8ZOY

Cryo-EM structure of human norepinephrine transporter NET bound with norepinephrine in an inward open state at a resolution of 2.5 angstrom

Summary for 8ZOY

• Entry DOI: 10.2210/pdb8zoy/pdb
• Related: 8ZP1 8ZP2
• EMDB information: 60322 60324 60325
• Descriptor: Sodium-dependent noradrenaline transporter, Nb_BF9, L-NOREPINEPHRINE, ... (6 entities in total)
• Functional Keywords: norepinephrine transport, norepinephrine, transport protein/immune system, transport protein-immune system complex
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 78634.06

Authors

Song, A.L.,Wu, X.D. (deposition date: 2024-05-29, release date: 2024-09-11, Last modification date: 2025-07-23)

• Primary citation: Song, A.,Wu, X.; Mechanistic insights of substrate transport and inhibitor binding revealed by high-resolution structures of human norepinephrine transporter.; Cell Res., 34:810-813, 2024; PubMed: 39223283; DOI: 10.1038/s41422-024-01024-0

Experimental method

ELECTRON MICROSCOPY (2.5 Å)