7BE6

Structure of DDR1 receptor tyrosine kinase in complex with inhibitor SR159

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
A	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue EDO A 1001

Chain	Residue
A	MET810
A	ALA811
A	TRP812
A	ILE815
A	PHE845
A	VAL853
A	ASN856
A	ALA857
A	EDO1002

---

site_id	AC2
Number of Residues	7
Details	binding site for residue EDO A 1002

Chain	Residue
A	TRP827
A	PHE845
A	TYR869
A	LEU870
A	TRP888
A	EDO1001
A	HOH1111

---

site_id	AC3
Number of Residues	4
Details	binding site for residue EDO A 1003

Chain	Residue
A	SER892
A	ARG895
A	PRO897
A	HOH1138

---

site_id	AC4
Number of Residues	4
Details	binding site for residue EDO A 1004

Chain	Residue
A	GLY786
A	VAL804
A	HOH1122
A	HOH1129

---

site_id	AC5
Number of Residues	2
Details	binding site for residue EDO A 1005

Chain	Residue
A	ASP668
A	HOH1137

---

site_id	AC6
Number of Residues	6
Details	binding site for residue PO4 A 1006

Chain	Residue
A	GLY801
A	ARG802
A	ARG872
A	PRO874
A	ALA875
A	ARG903

---

site_id	AC7
Number of Residues	8
Details	binding site for residue SO4 A 1007

Chain	Residue
A	LYS671
A	TRP834
A	PHE845
A	LEU870
A	SER871
A	HOH1130
A	HOH1171
A	HOH1201

---

site_id	AC8
Number of Residues	5
Details	binding site for residue EDO A 1008

Chain	Residue
A	TRP812
A	GLU813
A	ARG890
A	GLU891
A	SER892

---

site_id	AC9
Number of Residues	17
Details	binding site for residue TJW A 1009

Chain	Residue
A	ALA653
A	GLU672
A	MET676
A	ILE685
A	THR701
A	ASP702
A	TYR703
A	MET704
A	GLY707
A	PHE762
A	HIS764
A	ILE782
A	ALA783
A	ASP784
A	GLN847
A	HOH1139
A	HOH1220

---

site_id	AD1
Number of Residues	3
Details	binding site for residue EDO A 1010

Chain	Residue
A	LYS655
A	GLU672
A	HOH1139

---

Functional Information from PROSITE/UniProt

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLATRNCLV

Chain	Residue	Details
A	PHE762-VAL774

---

site_id	PS00239
Number of Residues	9
Details	RECEPTOR_TYR_KIN_II Receptor tyrosine kinase class II signature. NLYagdYYR

Chain	Residue	Details
A	ASN790-ARG798

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"16337946","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"24509848","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---