8DE7
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![BU of 8de7 by Molmil](/molmil-images/mine/8de7) | Cryo-EM structure of the zebrafish two pore domain K+ channel TREK1 (K2P2.1) in DDM detergent | Descriptor: | DODECYL-BETA-D-MALTOSIDE, POTASSIUM ION, Potassium channel, ... | Authors: | Schmidpeter, P.A.M, Nimigean, C.M, Riegelhaupt, P.M. | Deposit date: | 2022-06-20 | Release date: | 2023-03-08 | Method: | ELECTRON MICROSCOPY (3.27 Å) | Cite: | Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1. Nat Commun, 14, 2023
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6ZYY
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![BU of 6zyy by Molmil](/molmil-images/mine/6zyy) | Outer Dynein Arm-Shulin complex - Dyh3 motor region (Tetrahymena thermophila) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Dynein heavy chain, ... | Authors: | Mali, G.R, Abid Ali, F, Lau, C.K, Begum, F, Boulanger, J, Howe, J.D, Chen, Z.A, Rappsilber, J, Skehel, M, Carter, A.P. | Deposit date: | 2020-08-03 | Release date: | 2021-02-03 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Shulin packages axonemal outer dynein arms for ciliary targeting. Science, 371, 2021
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5N3F
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7S1R
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![BU of 7s1r by Molmil](/molmil-images/mine/7s1r) | PRMT5/MEP50 crystal structure with MTA and a phthalazinone inhibitor bound (compound (M)-31) | Descriptor: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein 50, Protein arginine N-methyltransferase 5, ... | Authors: | Gunn, R.J, Thomas, N.C, Lawson, J.D, Ivetac, A, Kulyk, S, Smith, C.R, Marx, M.A. | Deposit date: | 2021-09-02 | Release date: | 2022-01-26 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP -Deleted Cancers. J.Med.Chem., 65, 2022
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6XHO
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![BU of 6xho by Molmil](/molmil-images/mine/6xho) | Covalent complex of SARS-CoV main protease with ethyl (4R)-4-({N-[(4-methoxy-1H-indol-2-yl)carbonyl]-L-leucyl}amino)-5-[(3S)-2-oxopyrrolidin-3-yl]pentanoate | Descriptor: | 1,2-ETHANEDIOL, 3C-like proteinase, ethyl (2E,4S)-4-{[N-(4-methoxy-1H-indole-2-carbonyl)-L-leucyl]amino}-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate | Authors: | Gajiwala, K.S, Ferre, R.A, Ryan, K, Stewart, A.E. | Deposit date: | 2020-06-19 | Release date: | 2020-07-08 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.446 Å) | Cite: | Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19. J.Med.Chem., 63, 2020
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6W7Z
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![BU of 6w7z by Molmil](/molmil-images/mine/6w7z) | RNF12 RING domain in complex with Ube2d2 | Descriptor: | E3 ubiquitin-protein ligase RLIM, GLYCEROL, Ubiquitin-conjugating enzyme E2 D2, ... | Authors: | Middleton, A.J, Day, C.L. | Deposit date: | 2020-03-19 | Release date: | 2020-05-20 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The RING Domain of RING Finger 12 Efficiently Builds Degradative Ubiquitin Chains. J.Mol.Biol., 432, 2020
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6O19
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![BU of 6o19 by Molmil](/molmil-images/mine/6o19) | Crystal Structure of Pho7 complex with pho1 promoter site 2 | Descriptor: | DNA (5'-D(*GP*TP*TP*TP*TP*TP*AP*AP*TP*TP*TP*CP*CP*GP*AP*AP*TP*AP*AP*T)-3'), DNA (5'-D(*TP*TP*AP*TP*TP*CP*GP*GP*AP*AP*AP*TP*TP*AP*AP*AP*AP*AP*CP*A)-3'), Transcription factor Pho7, ... | Authors: | Garg, A, Goldgur, Y, Shuman, S. | Deposit date: | 2019-02-18 | Release date: | 2019-04-24 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.596 Å) | Cite: | Structure of Fission Yeast Transcription Factor Pho7 Bound topho1Promoter DNA and Effect of Pho7 Mutations on DNA Binding and Phosphate Homeostasis. Mol.Cell.Biol., 39, 2019
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8DCN
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![BU of 8dcn by Molmil](/molmil-images/mine/8dcn) | |
5NQN
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7OGT
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![BU of 7ogt by Molmil](/molmil-images/mine/7ogt) | Folded elbow of cohesin | Descriptor: | Structural maintenance of chromosomes protein 1, Structural maintenance of chromosomes protein 3 | Authors: | Lee, B.-G, Gonzalez Llamazares, A, Collier, J, Patele, N.J, Nasmyth, K.A, Lowe, J. | Deposit date: | 2021-05-07 | Release date: | 2021-07-28 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (5.5 Å) | Cite: | Folding of cohesin's coiled coil is important for Scc2/4-induced association with chromosomes. Elife, 10, 2021
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7A6B
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![BU of 7a6b by Molmil](/molmil-images/mine/7a6b) | 1.33 A structure of human apoferritin obtained from Titan Mono- BCOR microscope | Descriptor: | Ferritin heavy chain, SODIUM ION | Authors: | Yip, K.M, Fischer, N, Chari, A, Stark, H. | Deposit date: | 2020-08-25 | Release date: | 2020-09-02 | Last modified: | 2021-02-10 | Method: | ELECTRON MICROSCOPY (1.33 Å) | Cite: | Atomic-resolution protein structure determination by cryo-EM. Nature, 587, 2020
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5N4S
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![BU of 5n4s by Molmil](/molmil-images/mine/5n4s) | VIM-2 metallo-beta-lactamase in complex with ((S)-3-mercapto-2-methylpropanoyl)-D-tryptophan (Compound 3) | Descriptor: | (2~{R})-3-(1~{H}-indol-3-yl)-2-[[(2~{S})-2-methyl-3-sulfanyl-propanoyl]amino]propanoic acid, Beta-lactamase VIM-2, FORMIC ACID, ... | Authors: | Li, G.-B, Brem, J, McDonough, M.A, Schofield, C.J. | Deposit date: | 2017-02-11 | Release date: | 2017-05-17 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Crystallographic analyses of isoquinoline complexes reveal a new mode of metallo-beta-lactamase inhibition. Chem. Commun. (Camb.), 53, 2017
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5N58
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![BU of 5n58 by Molmil](/molmil-images/mine/5n58) | di-Zinc VIM-5 metallo-beta-lactamase in complex with (1-chloro-4-hydroxyisoquinoline-3-carbonyl)-D-tryptophan (Compound 1) | Descriptor: | (2~{R})-2-[(1-chloranyl-4-oxidanyl-isoquinolin-3-yl)carbonylamino]-3-(1~{H}-indol-3-yl)propanoic acid, Class B metallo-beta-lactamase, GLYCEROL, ... | Authors: | Li, G.-B, Brem, J, McDonough, M.A, Schofield, C.J. | Deposit date: | 2017-02-13 | Release date: | 2017-05-17 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.957 Å) | Cite: | Crystallographic analyses of isoquinoline complexes reveal a new mode of metallo-beta-lactamase inhibition. Chem. Commun. (Camb.), 53, 2017
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6XEZ
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![BU of 6xez by Molmil](/molmil-images/mine/6xez) | Structure of SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... | Authors: | Chen, J, Malone, B, Llewellyn, E.C, Campbell, E.A, Darst, S.A. | Deposit date: | 2020-06-14 | Release date: | 2020-07-29 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex. Cell, 182, 2020
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6PU5
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![BU of 6pu5 by Molmil](/molmil-images/mine/6pu5) | MicroED structure of proteinase K recorded on CetaD | Descriptor: | CALCIUM ION, Proteinase K | Authors: | Hattne, J, Martynowycz, M.W, Penzcek, P.A, Gonen, T. | Deposit date: | 2019-07-17 | Release date: | 2019-08-28 | Last modified: | 2023-10-11 | Method: | ELECTRON CRYSTALLOGRAPHY (2.7 Å) | Cite: | MicroED with the Falcon III direct electron detector. Iucrj, 6, 2019
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6ZYK
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![BU of 6zyk by Molmil](/molmil-images/mine/6zyk) | Non-heme monooxygenase, ThoJ-Ni complex | Descriptor: | L(+)-TARTARIC ACID, Monooxygenase, NICKEL (II) ION | Authors: | Koehnke, J, Sikandar, A. | Deposit date: | 2020-08-02 | Release date: | 2020-10-14 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Non-Heme Monooxygenase ThoJ Catalyzes Thioholgamide beta-Hydroxylation. Acs Chem.Biol., 15, 2020
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6ZZP
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![BU of 6zzp by Molmil](/molmil-images/mine/6zzp) | Crystal structure of (R)-3-hydroxybutyrate dehydrogenase from Psychrobacter arcticus complexed with NAD+ and 3-oxovalerate | Descriptor: | 3-oxidanylidenepentanoic acid, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Putative beta-hydroxybutyrate dehydrogenase | Authors: | Machado, T.F.G, da Silva, R.G, Gloster, T.M, McMahon, S.A, Oehler, V. | Deposit date: | 2020-08-04 | Release date: | 2020-10-07 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Dissecting the Mechanism of ( R )-3-Hydroxybutyrate Dehydrogenase by Kinetic Isotope Effects, Protein Crystallography, and Computational Chemistry. Acs Catalysis, 10, 2020
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8EOZ
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![BU of 8eoz by Molmil](/molmil-images/mine/8eoz) | |
4WHA
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![BU of 4wha by Molmil](/molmil-images/mine/4wha) | Lipoxygenase-1 (soybean) L546A/L754A mutant | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, FE (III) ION, ... | Authors: | Scouras, A.D, Carr, C.A.M, Hu, S, Klinman, J.P. | Deposit date: | 2014-09-21 | Release date: | 2014-11-12 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Extremely elevated room-temperature kinetic isotope effects quantify the critical role of barrier width in enzymatic C-H activation. J.Am.Chem.Soc., 136, 2014
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7O0A
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![BU of 7o0a by Molmil](/molmil-images/mine/7o0a) | Bdellovibrio bacteriovorus PGI in P1211 spacegroup | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Glucose-6-phosphate isomerase | Authors: | Meek, R.W, Lovering, A.L. | Deposit date: | 2021-03-26 | Release date: | 2021-08-18 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | Bdellovibrio bacteriovorus phosphoglucose isomerase structures reveal novel rigidity in the active site of a selected subset of enzymes upon substrate binding. Open Biology, 11, 2021
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6XSJ
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![BU of 6xsj by Molmil](/molmil-images/mine/6xsj) | |
7NSS
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![BU of 7nss by Molmil](/molmil-images/mine/7nss) | Bdellovibrio bacteriovorus PGI in P3121 spacegroup | Descriptor: | 1,2-ETHANEDIOL, Glucose-6-phosphate isomerase | Authors: | Meek, R.W, Lovering, A.L. | Deposit date: | 2021-03-08 | Release date: | 2021-08-18 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Bdellovibrio bacteriovorus phosphoglucose isomerase structures reveal novel rigidity in the active site of a selected subset of enzymes upon substrate binding. Open Biology, 11, 2021
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6XTE
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![BU of 6xte by Molmil](/molmil-images/mine/6xte) | Human karyopherin RanBP5 (isoform-1) | Descriptor: | Antipain, CHLORIDE ION, Importin-5, ... | Authors: | Swale, C, McCarthy, A.A, Ruigrok, R.W.H, Crepin, T. | Deposit date: | 2020-01-16 | Release date: | 2020-04-22 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | X-ray Structure of the Human Karyopherin RanBP5, an Essential Factor for Influenza Polymerase Nuclear Trafficking. J.Mol.Biol., 432, 2020
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5N2L
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![BU of 5n2l by Molmil](/molmil-images/mine/5n2l) | Crystal structure of the second bromodomain of human BRD2 in complex with a tetrahydroquinoline analogue | Descriptor: | 1,2-ETHANEDIOL, Bromodomain-containing protein 2, SULFATE ION, ... | Authors: | Tallant, C, Slavish, P.J, Siejka, P, Bharatham, N, Shadrick, W.R, Chai, S, Young, B.M, Boyd, V.A, Heroven, C, Wiggers, H.J, Picaud, S, Fedorov, O, Krojer, T, Chen, T, Lee, R.E, Guy, R.K, Shelat, A.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2017-02-07 | Release date: | 2018-02-28 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Crystal structure of the second bromodomain of human BRD2 in complex with a tetrahydroquinoline analogue To Be Published
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8D9D
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![BU of 8d9d by Molmil](/molmil-images/mine/8d9d) | Human DNA polymerase-alpha/primase elongation complex II bound to primer/template | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*TP*GP*GP*TP*CP*GP*TP*GP*CP*CP*GP*CP*CP*AP*AP*TP*AP*A)-3'), DNA polymerase alpha catalytic subunit, ... | Authors: | He, Q, Baranovskiy, A, Lim, C, Tahirov, T. | Deposit date: | 2022-06-09 | Release date: | 2023-04-19 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.59 Å) | Cite: | Structures of human primosome elongation complexes. Nat.Struct.Mol.Biol., 30, 2023
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