5NOB
Crystal structure of human tankyrase 2 in complex with OD336
Summary for 5NOB
Entry DOI | 10.2210/pdb5nob/pdb |
Descriptor | Tankyrase-2, 1-[3-[4-(2-chlorophenyl)-5-pyrimidin-4-yl-1,2,4-triazol-3-yl]cyclobutyl]-2-oxidanylidene-3~{H}-benzimidazole-5-carbonitrile, ZINC ION, ... (4 entities in total) |
Functional Keywords | transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q9H2K2 |
Total number of polymer chains | 2 |
Total formula weight | 55668.14 |
Authors | Ignatev, A.,Lehtio, L. (deposition date: 2017-04-11, release date: 2017-11-29, Last modification date: 2024-01-17) |
Primary citation | Anumala, U.R.,Waaler, J.,Nkizinkiko, Y.,Ignatev, A.,Lazarow, K.,Lindemann, P.,Olsen, P.A.,Murthy, S.,Obaji, E.,Majouga, A.G.,Leonov, S.,von Kries, J.P.,Lehtio, L.,Krauss, S.,Nazare, M. Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach. J. Med. Chem., 60:10013-10025, 2017 Cited by PubMed: 29155568DOI: 10.1021/acs.jmedchem.7b00883 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
Download full validation report