7LWA
Human Exonuclease 5 crystal structure (T88E) in complex with ssDNA and Mg
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Exonuclease V | polymer | 346 | 38885.0 | 1 | UniProt (Q9H790) Pfam (PF09810) In PDB | Homo sapiens (Human) | Exo V, hExo5, Defects in morphology protein 1 homolog |
| 2 | B | DNA (5'-D(*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3') | polymer | 12 | 3605.4 | 1 | synthetic construct | ||
| 3 | A | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 1 | Chemie (SF4) | |||
| 4 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | water | water | 18.0 | 25 | Chemie (HOH) |
Sequence modifications
A: 31 - 373 (UniProt: Q9H790)
| PDB | External Database | Details |
|---|---|---|
| Ser 28 | - | expression tag |
| Asn 29 | - | expression tag |
| Ala 30 | - | expression tag |
| Glu 88 | Thr 88 | engineered mutation |
| Val 172 | Gly 172 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 42490.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 438.0 | |
| All* | Total formula weight | 42928.3 |
