7BE6

Structure of DDR1 receptor tyrosine kinase in complex with inhibitor SR159

Summary for 7BE6

• Entry DOI: 10.2210/pdb7be6/pdb
• Descriptor: Epithelial discoidin domain-containing receptor 1, 1,2-ETHANEDIOL, PHOSPHATE ION, ... (6 entities in total)
• Functional Keywords: ddr1 receptor tyrosine kinase, kinase inhibitor, structure-based design, structural genomics consortium, sgc, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 37043.43

Authors

Pinkas, D.M.,Bufton, J.C.,Roehm, S.,Joerger, A.C.,Knapp, S.,Bullock, A.N.,Structural Genomics Consortium (SGC) (deposition date: 2020-12-22, release date: 2021-03-03, Last modification date: 2024-01-31)

• Primary citation: Rohm, S.,Berger, B.T.,Schroder, M.,Chatterjee, D.,Mathea, S.,Joerger, A.C.,Pinkas, D.M.,Bufton, J.C.,Tjaden, A.,Kovooru, L.,Kudolo, M.,Pohl, C.,Bullock, A.N.,Muller, S.,Laufer, S.,Knapp, S.; Development of a Selective Dual Discoidin Domain Receptor (DDR)/p38 Kinase Chemical Probe.; J.Med.Chem., 64:13451-13474, 2021; PubMed: 34506142; DOI: 10.1021/acs.jmedchem.1c00868

Experimental method

X-RAY DIFFRACTION (1.87081933411 Å)