7P7X
| Crystal structure of D-amino acid transaminase from Haliscomenobacter hydrossis (holo form). | 分子名称: | ACETATE ION, Aminotransferase class IV, PHOSPHATE ION, ... | 著者 | Boyko, K.M, Nikolaeva, A.Y, Bakunova, A.K, Rakitina, T.V, Bezsudnova, E.Y, Popov, V.O. | 登録日 | 2021-07-20 | 公開日 | 2021-07-28 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The Uncommon Active Site of D-Amino Acid Transaminase from Haliscomenobacter hydrossis : Biochemical and Structural Insights into the New Enzyme. Molecules, 26, 2021
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8FMF
| Structure of CBASS Cap5 from Pseudomonas syringae as an activated tetramer with the cyclic dinucleotide 3'2'-c-diAMP ligand (1 tetramer in the AU) | 分子名称: | Cyclic (adenosine-(2'-5')-monophosphate-adenosine-(3'-5')-monophosphate, GLYCEROL, HEXAETHYLENE GLYCOL, ... | 著者 | Rechkoblit, O, Kreitler, D.F, Aggarwal, A.K. | 登録日 | 2022-12-23 | 公開日 | 2024-02-07 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Activation of CBASS Cap5 endonuclease immune effector by cyclic nucleotides. Nat.Struct.Mol.Biol., 31, 2024
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5NJR
| Mix-and-diffuse serial synchrotron crystallography: structure of N,N',N''-Triacetylchitotriose bound to Lysozyme with 50s time-delay, phased with 4ET8 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Lysozyme C, ... | 著者 | Oberthuer, D, Meents, A, Beyerlein, K.R, Chapman, H.N, Lieseke, J. | 登録日 | 2017-03-29 | 公開日 | 2017-10-18 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Mix-and-diffuse serial synchrotron crystallography. IUCrJ, 4, 2017
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6PJC
| HIV-1 Protease NL4-3 WT in Complex with LR4-41 | 分子名称: | (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,4S,5S)-5-{[(2,6-dimethylphenoxy)acetyl]amino}-4-hydroxy-1,6-diphenylhexan-2-yl]carbamate, Protease NL4-3, SULFATE ION | 著者 | Lockbaum, G.J, Rusere, L.N, Henes, M, Kosovrasti, K, Lee, S.K, Spielvogel, E, Nalivaika, E.A, Swanstrom, R, KurtYilmaz, N, Schiffer, C.A, Ali, A. | 登録日 | 2019-06-28 | 公開日 | 2020-07-01 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.965 Å) | 主引用文献 | Structural Analysis of Potent Hybrid HIV-1 Protease Inhibitors Containing Bis-tetrahydrofuran in a Pseudosymmetric Dipeptide Isostere. J.Med.Chem., 63, 2020
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5NL9
| Crystal structure of a peroxide stress regulator from Leptospira interrogans | 分子名称: | POTASSIUM ION, Transcriptional regulator (FUR family), UNKNOWN ATOM OR ION, ... | 著者 | Saul, F.A, Haouz, A, Picardeau, M, Benaroudj, N. | 登録日 | 2017-04-04 | 公開日 | 2017-11-22 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure and function of the Leptospira interrogans peroxide stress regulator (PerR), an atypical PerR devoid of a structural metal-binding site. J. Biol. Chem., 293, 2018
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6VIF
| Human LRH-1 ligand-binding domain bound to agonist cpd 15 and fragment of coregulator TIF-2 | 分子名称: | N-[(8beta,11alpha,12alpha)-8-{[methyl(phenyl)amino]methyl}-1,6:7,14-dicycloprosta-1(6),2,4,7(14)-tetraen-11-yl]sulfuric diamide, Nuclear receptor coactivator 2, Nuclear receptor subfamily 5 group A member 2 | 著者 | Cato, M.L, Ortlund, E.A. | 登録日 | 2020-01-13 | 公開日 | 2020-06-10 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | Development of a new class of liver receptor homolog-1 (LRH-1) agonists by photoredox conjugate addition. Bioorg.Med.Chem.Lett., 30, 2020
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6Z8D
| Human Picobirnavirus CP VLP | 分子名称: | Capsid protein precursor | 著者 | Ortega-Esteban, A, Mata, C.P, Rodriguez-Espinosa, M.J, Luque, D, Irigoyen, N, Rodriguez, J.M, de Pablo, P.J, Caston, J.R. | 登録日 | 2020-06-02 | 公開日 | 2020-09-23 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.63 Å) | 主引用文献 | Cryo-electron Microscopy Structure, Assembly, and Mechanics Show Morphogenesis and Evolution of Human Picobirnavirus. J.Virol., 94, 2020
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6PLF
| Crystal structure of human PHGDH complexed with Compound 1 | 分子名称: | 1,2-ETHANEDIOL, 4-{(1S)-1-[(5-chloro-6-{[(5S)-2-oxo-1,3-oxazolidin-5-yl]methoxy}-1H-indole-2-carbonyl)amino]-2-hydroxyethyl}benzoic acid, D-3-phosphoglycerate dehydrogenase | 著者 | Olland, A, Lakshminarasimhan, D, White, A, Suto, R.K. | 登録日 | 2019-06-30 | 公開日 | 2019-07-24 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells. Bioorg.Med.Chem.Lett., 29, 2019
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6ZJQ
| Cold-adapted beta-D-galactosidase from Arthrobacter sp. 32cB mutant E517Q in complex with galactose | 分子名称: | ACETATE ION, Beta-galactosidase, MALONATE ION, ... | 著者 | Rutkiewicz, M, Bujacz, A, Bujacz, G. | 登録日 | 2020-06-29 | 公開日 | 2020-08-05 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Mapping the Transglycosylation Relevant Sites of Cold-Adapted beta-d-Galactosidase fromArthrobactersp. 32cB. Int J Mol Sci, 21, 2020
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6Z9F
| 1.56 A structure of human apoferritin obtained from data subset of Titan Mono-BCOR microscope | 分子名称: | Ferritin heavy chain, SODIUM ION | 著者 | Yip, K.M, Fischer, N, Paknia, E, Chari, A, Stark, H. | 登録日 | 2020-06-03 | 公開日 | 2020-06-24 | 最終更新日 | 2021-02-10 | 実験手法 | ELECTRON MICROSCOPY (1.56 Å) | 主引用文献 | Atomic-resolution protein structure determination by cryo-EM. Nature, 587, 2020
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6VO3
| AMC009 SOSIP.v4.2 in complex with PGV04 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, AMC009 SOSIP.v4.2 envelope glycoprotein gp120, ... | 著者 | Cottrell, C.A, de Val, N, Ward, A.B. | 登録日 | 2020-01-29 | 公開日 | 2020-09-23 | 最終更新日 | 2020-12-09 | 実験手法 | ELECTRON MICROSCOPY (4.25 Å) | 主引用文献 | Neutralizing Antibody Responses Induced by HIV-1 Envelope Glycoprotein SOSIP Trimers Derived from Elite Neutralizers. J.Virol., 94, 2020
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7QNV
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8FMG
| Structure of CBASS Cap5 from Pseudomonas syringae as an activated tetramer with the cyclic dinucleotide 3'2'-c-diAMP ligand (3 tetramers in the AU) | 分子名称: | Cyclic (adenosine-(2'-5')-monophosphate-adenosine-(3'-5')-monophosphate, MAGNESIUM ION, SAVED domain-containing protein, ... | 著者 | Rechkoblit, O, Kreitler, D.F, Aggarwal, A.K. | 登録日 | 2022-12-23 | 公開日 | 2024-02-07 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Activation of CBASS Cap5 endonuclease immune effector by cyclic nucleotides. Nat.Struct.Mol.Biol., 31, 2024
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8FMH
| Structure of CBASS Cap5 from Pseudomonas syringae as an activated tetramer with the cyclic dinucleotide 3'2'-c-dGAMP ligand (2 tetramers in the AU) | 分子名称: | 3'2'-cGAMP, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Rechkoblit, O, Kreitler, D.F, Aggarwal, A.K. | 登録日 | 2022-12-23 | 公開日 | 2024-02-07 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | 主引用文献 | Activation of CBASS Cap5 endonuclease immune effector by cyclic nucleotides. Nat.Struct.Mol.Biol., 31, 2024
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7QOB
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5NOB
| Crystal structure of human tankyrase 2 in complex with OD336 | 分子名称: | 1-[3-[4-(2-chlorophenyl)-5-pyrimidin-4-yl-1,2,4-triazol-3-yl]cyclobutyl]-2-oxidanylidene-3~{H}-benzimidazole-5-carbonitrile, Tankyrase-2, ZINC ION | 著者 | Ignatev, A, Lehtio, L. | 登録日 | 2017-04-11 | 公開日 | 2017-11-29 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach. J. Med. Chem., 60, 2017
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7ONU
| Structure of human mitochondrial RNase P in complex with mitochondrial pre-tRNA-Tyr | 分子名称: | 3-hydroxyacyl-CoA dehydrogenase type-2, MAGNESIUM ION, Mitochondrial Precursor tRNA-Tyr, ... | 著者 | Bhatta, A, Dienemann, C, Cramer, P, Hillen, H.S. | 登録日 | 2021-05-26 | 公開日 | 2021-08-11 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis of RNA processing by human mitochondrial RNase P. Nat.Struct.Mol.Biol., 28, 2021
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7P5M
| Cryo-EM structure of human TTYH2 in lipid nanodiscs | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein tweety homolog 2 | 著者 | Sukalskaia, A, Straub, M.S, Sawicka, M, Deneka, D, Dutzler, R. | 登録日 | 2021-07-14 | 公開日 | 2021-08-11 | 最終更新日 | 2021-09-08 | 実験手法 | ELECTRON MICROSCOPY (3.92 Å) | 主引用文献 | Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions. Nat Commun, 12, 2021
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7P5C
| Cryo-EM structure of human TTYH3 in Ca2+ and GDN | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein tweety homolog 3 | 著者 | Sukalskaia, A, Straub, M.S, Sawicka, M, Deneka, D, Dutzler, R. | 登録日 | 2021-07-14 | 公開日 | 2021-08-11 | 最終更新日 | 2021-09-08 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions. Nat Commun, 12, 2021
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7BE6
| Structure of DDR1 receptor tyrosine kinase in complex with inhibitor SR159 | 分子名称: | 1,2-ETHANEDIOL, 5-amino-N-(4-(((2S)-4-cyclohexyl-1-((1-(methylsulfonyl)piperidin-3-yl)amino)-1-oxobutan-2-yl)carbamoyl)benzyl)-1-phenyl-1H-pyrazole-4-carboxamide, Epithelial discoidin domain-containing receptor 1, ... | 著者 | Pinkas, D.M, Bufton, J.C, Roehm, S, Joerger, A.C, Knapp, S, Bullock, A.N, Structural Genomics Consortium (SGC) | 登録日 | 2020-12-22 | 公開日 | 2021-03-03 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.87081933 Å) | 主引用文献 | Development of a Selective Dual Discoidin Domain Receptor (DDR)/p38 Kinase Chemical Probe. J.Med.Chem., 64, 2021
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6W58
| hPGDS complexed with an aza-quinoline | 分子名称: | 7-(azetidin-1-yl)-~{N}-[4-(2-oxidanylpropan-2-yl)cyclohexyl]-1,6-naphthyridine-3-carboxamide, GLUTATHIONE, Hematopoietic prostaglandin D synthase | 著者 | Elkins, P.A, Ward, P. | 登録日 | 2020-03-12 | 公開日 | 2020-11-04 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.395 Å) | 主引用文献 | The exploration of aza-quinolines as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors with low brain exposure. Bioorg.Med.Chem., 28, 2020
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7P54
| Cryo-EM structure of human TTYH2 in GDN | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein tweety homolog 2 | 著者 | Sukalskaia, A, Straub, M.S, Sawicka, M, Deneka, D, Dutzler, R. | 登録日 | 2021-07-14 | 公開日 | 2021-08-11 | 最終更新日 | 2021-09-08 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions. Nat Commun, 12, 2021
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7U15
| TMEM106B(120-254) singlet amyloid fibril from frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) type B case 2 (case 7). | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B | 著者 | Fitzpatrick, A.W.P, Stowell, M.H.B, Chang, A, Xiang, X, Wang, J, Lee, C, Arakhamia, T, Simjanoska, M, Wang, C, Carlomagno, Y, Zhang, G, Dhingra, S, Thierry, M, Perneel, J, Heeman, B, Forgrave, L.M, DeTure, M, DeMarco, M.L, Cook, C.N, Rademakers, R, Dickson, D, Petrucelli, L, Mackenzie, I.R.A. | 登録日 | 2022-02-19 | 公開日 | 2022-03-23 | 最終更新日 | 2022-04-27 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases. Cell, 185, 2022
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5NEK
| Crystal structure of the polysaccharide deacetylase Bc1974 from Bacillus cereus in complex with acetazolamide | 分子名称: | 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, ACETATE ION, Peptidoglycan N-acetylglucosamine deacetylase, ... | 著者 | Andreou, A, Giastas, P, Eliopoulos, E.E. | 登録日 | 2017-03-10 | 公開日 | 2018-02-21 | 最終更新日 | 2019-10-16 | 実験手法 | X-RAY DIFFRACTION (3.057 Å) | 主引用文献 | Structures of the Peptidoglycan N-Acetylglucosamine Deacetylase Bc1974 and Its Complexes with Zinc Metalloenzyme Inhibitors. Biochemistry, 57, 2018
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7P5J
| Cryo-EM structure of human TTYH1 in GDN | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein tweety homolog 1 | 著者 | Sukalskaia, A, Straub, M.S, Sawicka, M, Deneka, D, Dutzler, R. | 登録日 | 2021-07-14 | 公開日 | 2021-08-11 | 最終更新日 | 2021-09-08 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions. Nat Commun, 12, 2021
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