7LWA

Human Exonuclease 5 crystal structure (T88E) in complex with ssDNA and Mg

Summary for 7LWA

• Entry DOI: 10.2210/pdb7lwa/pdb
• Descriptor: Exonuclease V, DNA (5'-D(*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), IRON/SULFUR CLUSTER, ... (6 entities in total)
• Functional Keywords: hydrolase, hydrolase-dna complex, hydrolase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 42928.33

Authors

Tsai, C.L.,Tainer, J.A. (deposition date: 2021-02-28, release date: 2021-07-14, Last modification date: 2023-10-18)

• Primary citation: Hambarde, S.,Tsai, C.L.,Pandita, R.K.,Bacolla, A.,Maitra, A.,Charaka, V.,Hunt, C.R.,Kumar, R.,Limbo, O.,Le Meur, R.,Chazin, W.J.,Tsutakawa, S.E.,Russell, P.,Schlacher, K.,Pandita, T.K.,Tainer, J.A.; EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart.; Mol.Cell, 81:2989-, 2021; PubMed: 34197737; DOI: 10.1016/j.molcel.2021.05.027

Experimental method

X-RAY DIFFRACTION (2.85 Å)