7BE6
Structure of DDR1 receptor tyrosine kinase in complex with inhibitor SR159
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Epithelial discoidin domain-containing receptor 1 | polymer | 315 | 35754.1 | 1 | UniProt (Q08345) Pfam (PF07714) In PDB | Homo sapiens (Human) | Epithelial discoidin domain receptor 1,CD167 antigen-like family member A,Cell adhesion kinase,Discoidin receptor tyrosine kinase,HGK2,Mammary carcinoma kinase 10,MCK-10,Protein-tyrosine kinase 3A,Protein-tyrosine kinase RTK-6,TRK E,Tyrosine kinase DDR,Tyrosine-protein kinase CAK |
| 2 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 7 | Chemie (EDO) | |||
| 3 | A | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 4 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | A | 5-amino-N-(4-(((2S)-4-cyclohexyl-1-((1-(methylsulfonyl)piperidin-3-yl)amino)-1-oxobutan-2-yl)carbamoyl)benzyl)-1-phenyl-1H-pyrazole-4-carboxamide | non-polymer | 663.8 | 1 | Chemie (TJW) | |||
| 6 | water | water | 18.0 | 158 | Chemie (HOH) |
Sequence modifications
A: 601 - 913 (UniProt: Q08345)
| PDB | External Database | Details |
|---|---|---|
| Ser 599 | - | expression tag |
| Met 600 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35754.1 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1289.3 | |
| All* | Total formula weight | 37043.4 |
