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PDB: 33 件
2X9C
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Crystal structure of a soluble PrgI mutant from Salmonella Typhimurium
分子名称: PROTEIN PRGI
著者Poyraz, O, Schmidt, H, Seidel, K, Delissen, F, Ader, C, Tenenboim, H, Goosmann, C, Laube, B, Thuenemann, A.F, Zychlinsky, A, Baldus, M, Lange, A, Griesinger, C, Kolbe, M.
登録日2010-03-15
公開日2010-06-16
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Protein Refolding is Required for Assembly of the Type Three Secretion Needle
Nat.Struct.Mol.Biol., 17, 2010
2KV7
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NMR solution structure of a soluble PrgI mutant from Salmonella Typhimurium
分子名称: Protein prgI
著者Schmidt, H, Poyraz, O, Seidel, K, Delissen, F, Ader, C, Tenenboim, H, Goosmann, C, Laube, B, Thuenemann, A.F, Zychlinski, A, Baldus, M, Lange, A, Griesinger, C, Kolbe, M.
登録日2010-03-09
公開日2010-06-16
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Protein refolding is required for assembly of the type three secretion needle.
Nat.Struct.Mol.Biol., 17, 2010
6OL3
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Crystal structure of an adenovirus virus-associated RNA
分子名称: Adenovirus Virus-Associated (VA) RNA I apical and central domains, POTASSIUM ION
著者Hood, I.V, Gordon, J.M, Bou-Nader, C, Henderson, F.V, Bahmanjah, S, Zhang, J.
登録日2019-04-15
公開日2019-07-03
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.74 Å)
主引用文献Crystal structure of an adenovirus virus-associated RNA.
Nat Commun, 10, 2019
7TQA
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BU of 7tqa by Molmil
Crystal Structure of monoclonal S9.6 Fab
分子名称: Fab S9.6 heavy chain, Fab S9.6 light chain, GLYCEROL, ...
著者Bou-Nader, C, Zhang, J.
登録日2022-01-26
公開日2022-03-30
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.328 Å)
主引用文献Structural basis of R-loop recognition by the S9.6 monoclonal antibody.
Nat Commun, 13, 2022
7TQB
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BU of 7tqb by Molmil
Crystal structure of monoclonal S9.6 Fab bound to DNA-RNA hybrid
分子名称: DNA, FAB S9.6 Heavy Chain, FAB S9.6 Light Chain, ...
著者Bou-Nader, C, Zhang, J.
登録日2022-01-26
公開日2022-03-30
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural basis of R-loop recognition by the S9.6 monoclonal antibody.
Nat Commun, 13, 2022
4WFS
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BU of 4wfs by Molmil
Crystal Structure of tRNA-dihydrouridine(20) synthase catalytic domain
分子名称: CHLORIDE ION, FLAVIN MONONUCLEOTIDE, SULFATE ION, ...
著者Bou-Nader, C, Pecqueur, L, Kamah, A, Bregeon, D, Golinelli-Pimpaneau, B, Guimaraes, B.G, Fontecave, M, Hamdane, D.
登録日2014-09-17
公開日2015-10-07
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献An extended dsRBD is required for post-transcriptional modification in human tRNAs.
Nucleic Acids Res., 43, 2015
4WFT
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BU of 4wft by Molmil
Crystal structure of tRNA-dihydrouridine(20) synthase dsRBD domain
分子名称: tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
著者Bou-Nader, C, Pecqueur, L, Kamah, A, Bregeon, D, Golinelli-Pimpaneau, B, Guimaraes, B.G, Fontecave, M, Hamdane, D.
登録日2014-09-17
公開日2015-10-07
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献An extended dsRBD is required for post-transcriptional modification in human tRNAs.
Nucleic Acids Res., 43, 2015
5OC6
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Crystal structure of human tRNA-dihydrouridine(20) synthase dsRBD in complex with a 22 nucleotide dsRNA
分子名称: RNA, tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
著者Bou-nader, C, Pecqueur, L, Hamdane, D.
登録日2017-06-29
公開日2018-12-26
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Molecular basis for transfer RNA recognition by the double-stranded RNA-binding domain of human dihydrouridine synthase 2.
Nucleic Acids Res., 47, 2019
5OC5
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Crystal structure of human tRNA-dihydrouridine(20) synthase dsRBD K419A-K420A mutant
分子名称: CHLORIDE ION, GLYCEROL, tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
著者Bou-nader, C, Pecqueur, L, Hamdane, D.
登録日2017-06-29
公開日2018-12-26
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.893 Å)
主引用文献Molecular basis for transfer RNA recognition by the double-stranded RNA-binding domain of human dihydrouridine synthase 2.
Nucleic Acids Res., 47, 2019
5NL1
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Shigella IpaA-VBS3/TBS in complex with the Talin VBS1 domain 488-512
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Invasin IpaA, ...
著者Bou-Nader, C, Pecqueur, L, Valencia-Gallardo, C, Fontecave, M, Tran Van Nhieu, G.
登録日2017-04-03
公開日2018-05-16
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Shigella IpaA Binding to Talin Stimulates Filopodial Capture and Cell Adhesion.
Cell Rep, 26, 2019
6EI8
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Crystal structure of human tRNA-dihydrouridine (20) synthase dsRBD F359A mutant
分子名称: SULFATE ION, tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
著者Bou-Nader, C, Pecqueur, L, Hamdane, D.
登録日2017-09-18
公開日2018-10-10
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Conformational Stability Adaptation of a Double-Stranded RNA-Binding Domain to Transfer RNA Ligand.
Biochemistry, 58, 2019
5OC4
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Crystal structure of human tRNA-dihydrouridine(20) synthase dsRBD R361A-R362A mutant
分子名称: CACODYLATE ION, CHLORIDE ION, GLYCEROL, ...
著者Bou-nader, C, Pecqueur, L, Hamdane, D.
登録日2017-06-29
公開日2018-12-26
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Molecular basis for transfer RNA recognition by the double-stranded RNA-binding domain of human dihydrouridine synthase 2.
Nucleic Acids Res., 47, 2019
7NDZ
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ThyX reconstituted with N5-carbinolamine flavin
分子名称: DI(HYDROXYETHYL)ETHER, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, Flavin-dependent thymidylate synthase, ...
著者Bou-Nader, C, Pecqueur, L, Hamdane, D.
登録日2021-02-02
公開日2021-07-21
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献An enzymatic activation of formaldehyde for nucleotide methylation.
Nat Commun, 12, 2021
7NDW
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ThyX-FADH2 soaked with 20 mM Formaldehyde
分子名称: DI(HYDROXYETHYL)ETHER, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, Flavin-dependent thymidylate synthase, ...
著者Bou-Nader, C, Pecqueur, L, Hamdane, D.
登録日2021-02-02
公開日2021-07-21
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献An enzymatic activation of formaldehyde for nucleotide methylation.
Nat Commun, 12, 2021
7TUS
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BU of 7tus by Molmil
Sculpting a uniquely reactive cysteine residue for site-specific antibody conjugation
分子名称: Antibody Heavy Chain, Antibody Light Chain, DI(HYDROXYETHYL)ETHER, ...
著者Park, H, Rader, C.
登録日2022-02-03
公開日2022-06-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Sculpting a Uniquely Reactive Cysteine Residue for Site-Specific Antibody Conjugation.
Bioconjug.Chem., 33, 2022
7MRL
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BU of 7mrl by Molmil
Structure of HIV-1 matrix domain bound to human tRNALys3
分子名称: HIV-1 matrix domain, MAGNESIUM ION, tRNA Lys3
著者Bou-Nader, C, Zhang, J.
登録日2021-05-07
公開日2021-08-11
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献HIV-1 matrix-tRNA complex structure reveals basis for host control of Gag localization.
Cell Host Microbe, 29, 2021
8CIZ
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BU of 8ciz by Molmil
DNA-polymerase sliding clamp (DnaN) from Escherichia coli in complex with Mycoplanecin A.
分子名称: Beta sliding clamp, Mycoplanecin A
著者Fu, C, Liu, Y, Walt, C, Bader, C, Rasheed, S, Lukat, P, Neuber, M, Blankenfeldt, W, Kalinina, O, Mueller, R.
登録日2023-02-11
公開日2023-11-29
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins.
Nat Commun, 15, 2024
6EI9
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BU of 6ei9 by Molmil
Crystal structure of E. coli tRNA-dihydrouridine synthase B (DusB)
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, FLAVIN MONONUCLEOTIDE, GLYCEROL, ...
著者Bou-Nader, C, Hamdane, D.
登録日2017-09-18
公開日2018-01-17
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Unveiling structural and functional divergences of bacterial tRNA dihydrouridine synthases: perspectives on the evolution scenario.
Nucleic Acids Res., 46, 2018
6EZA
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BU of 6eza by Molmil
Crystal Structure of human tRNA-dihydrouridine(20) synthase catalytic domain E294K mutant
分子名称: CHLORIDE ION, FLAVIN MONONUCLEOTIDE, GLYCEROL, ...
著者Bou-Nader, C, Bregeon, D, Pecqueur, L, Vincent, G, Fontecave, M, Hamdane, D.
登録日2017-11-14
公開日2018-09-26
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Electrostatic Potential in the tRNA Binding Evolution of Dihydrouridine Synthases.
Biochemistry, 57, 2018
6EZB
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BU of 6ezb by Molmil
Crystal Structure of human tRNA-dihydrouridine(20) synthase catalytic domain Q305K mutant
分子名称: FLAVIN MONONUCLEOTIDE, GLYCEROL, SULFATE ION, ...
著者Bou-Nader, C, Bregeon, D, Pecqueur, L, Fontecave, M, Hamdane, D.
登録日2017-11-14
公開日2018-09-26
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Electrostatic Potential in the tRNA Binding Evolution of Dihydrouridine Synthases.
Biochemistry, 57, 2018
6EZC
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Crystal Structure of human tRNA-dihydrouridine(20) synthase catalytic domain E294K Q305K double mutant
分子名称: CHLORIDE ION, FLAVIN MONONUCLEOTIDE, GLYCEROL, ...
著者Bou-Nader, C, Bregeon, D, Vincent, G, Fontecave, M, Hamdane, D.
登録日2017-11-14
公開日2018-09-26
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Electrostatic Potential in the tRNA Binding Evolution of Dihydrouridine Synthases.
Biochemistry, 57, 2018
8CIY
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BU of 8ciy by Molmil
DNA-polymerase sliding clamp (DnaN) from Escherichia coli in complex with Cyclohexyl-Griselimycin.
分子名称: ACETATE ION, Beta sliding clamp, CALCIUM ION, ...
著者Fu, C, Liu, Y, Walt, C, Bader, C, Rasheed, S, Lukat, P, Neuber, M, Blankenfeldt, W, Kalinina, O, Mueller, R.
登録日2023-02-11
公開日2023-11-29
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins.
Nat Commun, 15, 2024
8CIX
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BU of 8cix by Molmil
DNA-polymerase sliding clamp (DnaN) from Escherichia coli in complex with Griselimycin.
分子名称: ACETATE ION, Beta sliding clamp, CALCIUM ION, ...
著者Fu, C, Liu, Y, Walt, C, Bader, C, Rasheed, S, Lukat, P, Neuber, M, Blankenfeldt, W, Kalinina, O, Mueller, R.
登録日2023-02-11
公開日2023-11-29
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins.
Nat Commun, 15, 2024
6OSV
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Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2
分子名称: Antibody heavy chain variable region, Antibody light chain variable region, Tyrosine-protein kinase transmembrane receptor ROR2
著者Park, H, Rader, C.
登録日2019-05-02
公開日2020-04-01
最終更新日2020-05-13
実験手法X-RAY DIFFRACTION (1.34 Å)
主引用文献Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications.
J.Biol.Chem., 295, 2020
6OSN
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Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2
分子名称: ACETATE ION, Tyrosine-protein kinase transmembrane receptor ROR2
著者Park, H, Rader, C.
登録日2019-05-01
公開日2020-04-01
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.083 Å)
主引用文献Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications.
J.Biol.Chem., 295, 2020

 

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