7LWA
 
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8ENI
 | | Crystal structure of Staphylococcus aureus biotin protein ligase in complex with inhibitor | | Descriptor: | 3-[4-(5-fluoro-4-{5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentyl}-1H-1,2,3-triazol-1-yl)butyl]-5-methyl-1,3-benzoxazol-2(3H)-one, Bifunctional ligase/repressor BirA | | Authors: | Wilce, M.C.J, Cini, D.A. | | Deposit date: | 2022-09-30 | | Release date: | 2022-11-30 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Halogenation of Biotin Protein Ligase Inhibitors Improves Whole Cell Activity against Staphylococcus aureus.
ACS Infect Dis, 4, 2018
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3HLT
 | | The crystal structure of human haloacid dehalogenase-like hydrolase domain containing 2 (HDHD2) | | Descriptor: | CHLORIDE ION, HDHD2, SODIUM ION, ... | | Authors: | Ugochukwu, E, Shafqat, N, Yue, W.W, Cocking, R, Bray, J.E, Muniz, J.R.C, Krojer, T, von Delft, F, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Oppermann, U, Structural Genomics Consortium (SGC) | | Deposit date: | 2009-05-28 | | Release date: | 2009-07-07 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The crystal structure of human haloacid dehalogenase-like hydrolase domain containing 2 (HDHD2)
To be Published
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7Z6M
 | | Crystal structure of Zn2+-transporter BbZIP in a cadmium bound state | | Descriptor: | CADMIUM ION, Putative membrane protein | | Authors: | Wiuf, A, Steffen, J.H, Becares, E.R, Groenberg, C, Mahato, D.R, Rasmussen, S.G.F, Andersson, M, Croll, T, Gotfryd, K, Gourdon, P. | | Deposit date: | 2022-03-13 | | Release date: | 2022-08-10 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | The two-domain elevator-type mechanism of zinc-transporting ZIP proteins.
Sci Adv, 8, 2022
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6YJD
 | | Lamin A coil2 dimer stabilized by N-terminal capping | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, Capsid assembly scaffolding protein,Prelamin-A/C, ... | | Authors: | Lilina, A.V, Stalmans, G, Strelkov, S.V. | | Deposit date: | 2020-04-03 | | Release date: | 2021-02-24 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Addressing the Molecular Mechanism of Longitudinal Lamin Assembly Using Chimeric Fusions.
Cells, 9, 2020
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6PJJ
 | | Human PRPF4B bound to benzothiophene inhibitor 224 | | Descriptor: | 1,2-ETHANEDIOL, 4-(5-{[(3-aminophenyl)methyl]carbamoyl}thiophen-2-yl)-1-benzothiophene-2-carboxamide, PHOSPHATE ION, ... | | Authors: | Godoi, P.H.C, Santiago, A.S, Fala, A.M, Ramos, P.Z, Sriranganadane, D, Mascarello, A, Segretti, N, Azevedo, H, Guimaraes, C.R.W, Arruda, P, Elkins, J.M, Counago, R.M, Structural Genomics Consortium (SGC) | | Deposit date: | 2019-06-28 | | Release date: | 2019-08-28 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | to be published
To Be Published
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6UCK
 | | proIAPP in DPC Micelles - Two-Conformer Ensemble Refinement, Bent Conformer | | Descriptor: | Islet amyloid polypeptide | | Authors: | DeLisle, C.F, Malooley, A.L, Banerjee, I, Lorieau, J.L. | | Deposit date: | 2019-09-16 | | Release date: | 2020-02-26 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Pro-islet amyloid polypeptide in micelles contains a helical prohormone segment.
Febs J., 287, 2020
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6XEO
 | | Structure of Mfd bound to dsDNA | | Descriptor: | DNA (5'-D(P*AP*GP*GP*AP*TP*AP*CP*TP*TP*AP*CP*AP*GP*CP*CP*AP*TP*C)-3'), DNA (5'-D(P*GP*AP*TP*GP*GP*CP*TP*GP*TP*AP*AP*GP*TP*AP*TP*CP*CP*T)-3'), Transcription-repair-coupling factor | | Authors: | Brugger, C, Deaconescu, A. | | Deposit date: | 2020-06-12 | | Release date: | 2020-08-19 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (5.5 Å) | | Cite: | Molecular determinants for dsDNA translocation by the transcription-repair coupling and evolvability factor Mfd.
Nat Commun, 11, 2020
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6UCJ
 | | proIAPP in DPC Micelles - Two-Conformer Ensemble Refinement, Open Conformer | | Descriptor: | Islet amyloid polypeptide | | Authors: | DeLisle, C.F, Malooley, A.L, Banerjee, I, Lorieau, J.L. | | Deposit date: | 2019-09-16 | | Release date: | 2020-02-26 | | Last modified: | 2024-10-30 | | Method: | SOLUTION NMR | | Cite: | Pro-islet amyloid polypeptide in micelles contains a helical prohormone segment.
Febs J., 287, 2020
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4WF4
 | | Crystal structure of E.Coli DsbA co-crystallised in complex with compound 4 | | Descriptor: | 1,2-ETHANEDIOL, 4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylic acid, Thiol:disulfide interchange protein | | Authors: | Adams, L.A, Sharma, P, Mohanty, B, Ilyichova, O.V, Mulcair, M.D, Williams, M.L, Gleeson, E.C, Totsika, M, Doak, B.C, Caria, S, Rimmer, K, Shouldice, S.R, Vazirani, M, Headey, S.J, Plumb, B.R, Martin, J.L, Heras, B, Simpson, J.S, Scanlon, M.J. | | Deposit date: | 2014-09-12 | | Release date: | 2015-01-21 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Application of Fragment-Based Screening to the Design of Inhibitors of Escherichia coli DsbA.
Angew.Chem.Int.Ed.Engl., 54, 2015
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8RGE
 | | Serial synchrotron in plate room temperature structure of Lysozyme. | | Descriptor: | CHLORIDE ION, Lysozyme C, SODIUM ION | | Authors: | Thompson, A.J, Hough, M.A, Sanchez-Weatherby, J, Williams, L.J, Sandy, J, Worrall, J.A.R. | | Deposit date: | 2023-12-13 | | Release date: | 2023-12-27 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | Efficient in situ screening of and data collection from microcrystals in crystallization plates.
Acta Crystallogr D Struct Biol, 80, 2024
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6QVL
 | | Human SHMT2 in complex with pemetrexed | | Descriptor: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | Authors: | Scaletti, E, Jemth, A.S, Helleday, T, Stenmark, P. | | Deposit date: | 2019-03-03 | | Release date: | 2019-09-04 | | Method: | X-RAY DIFFRACTION (2.28 Å) | | Cite: | Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs.
Febs Lett., 593, 2019
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6G2I
 | | Filament of acetyl-CoA carboxylase and BRCT domains of BRCA1 (ACC-BRCT) at 5.9 A resolution | | Descriptor: | Acetyl-CoA carboxylase 1, Breast cancer type 1 susceptibility protein | | Authors: | Hunkeler, M, Hagmann, A, Stuttfeld, E, Chami, M, Stahlberg, H, Maier, T. | | Deposit date: | 2018-03-23 | | Release date: | 2018-06-13 | | Last modified: | 2019-12-11 | | Method: | ELECTRON MICROSCOPY (5.9 Å) | | Cite: | Structural basis for regulation of human acetyl-CoA carboxylase.
Nature, 558, 2018
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6PNU
 | | Crystal structure of native DauA | | Descriptor: | 1,2-ETHANEDIOL, Aldehyde dehydrogenase | | Authors: | Pluvinage, B, Boraston, A.B. | | Deposit date: | 2019-07-03 | | Release date: | 2019-10-02 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Insights into the kappa / iota-carrageenan metabolism pathway of some marinePseudoalteromonasspecies.
Commun Biol, 2, 2019
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7LW7
 | | Human Exonuclease 5 crystal structure | | Descriptor: | 1,2-ETHANEDIOL, Exonuclease V, GLYCEROL, ... | | Authors: | Tsai, C.L, Tainer, J.A. | | Deposit date: | 2021-02-27 | | Release date: | 2021-07-14 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart.
Mol.Cell, 81, 2021
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8R8C
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5M5J
 | | Thioredoxin reductase from Giardia duodenalis | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, SODIUM ION, Thioredoxin reductase | | Authors: | Fiorillo, A, Ilari, A, Lalle, M. | | Deposit date: | 2016-10-21 | | Release date: | 2017-05-17 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Structural characterization of Giardia duodenalis thioredoxin reductase (gTrxR) and computational analysis of its interaction with NBDHEX.
Eur J Med Chem, 135, 2017
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7LW9
 | | Human Exonuclease 5 crystal structure in complex with ssDNA, Sm, and Na | | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, DNA (5'-D(*AP*TP*TP*GP*CP*TP*GP*AP*AP*GP*GP*G)-3'), ... | | Authors: | Tsai, C.L, Tainer, J.A. | | Deposit date: | 2021-02-28 | | Release date: | 2021-07-14 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.71 Å) | | Cite: | EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart.
Mol.Cell, 81, 2021
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5LZ9
 | | Fragment-based inhibitors of Lipoprotein associated Phospholipase A2 | | Descriptor: | 2-fluoranyl-5-[2-[(4~{S})-4-[4-methyl-1,1-bis(oxidanylidene)thian-4-yl]-2-oxidanylidene-pyrrolidin-1-yl]ethoxy]benzenecarbonitrile, CHLORIDE ION, Platelet-activating factor acetylhydrolase, ... | | Authors: | Woolford, A, Day, P. | | Deposit date: | 2016-09-29 | | Release date: | 2016-12-21 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2).
J. Med. Chem., 59, 2016
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3HM6
 | | Crystal structure of the cytoplasmic domain of human plexin B1 | | Descriptor: | Plexin-B1, UNKNOWN ATOM OR ION, Unknown peptide | | Authors: | Tong, Y, He, H, Shen, L, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | | Deposit date: | 2009-05-28 | | Release date: | 2009-06-09 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.402 Å) | | Cite: | Structure and function of the intracellular region of the plexin-b1 transmembrane receptor.
J.Biol.Chem., 284, 2009
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8UTV
 | | KIF1A[1-393] P305L mutant ADP bound in complex with a microtubule | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Benoit, M.P.M.H, Rao, L, Asenjo, A.B, Gennerich, A, Sosa, H. | | Deposit date: | 2023-10-31 | | Release date: | 2024-06-12 | | Last modified: | 2024-07-31 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Cryo-EM unveils kinesin KIF1A's processivity mechanism and the impact of its pathogenic variant P305L.
Nat Commun, 15, 2024
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6PQI
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6QNV
 | | Fibrinogen-like globe domain of Human Tenascin-C | | Descriptor: | Tenascin | | Authors: | Coker, J.A, Bezerra, G.A, Bradshaw, W.J, Zhang, M, Yosaatmadja, Y, Fernandez-Cid, A, Shrestha, L, Burgess-Brown, N, Gileadi, O, Arrowsmith, C.H, Bountra, C, Midwood, K.S, Yue, W.W, Marsden, B.D, Structural Genomics Consortium (SGC) | | Deposit date: | 2019-02-12 | | Release date: | 2019-02-27 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Fibrinogen-like globe domain of Human Tenascin-C
To Be Published
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8UTR
 | | KIF1A[1-393] ADP bound in complex with a microtubule | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Benoit, M.P.M.H, Rao, L, Asenjo, A.B, Gennerich, A, Sosa, H. | | Deposit date: | 2023-10-31 | | Release date: | 2024-06-12 | | Last modified: | 2024-07-31 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Cryo-EM unveils kinesin KIF1A's processivity mechanism and the impact of its pathogenic variant P305L.
Nat Commun, 15, 2024
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2HIQ
 | | Crystal structure of JW1657 from Escherichia coli | | Descriptor: | Hypothetical protein ydhR | | Authors: | Chen, L.Q, Chen, L.R, Liu, Z.-J, Temple, W, Lee, D, Chang, S.-H, Rose, J.P, Ebihara, A, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG) | | Deposit date: | 2006-06-29 | | Release date: | 2006-09-12 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of JW1657 from Escherichia coli at 2.0A resolution
To be Published
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