7T7G

Imipenem-OXA-23 2 minute complex

Summary for 7T7G

• Entry DOI: 10.2210/pdb7t7g/pdb
• Related: 7T7D
• Descriptor: Beta-lactamase OXA-23, (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carbox ylic acid (3 entities in total)
• Functional Keywords: antibiotic resistance, complex, hydrolase
• Biological source: Acinetobacter baumannii
• Total number of polymer chains: 1
• Total formula weight: 27991.30

Authors

Smith, C.A.,Stewart, N.K.,Vakulenko, S.B. (deposition date: 2021-12-15, release date: 2022-05-04, Last modification date: 2023-11-15)

• Primary citation: Stewart, N.K.,Toth, M.,Alqurafi, M.A.,Chai, W.,Nguyen, T.Q.,Quan, P.,Lee, M.,Buynak, J.D.,Smith, C.A.,Vakulenko, S.B.; C6 Hydroxymethyl-Substituted Carbapenem MA-1-206 Inhibits the Major Acinetobacter baumannii Carbapenemase OXA-23 by Impeding Deacylation.; Mbio, 13:e0036722-e0036722, 2022; PubMed: 35420470; DOI: 10.1128/mbio.00367-22

Experimental method

X-RAY DIFFRACTION (2.5 Å)