5NOB

Crystal structure of human tankyrase 2 in complex with OD336

Summary for 5NOB

• Entry DOI: 10.2210/pdb5nob/pdb
• Descriptor: Tankyrase-2, 1-[3-[4-(2-chlorophenyl)-5-pyrimidin-4-yl-1,2,4-triazol-3-yl]cyclobutyl]-2-oxidanylidene-3~{H}-benzimidazole-5-carbonitrile, ZINC ION, ... (4 entities in total)
• Functional Keywords: transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: Q9H2K2
• Total number of polymer chains: 2
• Total formula weight: 55668.14

Authors

Ignatev, A.,Lehtio, L. (deposition date: 2017-04-11, release date: 2017-11-29, Last modification date: 2024-01-17)

• Primary citation: Anumala, U.R.,Waaler, J.,Nkizinkiko, Y.,Ignatev, A.,Lazarow, K.,Lindemann, P.,Olsen, P.A.,Murthy, S.,Obaji, E.,Majouga, A.G.,Leonov, S.,von Kries, J.P.,Lehtio, L.,Krauss, S.,Nazare, M.; Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach.; J. Med. Chem., 60:10013-10025, 2017; PubMed: 29155568; DOI: 10.1021/acs.jmedchem.7b00883

Experimental method

X-RAY DIFFRACTION (1.85 Å)