Nat Commun, 15, 2024
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8UZ1
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![BU of 8uz1 by Molmil](/molmil-images/mine/8uz1) | Straight actin filament from Arp2/3 branch junction sample (ADP-BeFx) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Chavali, S.S, Chou, S.Z, Sindelar, C.V. | Deposit date: | 2023-11-14 | Release date: | 2024-01-31 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM structures reveal how phosphate release from Arp3 weakens actin filament branches formed by Arp2/3 complex. Nat Commun, 15, 2024
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8UZ0
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![BU of 8uz0 by Molmil](/molmil-images/mine/8uz0) | Straight actin filament from Arp2/3 branch junction sample (ADP) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Chavali, S.S, Chou, S.Z, Sindelar, C.V. | Deposit date: | 2023-11-14 | Release date: | 2024-01-31 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Cryo-EM structures reveal how phosphate release from Arp3 weakens actin filament branches formed by Arp2/3 complex. Nat Commun, 15, 2024
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8U7V
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![BU of 8u7v by Molmil](/molmil-images/mine/8u7v) | Human retinal variant phosphomimetic IMPDH1(546)-S477D filament bound by GTP, ATP, IMP, and NAD+, interface-centered | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ... | Authors: | Calise, S.J, Kollman, J.M. | Deposit date: | 2023-09-15 | Release date: | 2024-01-31 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Light-sensitive phosphorylation regulates retinal IMPDH1 activity and filament assembly. J.Cell Biol., 223, 2024
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8U7M
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![BU of 8u7m by Molmil](/molmil-images/mine/8u7m) | Human retinal variant phosphomimetic IMPDH1(595)-S477D free octamer bound by GTP, ATP, IMP, and NAD+ | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ... | Authors: | Calise, S.J, Kollman, J.M. | Deposit date: | 2023-09-15 | Release date: | 2024-01-31 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Light-sensitive phosphorylation regulates retinal IMPDH1 activity and filament assembly. J.Cell Biol., 223, 2024
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5DIV
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![BU of 5div by Molmil](/molmil-images/mine/5div) | The Fk1 domain of FKBP51 in complex with the new synthetic ligand (S)-N-(1-carbamoylcyclopentyl)-1-((S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl)piperidine-2-carboxamide | Descriptor: | (2S)-N-(1-carbamoylcyclopentyl)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxamide, Peptidyl-prolyl cis-trans isomerase FKBP5 | Authors: | Gaali, S, Feng, X, Sippel, C, Bracher, A, Hausch, F. | Deposit date: | 2015-09-01 | Release date: | 2016-03-23 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Rapid, Structure-Based Exploration of Pipecolic Acid Amides as Novel Selective Antagonists of the FK506-Binding Protein 51. J.Med.Chem., 59, 2016
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5DIU
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![BU of 5diu by Molmil](/molmil-images/mine/5diu) | The Fk1 domain of FKBP51 in complex with the new synthetic ligand 2-(3-((R)-1-((S)-1-((S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl)piperidine-2-carboxamido)-3-(3,4-dimethoxyphenyl)propyl)phenoxy)acetic acid | Descriptor: | Peptidyl-prolyl cis-trans isomerase FKBP5, {3-[(1R)-1-[({(2S)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl]piperidin-2-yl}carbonyl)amino]-3-(3,4-dimethoxyphenyl)propyl]phenoxy}acetic acid | Authors: | Gaali, S, Feng, X, Sippel, C, Bracher, A, Hausch, F. | Deposit date: | 2015-09-01 | Release date: | 2016-03-23 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Rapid, Structure-Based Exploration of Pipecolic Acid Amides as Novel Selective Antagonists of the FK506-Binding Protein 51. J.Med.Chem., 59, 2016
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8BFY
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![BU of 8bfy by Molmil](/molmil-images/mine/8bfy) | ABC transporter binding protein CebE from Streptomyces scabiei in complex with cellotriose | Descriptor: | CITRIC ACID, GLYCEROL, Putative secreted cellobiose-binding (Transport system associated), ... | Authors: | Rigali, S, Jourdan, S, Kerff, F. | Deposit date: | 2022-10-27 | Release date: | 2023-02-01 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Common scab disease: structural basis of elicitor recognition in pathogenic Streptomyces species. Microbiol Spectr, 11, 2023
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4TW6
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![BU of 4tw6 by Molmil](/molmil-images/mine/4tw6) | The Fk1 domain of FKBP51 in complex with iFit1 | Descriptor: | (3-{(1R)-3-(3,4-dimethoxyphenyl)-1-[({(2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)pent-4-enoyl]piperidin-2-yl}carbonyl)oxy]propyl}phenoxy)acetic acid, GLYCEROL, Peptidyl-prolyl cis-trans isomerase FKBP5, ... | Authors: | Gaali, S, Kirschner, A, Cuboni, S, Hartmann, J, Kozany, C, Balsevich, G, Namendorf, C, Fernandez-Vizarra, P, Almeida, O.F.X, Ruehter, G, Uhr, M, Schmidt, M.V, Touma, C, Bracher, A, Hausch, F. | Deposit date: | 2014-06-30 | Release date: | 2014-11-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Selective inhibitors of the FK506-binding protein 51 by induced fit. Nat.Chem.Biol., 11, 2015
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4TW8
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![BU of 4tw8 by Molmil](/molmil-images/mine/4tw8) | The Fk1-Fk2 domains of FKBP52 in complex with iFit-FL | Descriptor: | 2-(5-{[({3-[(1R)-1-[({(2S)-1-[(2S)-2-[(1S)-cyclohex-2-en-1-yl]-2-(3,4,5-trimethoxyphenyl)acetyl]piperidin-2-yl}carbonyl)oxy]-3-(3,4-dimethoxyphenyl)propyl]phenoxy}acetyl)amino]methyl}-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid, Peptidyl-prolyl cis-trans isomerase FKBP4 | Authors: | Gaali, S, Kirschner, A, Cuboni, S, Hartmann, J, Kozany, C, Balsevich, G, Namendorf, C, Fernandez-Vizarra, P, Almeida, O.F.X, Ruehter, G, Uhr, M, Schmidt, M.V, Touma, C, Bracher, A, Hausch, F. | Deposit date: | 2014-06-30 | Release date: | 2014-11-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.003 Å) | Cite: | Selective inhibitors of the FK506-binding protein 51 by induced fit. Nat.Chem.Biol., 11, 2015
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4TW7
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![BU of 4tw7 by Molmil](/molmil-images/mine/4tw7) | The Fk1 domain of FKBP51 in complex with iFit4 | Descriptor: | (1R)-3-(3,4-dimethoxyphenyl)-1-{3-[2-(morpholin-4-yl)ethoxy]phenyl}propyl (2S)-1-[(2S)-2-[(1S)-cyclohex-2-en-1-yl]-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxylate, Peptidyl-prolyl cis-trans isomerase FKBP5 | Authors: | Gaali, S, Kirschner, A, Cuboni, S, Hartmann, J, Kozany, C, Balsevich, G, Namendorf, C, Fernandez-Vizarra, P, Almeida, O.F.X, Ruehter, G, Uhr, M, Schmidt, M.V, Touma, C, Bracher, A, Hausch, F. | Deposit date: | 2014-06-30 | Release date: | 2014-11-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Selective inhibitors of the FK506-binding protein 51 by induced fit. Nat.Chem.Biol., 11, 2015
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3HL2
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![BU of 3hl2 by Molmil](/molmil-images/mine/3hl2) | The crystal structure of the human SepSecS-tRNASec complex | Descriptor: | (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, Monothiophosphate, O-phosphoseryl-tRNA(Sec) selenium transferase, ... | Authors: | Palioura, S, Steitz, T.A, Soll, D, Simonovic, M. | Deposit date: | 2009-05-26 | Release date: | 2009-10-06 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | The human SepSecS-tRNASec complex reveals the mechanism of selenocysteine formation. Science, 325, 2009
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4CCS
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![BU of 4ccs by Molmil](/molmil-images/mine/4ccs) | The structure of CbiX, the terminal Enzyme for Biosynthesis of Siroheme in Denitrifying Bacteria | Descriptor: | 1,2-ETHANEDIOL, CBIX, D-MALATE, ... | Authors: | Bali, S, Rollauer, S.E, Roversi, P, Raux-Deery, E, Lea, S.M, Warren, M.J, Ferguson, S.J. | Deposit date: | 2013-10-25 | Release date: | 2014-04-09 | Last modified: | 2015-09-23 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Identification and Characterization of the 'Missing' Terminal Enzyme for Siroheme Biosynthesis in Alpha-Proteobacteria. Mol.Microbiol., 92, 2014
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5HFT
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![BU of 5hft by Molmil](/molmil-images/mine/5hft) | Crystal structure of HpxW | Descriptor: | Gamma-glutamyltranspeptidase | Authors: | Ealick, S.E, Hicks, K.A. | Deposit date: | 2016-01-07 | Release date: | 2016-06-29 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.646 Å) | Cite: | Biochemical and structural characterization of Klebsiella pneumoniae oxamate amidohydrolase in the uric acid degradation pathway. Acta Crystallogr D Struct Biol, 72, 2016
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3L9Q
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6XH1
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![BU of 6xh1 by Molmil](/molmil-images/mine/6xh1) | |