7LWA

Human Exonuclease 5 crystal structure (T88E) in complex with ssDNA and Mg

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004518	molecular_function	nuclease activity
A	0004527	molecular_function	exonuclease activity
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006281	biological_process	DNA repair
A	0006974	biological_process	DNA damage response
A	0008310	molecular_function	single-stranded DNA 3'-5' DNA exonuclease activity
A	0016787	molecular_function	hydrolase activity
A	0036297	biological_process	interstrand cross-link repair
A	0045145	molecular_function	single-stranded DNA 5'-3' DNA exonuclease activity
A	0046872	molecular_function	metal ion binding
A	0051536	molecular_function	iron-sulfur cluster binding
A	0051539	molecular_function	4 iron, 4 sulfur cluster binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0007744|PDB:7LW7, ECO:0007744|PDB:7LW8, ECO:0007744|PDB:7LW9, ECO:0007744|PDB:7LWA

Chain	Residue	Details
A	CYS92
A	CYS346

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0007744|PDB:7LWA

Chain	Residue	Details
A	ASP182
A	GLU196

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0007744|PDB:7LW7, ECO:0007744|PDB:7LW8, ECO:0007744|PDB:7LWA

Chain	Residue	Details
A	CYS343
A	CYS352

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