7MWR
 
 | | Structure of De Novo designed beta sheet heterodimer LHD101A53/B4 | | 分子名称: | LHD101A54, LHD101B4, MALONATE ION | | 著者 | Bera, A.K, Sahtoe, D.D, Kang, A, Praetorius, F, Baker, D. | | 登録日 | 2021-05-17 | | 公開日 | 2022-01-19 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Reconfigurable asymmetric protein assemblies through implicit negative design.
Science, 375, 2022
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8SF5
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8C7W
 | | Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2304 | | 分子名称: | 1,2-ETHANEDIOL, 6-methyl-9-piperazin-1-yl-4-(3,4,5-trimethoxyphenyl)-5,7-dihydropyrido[4,3-d][2]benzazepine, Activin receptor type I, ... | | 著者 | Cros, J, Williams, E.P, Sweeney, M.N, Smil, D, Gonzalez-Alvarez, H, Al-awar, R, Bullock, A.N. | | 登録日 | 2023-01-17 | | 公開日 | 2023-02-08 | | 最終更新日 | 2024-08-14 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | Discovery of Conformationally Constrained ALK2 Inhibitors.
J.Med.Chem., 67, 2024
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6VZG
 | | Cryo-EM structure of Sth1-Arp7-Arp9-Rtt102 | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Actin-like protein ARP9, Actin-related protein 7, ... | | 著者 | Leschziner, A.E, Baker, R.W. | | 登録日 | 2020-02-28 | | 公開日 | 2020-12-02 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Structural insights into assembly and function of the RSC chromatin remodeling complex.
Nat.Struct.Mol.Biol., 28, 2021
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5NKP
 | | Crystal structure of the human KLHL3 Kelch domain in complex with a WNK3 peptide | | 分子名称: | CHLORIDE ION, CITRIC ACID, Kelch-like protein 3, ... | | 著者 | Chen, Z, Sorrell, F.J, Pinkas, D.M, Williams, E, Mathea, S, Goubin, S, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Burgess-Brown, N, Bountra, C, Bullock, A. | | 登録日 | 2017-03-31 | | 公開日 | 2017-05-03 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal structure of the human KLHL3 Kelch domain in complex with a WNK3 peptide
To Be Published
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6TK6
 | | Femtosecond to millisecond structural changes in a light-driven sodium pump: Dark structure in neutral conditions with attached light datasets at 800fs, 2ps, 100ps, 1ns, 16ns, 1us, 30us, 150us, 1ms and 20ms | | 分子名称: | EICOSANE, RETINAL, Sodium pumping rhodopsin | | 著者 | Skopintsev, P, Ehrenberg, D, Weinert, T, James, D, Kar, R, Johnson, P, Ozerov, D, Furrer, A, Martiel, I, Dworkowski, F, Nass, K, Knopp, G, Cirelli, C, Gashi, D, Mous, S, Wranik, M, Gruhl, T, Kekilli, D, Bruenle, S, Deupi, X, Schertler, G.F.X, Benoit, R, Panneels, V, Nogly, P, Schapiro, I, Milne, C, Heberle, J, Standfuss, J. | | 登録日 | 2019-11-28 | | 公開日 | 2020-05-27 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Femtosecond-to-millisecond structural changes in a light-driven sodium pump.
Nature, 583, 2020
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7N5F
 | | Structure of Mechanosensitive Ion Channel Flycatcher1 Protomer in 'Down' conformation in GDN | | 分子名称: | Mechanosensitive ion channel Flycatcher1, PALMITIC ACID | | 著者 | Jojoa-Cruz, S, Saotome, K, Lee, W.H, Patapoutian, A, Ward, A.B. | | 登録日 | 2021-06-05 | | 公開日 | 2022-02-16 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structural insights into the Venus flytrap mechanosensitive ion channel Flycatcher1.
Nat Commun, 13, 2022
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6TK4
 | | Femtosecond to millisecond structural changes in a light-driven sodium pump: 1ns+16ns structure of KR2 with extrapolated, light and dark datasets | | 分子名称: | EICOSANE, RETINAL, Sodium pumping rhodopsin | | 著者 | Skopintsev, P, Ehrenberg, D, Weinert, T, James, D, Kar, R, Johnson, P, Ozerov, D, Furrer, A, Martiel, I, Dworkowski, F, Nass, K, Knopp, G, Cirelli, C, Gashi, D, Mous, S, Wranik, M, Gruhl, T, Kekilli, D, Bruenle, S, Deupi, X, Schertler, G.F.X, Benoit, R, Panneels, V, Nogly, P, Schapiro, I, Milne, C, Heberle, J, Standfuss, J. | | 登録日 | 2019-11-28 | | 公開日 | 2020-05-27 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Femtosecond-to-millisecond structural changes in a light-driven sodium pump.
Nature, 583, 2020
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7B0B
 | | Fab HbnC3t1p1_C6 bound to SARS-CoV-2 RBD | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab heavy chain, IGK@ protein, ... | | 著者 | Borenstein-Katz, A, Diskin, R. | | 登録日 | 2020-11-19 | | 公開日 | 2021-12-01 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | | 主引用文献 | Somatic hypermutation introduces bystander mutations that prepare SARS-CoV-2 antibodies for emerging variants.
Immunity, 56, 2023
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7N5D
 | | Composite Structure of Mechanosensitive Ion Channel Flycatcher1 in GDN | | 分子名称: | Mechanosensitive ion channel Flycatcher1, PALMITIC ACID | | 著者 | Jojoa-Cruz, S, Saotome, K, Lee, W.H, Patapoutian, A, Ward, A.B. | | 登録日 | 2021-06-05 | | 公開日 | 2022-02-16 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural insights into the Venus flytrap mechanosensitive ion channel Flycatcher1.
Nat Commun, 13, 2022
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7N5G
 | | Structure of Mechanosensitive Ion Channel Flycatcher1 Protomer in 'Up' conformation in GDN | | 分子名称: | Mechanosensitive ion channel Flycatcher1, PALMITIC ACID | | 著者 | Jojoa-Cruz, S, Saotome, K, Lee, W.H, Patapoutian, A, Ward, A.B. | | 登録日 | 2021-06-05 | | 公開日 | 2022-02-16 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | | 主引用文献 | Structural insights into the Venus flytrap mechanosensitive ion channel Flycatcher1.
Nat Commun, 13, 2022
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6W0F
 | | Closed-gate KcsA soaked in 0mM KCl/5mM BaCl2 | | 分子名称: | Fab Heavy Chain, Fab Light Chain, POTASSIUM ION, ... | | 著者 | Rohaim, A, Gong, L, Li, J. | | 登録日 | 2020-02-29 | | 公開日 | 2020-07-08 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Open and Closed Structures of a Barium-Blocked Potassium Channel.
J.Mol.Biol., 432, 2020
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7T7G
 | | Imipenem-OXA-23 2 minute complex | | 分子名称: | (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carbox ylic acid, Beta-lactamase OXA-23 | | 著者 | Smith, C.A, Stewart, N.K, Vakulenko, S.B. | | 登録日 | 2021-12-15 | | 公開日 | 2022-05-04 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | C6 Hydroxymethyl-Substituted Carbapenem MA-1-206 Inhibits the Major Acinetobacter baumannii Carbapenemase OXA-23 by Impeding Deacylation.
Mbio, 13, 2022
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8C4I
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7N5E
 | | Structure of Mechanosensitive Ion Channel Flycatcher1 in GDN | | 分子名称: | Mechanosensitive ion channel Flycatcher1, PALMITIC ACID | | 著者 | Jojoa-Cruz, S, Saotome, K, Lee, W.H, Patapoutian, A, Ward, A.B. | | 登録日 | 2021-06-05 | | 公開日 | 2022-02-16 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural insights into the Venus flytrap mechanosensitive ion channel Flycatcher1.
Nat Commun, 13, 2022
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8RJC
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8OJN
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8OML
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7ZNF
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3MJB
 | | Cricket Paralysis Virus IGR IRES Domain 3 RNA bound to sulfate | | 分子名称: | Domain 3 of the cricket paralysis virus intergenic region IRES RNA, RNA (5'-R(P*UP*AP*AP*GP*AP*AP*AP*UP*UP*UP*AP*CP*CP*U)-3'), SULFATE ION | | 著者 | Kieft, J.S, Golden, B.L, Costantino, D.A, Chase, E. | | 登録日 | 2010-04-12 | | 公開日 | 2010-05-19 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Identification and characterization of anion binding sites in RNA.
Rna, 16, 2010
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8ONF
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8ONC
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8BZ3
 | | Structure od the carbohydrate reconition domain of Gal3 in comples with SAF-2-010 | | 分子名称: | Galectin-3, [(2~{S},3~{R},4~{S},5~{S},6~{R})-2-[(2~{R},3~{S},4~{R},5~{R},6~{S})-5-acetamido-2-(hydroxymethyl)-6-(4-nitrophenoxy)-4-oxidanyl-oxan-3-yl]oxy-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-4-yl] hydrogen sulfate | | 著者 | Medrano, F.J, Romero, A. | | 登録日 | 2022-12-14 | | 公開日 | 2023-03-01 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.31 Å) | | 主引用文献 | Selectively Modified Lactose and N -Acetyllactosamine Analogs at Three Key Positions to Afford Effective Galectin-3 Ligands.
Int J Mol Sci, 24, 2023
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5NFE
 | | Neutron structure of human transthyretin (TTR) T119M mutant at room temperature to 1.85A resolution | | 分子名称: | Transthyretin | | 著者 | Yee, A.W, Moulin, M, Blakeley, M.P, Ostermann, A, Cooper, J.B, Haertlein, M, Mitchell, E.P, Forsyth, V.T. | | 登録日 | 2017-03-14 | | 公開日 | 2019-01-02 | | 最終更新日 | 2024-05-01 | | 実験手法 | NEUTRON DIFFRACTION (1.853 Å), X-RAY DIFFRACTION | | 主引用文献 | A molecular mechanism for transthyretin amyloidogenesis.
Nat Commun, 10, 2019
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6MR9
 | | E. coli DHFR complex with a reaction intermediate | | 分子名称: | (6S)-5,6,7,8-TETRAHYDROFOLATE, CHLORIDE ION, Dihydrofolate reductase, ... | | 著者 | Cao, H, Rodrigues, J, Benach, J, Frommelt, A, Morisco, L, Koss, J, Shakhnovich, E, Skolnick, J. | | 登録日 | 2018-10-12 | | 公開日 | 2019-05-15 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Time-resolved x-ray crystallography capture of a slow reaction tetrahydrofolate intermediate.
Struct Dyn., 6, 2019
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