6O4K
 
 | | Structure of ALDH7A1 mutant E399Q complexed with NAD | | Descriptor: | 1,2-ETHANEDIOL, Alpha-aminoadipic semialdehyde dehydrogenase, CHLORIDE ION, ... | | Authors: | Tanner, J.J, Korasick, D.A, Laciak, A.R. | | Deposit date: | 2019-02-28 | | Release date: | 2019-11-06 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | Structural analysis of pathogenic mutations targeting Glu427 of ALDH7A1, the hot spot residue of pyridoxine-dependent epilepsy.
J. Inherit. Metab. Dis., 43, 2020
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9C8S
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6OQR
 | | E. coli ATP Synthase ADP State 1a | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... | | Authors: | Stewart, A.G, Walshe, J.L, Sobti, M. | | Deposit date: | 2019-04-29 | | Release date: | 2020-06-03 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Cryo-EM structures provide insight into how E. coli F1FoATP synthase accommodates symmetry mismatch.
Nat Commun, 11, 2020
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8WO0
 | | CryoEM structure of ZIKV rsNS1 filament | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Non-structural protein 1 | | Authors: | Chew, B.L.A, Luo, D. | | Deposit date: | 2023-10-06 | | Release date: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (8 Å) | | Cite: | Structural basis of Zika virus NS1 multimerization and human antibody recognition
Npj Viruses, 2, 2024
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5LE2
 | | Crystal structure of DARPin-DARPin rigid fusion, variant DDD_D12_15_D12_15_D12 | | Descriptor: | ACETATE ION, DDD_D12_15_D12_15_D12, THIOCYANATE ION | | Authors: | Batyuk, A, Wu, Y, Mittl, P.R, Plueckthun, A. | | Deposit date: | 2016-06-29 | | Release date: | 2017-08-02 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Rigidly connected multispecific artificial binders with adjustable geometries.
Sci Rep, 7, 2017
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8WN8
 | | CryoEM structure of ZIKV rsNS1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Non-structural protein 1 | | Authors: | Chew, B.L.A, Luo, D. | | Deposit date: | 2023-10-05 | | Release date: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural basis of Zika virus NS1 multimerization and human antibody recognition
Npj Viruses, 2, 2024
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5LEC
 | | Crystal structure of DARPin-DARPin rigid fusion, variant DDD_D12_12_D12_12_D12 | | Descriptor: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DDD_D12_12_D12_12_D12 | | Authors: | Batyuk, A, Wu, Y, Mittl, P.R, Plueckthun, A. | | Deposit date: | 2016-06-29 | | Release date: | 2017-08-02 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.506 Å) | | Cite: | Rigidly connected multispecific artificial binders with adjustable geometries.
Sci Rep, 7, 2017
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5LEL
 | | Crystal structure of DARPin-DARPin rigid fusion, variant DD_Off7_10_3G124 in complex with Maltose-binding Protein and Green Fluorescent Protein | | Descriptor: | DD_Off7_10_3G124, Green fluorescent protein, Maltose-binding periplasmic protein | | Authors: | Batyuk, A, Wu, Y, Mittl, P.R, Plueckthun, A. | | Deposit date: | 2016-06-30 | | Release date: | 2017-11-15 | | Last modified: | 2019-10-16 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Rigidly connected multispecific artificial binders with adjustable geometries.
Sci Rep, 7, 2017
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6OR7
 | | Structure of HIV-1 Reverse Transcriptase (RT) in complex with DNA AND (-)FTC-TP | | Descriptor: | DNA Primer 20-mer, DNA template 27-mer, MAGNESIUM ION, ... | | Authors: | Bertoletti, N, Chan, A.H, Anderson, K.S. | | Deposit date: | 2019-04-29 | | Release date: | 2019-07-24 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.53 Å) | | Cite: | Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV-1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine.
Protein Sci., 28, 2019
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8OM1
 | | Mitochondrial complex I from Mus musculus in the active state | | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Grba, D.N, Chung, I, Bridges, H.R, Agip, A.N.A, Hirst, J. | | Deposit date: | 2023-03-31 | | Release date: | 2023-08-09 | | Last modified: | 2023-08-16 | | Method: | ELECTRON MICROSCOPY (2.39 Å) | | Cite: | Investigation of hydrated channels and proton pathways in a high-resolution cryo-EM structure of mammalian complex I.
Sci Adv, 9, 2023
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7OMK
 | | The NMR structure of the Zf-GRF domains from the mouse Endonuclease VIII-LIKE 3 (mNEIL3) | | Descriptor: | Endonuclease 8-like 3 | | Authors: | Dinesh, D.C, Huskova, A, Srb, P, Veverka, V, Silhan, J. | | Deposit date: | 2021-05-24 | | Release date: | 2022-06-01 | | Last modified: | 2024-06-19 | | Method: | SOLUTION NMR | | Cite: | Model of abasic site DNA cross-link repair; from the architecture of NEIL3 DNA binding domains to the X-structure model.
Nucleic Acids Res., 50, 2022
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5LFT
 | | Crystal structure of cytochrome c - Bromo-trisulfonatocalix[4]arene complexes | | Descriptor: | BROMIDE ION, Bromo-trisulfonatocalix[4]arene, Cytochrome c iso-1, ... | | Authors: | Doolan, A.M, Rennie, M.L, Crowley, P.B. | | Deposit date: | 2016-07-04 | | Release date: | 2017-07-12 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.249 Å) | | Cite: | Protein Recognition by Functionalized Sulfonatocalix[4]arenes.
Chemistry, 24, 2018
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6X8M
 | | CryoEM structure of the holo-SrpI encapsulin complex from Synechococcus elongatus PCC 7942 | | Descriptor: | Protein SrpI | | Authors: | LaFrance, B.J, Nichols, R.J, Phillips, N.R, Oltrogge, L.M, Valentin-Alvarado, L.E, Bischoff, A.J, Savage, D.F, Nogales, E. | | Deposit date: | 2020-06-01 | | Release date: | 2020-06-10 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (2.2 Å) | | Cite: | Discovery and characterization of a novel family of prokaryotic nanocompartments involved in sulfur metabolism.
Elife, 10, 2021
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9CV0
 | | Bufavirus 1 at pH 7.4 | | Descriptor: | VP1 | | Authors: | Gulkis, M.C, McKenna, R, Bennett, A.D. | | Deposit date: | 2024-07-27 | | Release date: | 2024-08-28 | | Method: | ELECTRON MICROSCOPY (2.84 Å) | | Cite: | Structural Characterization of Human Bufavirus 1: Receptor Binding and Endosomal pH-Induced Changes
Viruses, 16, 2024
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7N89
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7P2O
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6UMC
 | | Crystal structure of human GAC in complex with inhibitor UPGL00012 | | Descriptor: | 2-phenyl-N-{5-[(3R)-3-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}oxy)pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide, Glutaminase kidney isoform, mitochondrial | | Authors: | Huang, Q, Cerione, R.A. | | Deposit date: | 2019-10-09 | | Release date: | 2020-10-14 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Crystal structure of human GAC in complex with inhibitor UPGL00012
To Be Published
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5LCC
 | | Oceanobacillus iheyensis macrodomain mutant D40A | | Descriptor: | MACROD-TYPE MACRODOMAIN | | Authors: | Gil-Ortiz, F, Zapata-Perez, R, Martinez, A.B, Juanhuix, J, Sanchez-Ferrer, A. | | Deposit date: | 2016-06-20 | | Release date: | 2017-05-03 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural and functional analysis of Oceanobacillus iheyensis macrodomain reveals a network of waters involved in substrate binding and catalysis.
Open Biol, 7, 2017
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6O8K
 | | Crystal Structure of apo and reduced Sulfide-responsive transcriptional repressor (SqrR) from Rhodobacter capsulatus. | | Descriptor: | GLYCEROL, SULFATE ION, Transcriptional regulator, ... | | Authors: | Capdevila, D.A, Gonzalez-Gutierrez, G, Giedroc, D.P. | | Deposit date: | 2019-03-11 | | Release date: | 2020-04-01 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.12 Å) | | Cite: | Structural basis for persulfide-sensing specificity in a transcriptional regulator.
Nat.Chem.Biol., 17, 2021
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7A5Z
 | | Structure of VIM-2 metallo-beta-lactamase with hydrolysed Faropenem imine product | | Descriptor: | (5~{Z})-2-[1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-5-(4-oxidanylbutylidene)-2~{H}-1,3-thiazole-4-carboxylic acid, Beta-lactamase VIM-2, CHLORIDE ION, ... | | Authors: | Lucic, A, Schofield, C.J. | | Deposit date: | 2020-08-24 | | Release date: | 2021-02-24 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.29 Å) | | Cite: | Faropenem reacts with serine and metallo-beta-lactamases to give multiple products.
Eur.J.Med.Chem., 215, 2021
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6OT4
 | | Bimetallic dodecameric cage design 2 (BMC2) from cytochrome cb562 | | Descriptor: | ACETOHYDROXAMIC ACID, FE (III) ION, HEME C, ... | | Authors: | Golub, E, Esselborn, J, Bailey, J.B, Tezcan, F.A. | | Deposit date: | 2019-05-02 | | Release date: | 2020-01-29 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Constructing protein polyhedra via orthogonal chemical interactions.
Nature, 578, 2020
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6RFN
 | | Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-1018 | | Descriptor: | 3-[5-[(4~{a}~{R},8~{a}~{S})-4-oxidanylidene-3-propan-2-yl-4~{a},5,8,8~{a}-tetrahydrophthalazin-1-yl]-2-methoxy-phenyl]-~{N}-(3-methoxyphenyl)prop-2-ynamide, FORMIC ACID, GLYCEROL, ... | | Authors: | Singh, A.K, Brown, D.G. | | Deposit date: | 2019-04-15 | | Release date: | 2019-07-24 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.29 Å) | | Cite: | Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2).
Bioorg.Med.Chem., 27, 2019
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5LHC
 | | The structure of D456A mutant of Nt.BspD6I nicking endonuclease at 0.24 nm resolution . | | Descriptor: | GLYCEROL, Nicking endonuclease N.BspD6I, PHOSPHATE ION | | Authors: | Kachalova, G.S, Yunusova, A.K, Popov, A.N, Artyukh, R.I, Perevyazova, T.A, Bartunik, H.D, Zheleznaya, L.A. | | Deposit date: | 2016-07-10 | | Release date: | 2017-08-16 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural implication of activity loss by D456A mutant of the nicking endonuclease Nt.BspD6I.
To Be Published
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6TVF
 | | Crystal structure of the haemagglutinin from a H10N7 seal influenza virus isolated in Germany in complex with human receptor analogue, 6'-SLN | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Zhang, J, Xiong, X, Purkiss, A, Walker, P, Gamblin, S, Skehel, J.J. | | Deposit date: | 2020-01-09 | | Release date: | 2020-10-21 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Hemagglutinin Traits Determine Transmission of Avian A/H10N7 Influenza Virus between Mammals.
Cell Host Microbe, 28, 2020
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9BIY
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