8ZP2
 
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9CMU
 | | Room-temperature X-ray structure of SARS-CoV-2 main protease drug resistant mutant (L50F, E166V) in complex with ensitrelvir (ESV) | | Descriptor: | 3C-like proteinase nsp5, 6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione | | Authors: | Kovalevsky, A, Coates, L, Gerlits, O. | | Deposit date: | 2024-07-15 | | Release date: | 2024-10-16 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Effects of SARS-CoV-2 Main Protease Mutations at Positions L50, E166, and L167 Rendering Resistance to Covalent and Noncovalent Inhibitors.
J.Med.Chem., 67, 2024
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9FLR
 | | Crystal structure of human Haspin (GSG2) kinase bound to MU1963 | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 5-(1-methylpyrazol-4-yl)-3-pyridin-4-yl-1~{H}-pyrazolo[1,5-a]pyrimidine, NICKEL (II) ION, ... | | Authors: | Kraemer, A, Paruch, K, Knapp, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2024-06-05 | | Release date: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | Crystal structure of human Haspin (GSG2) kinase bound to MU1959
To Be Published
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9DVG
 | | A DARPin fused to the 1TEL crystallization chaperone via a direct helical fusion | | Descriptor: | Transcription factor ETV6,DARPin | | Authors: | Pedroza Romo, M.J, Averett, J.C, Keliiliki, A, Wilson, E.W, Smith, C, Hansen, D, Averett, B, Gonzalez, J, Noakes, E, Nickles, R, Doukov, T, Moody, J.D. | | Deposit date: | 2024-10-07 | | Release date: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (3.54 Å) | | Cite: | Optimal TELSAM-Target Protein Linker Character is Target Protein Dependent
To Be Published
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9GRP
 | | SARS-CoV-2 methyltransferase nsp10-16 in complex with SAM and beta-chloroethyl theophylline | | Descriptor: | 1,2-ETHANEDIOL, 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | | Authors: | Kremling, V, Sprenger, J, Oberthuer, D, Kiene, A. | | Deposit date: | 2024-09-12 | | Release date: | 2024-09-25 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structures of SARS-CoV-2 methyltransferase nsp10-16 with Cap0-site binders
To Be Published
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9GG1
 | | P301T type I tau filaments from human brain | | Descriptor: | Isoform Tau-D of Microtubule-associated protein tau | | Authors: | Schweighauser, M, Shi, Y, Murzin, A.G, Garringer, H.J, Vidal, R, Murrell, J.R, Erro, M.E, Seelaar, H, Ferrer, I, van Swieten, J.C, Ghetti, B, Scheres, S.H.W, Goedert, M. | | Deposit date: | 2024-08-12 | | Release date: | 2024-09-11 | | Method: | ELECTRON MICROSCOPY (2.26 Å) | | Cite: | Novel tau filament folds in individuals with MAPT mutations P301L and P301T.
Biorxiv, 2024
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9GTF
 | | SARS-CoV-2 methyltransferase nsp10-16 in complex with SAM and theophylline derivative LAS 57256190 | | Descriptor: | 1,2-ETHANEDIOL, 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | | Authors: | Kremling, V, Sprenger, J, Oberthuer, D, Kiene, A. | | Deposit date: | 2024-09-17 | | Release date: | 2024-10-02 | | Method: | X-RAY DIFFRACTION (2.28 Å) | | Cite: | Crystal structures of SARS-CoV-2 methyltransferase nsp10-16 with Cap0-site binders
To Be Published
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9GUF
 | | SARS-CoV-2 methyltransferase nsp10-16 in complex with SAM and theophylline derivative LAS 54571106 | | Descriptor: | 1,2-ETHANEDIOL, 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | | Authors: | Kremling, V, Sprenger, J, Oberthuer, D, Kiene, A. | | Deposit date: | 2024-09-19 | | Release date: | 2024-10-02 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structures of SARS-CoV-2 methyltransferase nsp10-16 with Cap0-site binders
To Be Published
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9B0Z
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8ZOY
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6ZCU
 | | syk in complex with 57262_SYKB-AZ13344324-2 | | Descriptor: | 6-chloro-2-(2-fluoro-4,5-dimethoxyphenyl)-N-(piperidin-4-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-amine, Tyrosine-protein kinase SYK | | Authors: | Read, J.A, Patel, J. | | Deposit date: | 2020-06-12 | | Release date: | 2021-06-23 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.73 Å) | | Cite: | SYK Kinase domain in complex with azabenzimidazole inhibitor 2b
To Be Published
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8QKZ
 | | Human Carbonic Anhydrase II in complex with 3,4-dihydro-1H-benzo[c][1,2]oxaborinin-1-ol at pH 9.0 | | Descriptor: | 1,1-bis(oxidanyl)-3,4-dihydro-2,1$l^{4}-benzoxaborinine, 1,2-ETHANEDIOL, Carbonic anhydrase 2, ... | | Authors: | Angeli, A, Ferraroni, M. | | Deposit date: | 2023-09-18 | | Release date: | 2024-10-02 | | Method: | X-RAY DIFFRACTION (1.34 Å) | | Cite: | Human Carbonic Anhydrase II in complex with 3,4-dihydro-1H-benzo[c][1,2]oxaborinin-1-ol at pH 9.0
To Be Published
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8QUF
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9FLQ
 | | Crystal structure of human Haspin (GSG2) kinase bound to MU1959 | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, NICKEL (II) ION, ... | | Authors: | Kraemer, A, Paruch, K, Knapp, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2024-06-05 | | Release date: | 2024-09-11 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Crystal structure of human Haspin (GSG2) kinase bound to MU1959
To Be Published
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6ZCR
 | | SYK Kinase domain in complex with azabenzimidazole inhibitor 7 | | Descriptor: | 6-chloro-2-(2-fluoro-4,5-dimethoxyphenyl)-N-(piperidin-4-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-amine, Tyrosine-protein kinase SYK | | Authors: | Read, J.A, Patel, J. | | Deposit date: | 2020-06-12 | | Release date: | 2021-06-23 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.73 Å) | | Cite: | SYK Kinase domain in complex with azabenzimidazole inhibitor 7
To Be Published
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7KNK
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9PTI
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8ZPB
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9GG0
 | | P301L tau filaments from human brain | | Descriptor: | Isoform Tau-D of Microtubule-associated protein tau | | Authors: | Schweighauser, M, Shi, Y, Murzin, A.G, Garringer, H.J, Vidal, R, Murrell, J.R, Erro, M.E, Seelaar, H, Ferrer, I, van Swieten, J.C, Ghetti, B, Scheres, S.H.W, Goedert, M. | | Deposit date: | 2024-08-12 | | Release date: | 2024-09-11 | | Method: | ELECTRON MICROSCOPY (2.81 Å) | | Cite: | Novel tau filament folds in individuals with MAPT mutations P301L and P301T.
Biorxiv, 2024
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9C8S
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8EP6
 | | Crystal Structure of the Beta-lactamase Class D from Chitinophaga pinensis in complex with Avibactam | | Descriptor: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, ACETIC ACID, Beta-lactamase Class D Cpin_0907 | | Authors: | Maltseva, N, Kim, Y, Endres, M, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID) | | Deposit date: | 2022-10-05 | | Release date: | 2022-10-19 | | Last modified: | 2023-02-01 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Crystal Structure of the Beta-lactamase Class D from Chitinophaga pinensis in the complex with Avibactam.
To Be Published
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8YMK
 | | Localized reconstruction of Hepatitis B virus surface antigen dimer in the subviral particle with D2 symmetry from dataset A0 | | Descriptor: | Isoform S of Large envelope protein | | Authors: | Wang, T, Cao, L, Mu, A, Wang, Q, Rao, Z.H. | | Deposit date: | 2024-03-09 | | Release date: | 2024-09-18 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Inherent symmetry and flexibility in hepatitis B virus subviral particles.
Science, 385, 2024
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9AVT
 | | Structure of TAB2 NZF domain bound to K6 / Lys6-linked diubiquitin | | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, SULFATE ION, TGF-beta-activated kinase 1 and MAP3K7-binding protein 2, ... | | Authors: | Michel, M.A, Scutts, S, Komander, D. | | Deposit date: | 2024-03-04 | | Release date: | 2024-07-31 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structure of TAB2 NZF domain bound to K6 / Lys6-linked diubiquitin
To be published
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9GUE
 | | SARS-CoV-2 methyltransferase nsp10-16 in complex with SAM and theophylline derivative LAS 57256189 | | Descriptor: | 1,2-ETHANEDIOL, 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | | Authors: | Kremling, V, Sprenger, J, Oberthuer, D, Kiene, A. | | Deposit date: | 2024-09-19 | | Release date: | 2024-10-02 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Crystal structures of SARS-CoV-2 methyltransferase nsp10-16 with Cap0-site binders
To Be Published
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9GNY
 | | SARS-CoV-2 methyltransferase nsp10-16 in complex with SAM and Caffeine | | Descriptor: | 1,2-ETHANEDIOL, 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | | Authors: | Kremling, V, Sprenger, J, Oberthuer, D, Kiene, A. | | Deposit date: | 2024-09-04 | | Release date: | 2024-09-25 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structures of SARS-CoV-2 methyltransferase nsp10-16 with Cap0-site binders
to be published
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