6RML
| Crystal structure of TOPBP1 BRCT0,1,2 in complex with a 53BP1 phosphopeptide | 分子名称: | 53BP1, DNA topoisomerase 2-binding protein 1 | 著者 | Day, M, Oliver, A.W, Pearl, L.H. | 登録日 | 2019-05-07 | 公開日 | 2019-06-12 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint. Elife, 8, 2019
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6HP7
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8IYB
| Structure insight into substrate recognition and catalysis by feruloyl esterase from Aspergillus sydowii | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(4-HYDROXY-3-METHOXYPHENYL)-2-PROPENOIC ACID, ... | 著者 | Phienluphon, A, Kondo, K, Mikami, B, Nagata, T, Katahira, M. | 登録日 | 2023-04-04 | 公開日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural insights into the molecular mechanisms of substrate recognition and hydrolysis by feruloyl esterase from Aspergillus sydowii. Int.J.Biol.Macromol., 253, 2023
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1LV8
| Crystal structure of calf spleen purine nucleoside phosphorylase in a new space group with full trimer in the asymmetric unit | 分子名称: | 2,6-DIAMINO-(S)-9-[2-(PHOSPHONOMETHOXY)PROPYL]PURINE, CALCIUM ION, PURINE NUCLEOSIDE PHOSPHORYLASE | 著者 | Bzowska, A, Koellner, G, Wielgus-Kutrowska, B, Stroh, A, Raszewski, G, Holy, A, Steiner, T, Frank, J. | 登録日 | 2002-05-27 | 公開日 | 2003-09-02 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of calf spleen purine nucleoside phosphorylase with two full trimers in the asymmetric unit: important implications for the mechanism of catalysis J.Mol.Biol., 342, 2004
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3KW8
| Two-domain laccase from Streptomyces coelicolor at 2.3 A resolution | 分子名称: | COPPER (II) ION, FE (III) ION, Putative copper oxidase, ... | 著者 | Skalova, T, Dohnalek, J, Kolenko, P, Duskova, J, Stepankova, A, Hasek, J, Ostergaard, L.H, Ostergaard, P.R. | 登録日 | 2009-12-01 | 公開日 | 2010-12-08 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | Structure of laccase from Streptomyces coelicolor after soaking with potassium hexacyanoferrate and at an improved resolution of 2.3 A Acta Crystallogr.,Sect.F, 67, 2011
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4QQO
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8ITL
| Cryo-EM structure of GIPR splice variant 1 (SV1) in complex with Gs protein | 分子名称: | Gastric inhibitory polypeptide receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhao, F.H, Hang, K.N, Zhou, Q.T, Shao, L.J, Li, H, Li, W.Z, Lin, S, Dai, A.T, Cai, X.Q, Liu, Y.Y, Xu, Y.N, Feng, W.B, Yang, D.H, Wang, M.W. | 登録日 | 2023-03-22 | 公開日 | 2023-10-18 | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | 主引用文献 | Molecular basis of signal transduction mediated by the human GIPR splice variants. Proc.Natl.Acad.Sci.USA, 120, 2023
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5FYQ
| Sirt2 in complex with a 13-mer trifluoroacetylated Ran peptide | 分子名称: | NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2, RAN AA 31-43, SULFATE ION, ... | 著者 | Knyphausen, P, de Boor, S, Scislowski, L, Extra, A, Baldus, L, Schacherl, M, Baumann, U, Neundorf, I, Lammers, M. | 登録日 | 2016-03-09 | 公開日 | 2016-05-25 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Insights Into Lysine-Deacetylation of Natively Folded Substrate Proteins by Sirtuins. J.Biol.Chem., 291, 2016
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8IYC
| Structure insight into substrate recognition and catalysis by feruloyl esterase from Aspergillus sydowii | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | 著者 | Phienluphon, A, Kondo, K, Mikami, B, Nagata, T, Katahira, M. | 登録日 | 2023-04-04 | 公開日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Structural insights into the molecular mechanisms of substrate recognition and hydrolysis by feruloyl esterase from Aspergillus sydowii. Int.J.Biol.Macromol., 253, 2023
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5C1V
| CRYSTAL STRUCTURE ANALYSIS OF CATALYTIC SUBUNIT OF HUMAN CALCINEURIN | 分子名称: | FE (III) ION, PHOSPHATE ION, Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform, ... | 著者 | Guasch, A, Fita, I, Perez-Luque, R, Aparicio, D, Aranguren-Ibanez, A, Perez-Riba, M. | 登録日 | 2015-06-15 | 公開日 | 2016-02-03 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.35 Å) | 主引用文献 | Calcineurin Undergoes a Conformational Switch Evoked via Peptidyl-Prolyl Isomerization. Plos One, 10, 2015
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5ZTP
| Carbonic anhydrase from Glaciozyma antarctica | 分子名称: | SULFATE ION, carbonic anhydrase | 著者 | Jaafar, N.R, Bakar, A.F.D, Murad, A.M.A, Mahadi, N.M, Jonet, M.A. | 登録日 | 2018-05-04 | 公開日 | 2018-05-23 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.96 Å) | 主引用文献 | Carbonic anhydrase from Glaciozyma antarctica To Be Published
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8IY8
| Structure insight into substrate recognition and catalysis by feruloyl esterase from Aspergillus sydowii | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, Feruloyl esterase | 著者 | Phienluphon, A, Kondo, K, Mikami, B, Nagata, T, Katahira, M. | 登録日 | 2023-04-04 | 公開日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural insights into the molecular mechanisms of substrate recognition and hydrolysis by feruloyl esterase from Aspergillus sydowii. Int.J.Biol.Macromol., 253, 2023
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6DZ1
| Studies of Ion Transport in K+ Channels | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, POTASSIUM ION, Potassium channel protein | 著者 | Langan, P.S, Vandavasi, V.G, Weiss, K.L, Wagner, A, Duman, R, El Omari, K, Afonine, P.V, Coates, L. | 登録日 | 2018-07-02 | 公開日 | 2018-11-14 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | Anomalous X-ray diffraction studies of ion transport in K+channels. Nat Commun, 9, 2018
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6K3X
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5GAO
| Head region of the yeast spliceosomal U4/U6.U5 tri-snRNP | 分子名称: | Pre-mRNA-splicing factor 8, Pre-mRNA-splicing helicase BRR2, Saccharomyces cerevisiae strain UOA_M2 chromosome 5 sequence, ... | 著者 | Nguyen, T.H.D, Galej, W.P, Bai, X.C, Oubridge, C, Scheres, S.H.W, Newman, A.J, Nagai, K. | 登録日 | 2015-12-15 | 公開日 | 2016-01-27 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution. Nature, 530, 2016
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3L4J
| Topoisomerase II-DNA cleavage complex, apo | 分子名称: | 3'-THIO-THYMIDINE-5'-PHOSPHATE, DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*CP*GP*TP*CP*AP*TP*CP*C)-3'), DNA (5'-D(*CP*GP*CP*GP*GP*TP*AP*GP*CP*AP*GP*TP*AP*GP*G)-3'), ... | 著者 | Schmidt, B.H, Burgin, A.B, Deweese, J.E, Osheroff, N, Berger, J.M. | 登録日 | 2009-12-20 | 公開日 | 2010-05-26 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases. Nature, 465, 2010
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6A2R
| Mycobacterium tuberculosis LexA C-domain II | 分子名称: | DI(HYDROXYETHYL)ETHER, LexA repressor | 著者 | Chandran, A.V, Srikalaivani, R, Paul, A, Vijayan, M. | 登録日 | 2018-06-12 | 公開日 | 2019-01-23 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Biochemical characterization of Mycobacterium tuberculosis LexA and structural studies of its C-terminal segment. Acta Crystallogr D Struct Biol, 75, 2019
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4R1G
| Structure of a putative peptidoglycan glycosyltransferase from Atopobium parvulum in complex with cloxacillin | 分子名称: | CLOXACILLIN (OPEN FORM), Peptidoglycan glycosyltransferase | 著者 | Filippova, E.V, Minasov, G, Kiryukhina, O, Clancy, S, Joachimiak, A, Anderson, W.F, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2014-08-05 | 公開日 | 2014-08-27 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Structure of a putative peptidoglycan glycosyltransferase from Atopobium parvulum in complex with cloxacillin To be Published
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4XW0
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6DZ6
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7JIK
| Human recombinant Beta-2-Glycoprotein 1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-glycoprotein 1, ... | 著者 | Klenotic, P.A, Yu, E.W.Y. | 登録日 | 2020-07-23 | 公開日 | 2021-07-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Beta-2-Glycoprotein I and it's role in APS To Be Published
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4QXD
| Crystal structure of Inositol Polyphosphate 1-Phosphatase from Entamoeba histolytica | 分子名称: | 3'(2'),5'-bisphosphate nucleotidase, putative, MAGNESIUM ION, ... | 著者 | Tarique, K.F, Abdul Rehman, S.A, Betzel, C, Gourinath, S. | 登録日 | 2014-07-19 | 公開日 | 2014-08-06 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Structure-based identification of inositol polyphosphate 1-phosphatase from Entamoeba histolytica Acta Crystallogr.,Sect.D, 70, 2014
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5SFP
| Crystal Structure of human phosphodiesterase 10 in complex with N-(2-chloropyridin-4-yl)-2-phenylpyrazolo[1,5-a]pyridine-6-carboxamide | 分子名称: | (8S)-N-(2-chloropyridin-4-yl)-2-phenylpyrazolo[1,5-a]pyridine-6-carboxamide, MAGNESIUM ION, ZINC ION, ... | 著者 | Joseph, C, Flohr, A, Benz, J, Schlatter, D, Rudolph, M.G. | 登録日 | 2022-01-21 | 公開日 | 2022-10-12 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A high quality, industrial data set for binding affinity prediction: performance comparison in different early drug discovery scenarios. J.Comput.Aided Mol.Des., 36, 2022
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4QYJ
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5C83
| Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Compound 21 | 分子名称: | (2R,5R)-4-[2-(6-benzyl-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl)-2-oxoethyl]-5-(methoxymethyl)-2-methylpiperazin-1-ium, E3 ubiquitin-protein ligase XIAP, ZINC ION | 著者 | Chessari, G, Buck, I.M, Day, J.E.H, Day, P.J, Iqbal, A, Johnson, C.N, Lewis, E.J, Martins, V, Miller, D, Reader, M, Rees, D.C, Rich, S.J, Tamanini, E, Vitorino, M, Ward, G.A, Williams, P.A, Williams, G, Wilsher, N.E, Woolford, A.J.-A. | 登録日 | 2015-06-25 | 公開日 | 2015-08-12 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP. J.Med.Chem., 58, 2015
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