5HG1
| Crystal Structure of Human Hexokinase 2 with cmpd 1, a C-2-substituted glucosamine | 分子名称: | 2-deoxy-2-{[(2E)-3-(3,4-dichlorophenyl)prop-2-enoyl]amino}-alpha-D-glucopyranose, 6-O-phosphono-beta-D-glucopyranose, CITRATE ANION, ... | 著者 | Campobasso, N, Zhao, B, Smallwood, A. | 登録日 | 2016-01-07 | 公開日 | 2016-03-30 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.76 Å) | 主引用文献 | Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors. Acs Med.Chem.Lett., 7, 2016
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4U7W
| The crystal structure of the terminal R domain from the myxalamid PKS-NRPS biosynthetic pathway | 分子名称: | ACETATE ION, MxaA, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Tsai, S.C, Keasling, J.D, Luo, R, Barajas, J.F, Phelan, R.M, Schaub, A.J, Kliewer, J. | 登録日 | 2014-07-31 | 公開日 | 2015-08-12 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.899 Å) | 主引用文献 | Comprehensive Structural and Biochemical Analysis of the Terminal Myxalamid Reductase Domain for the Engineered Production of Primary Alcohols. Chem.Biol., 22, 2015
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6TZ9
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5D2I
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7SIT
| Crystal structure of Voltage gated potassium ion channel, Kv 1.2 chimera-3m | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, OXYGEN ATOM, POTASSIUM ION, ... | 著者 | Reddi, R, Matulef, K, Riederer, E.A, Whorton, M.R, Valiyaveetil, F.I. | 登録日 | 2021-10-14 | 公開日 | 2022-05-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.32 Å) | 主引用文献 | Structural basis for C-type inactivation in a Shaker family voltage-gated K + channel. Sci Adv, 8, 2022
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5KCC
| Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with Oxabicyclic Heptene Sulfonamide (OBHS-N) | 分子名称: | (1S,2R,4S)-5,6-bis(4-hydroxyphenyl)-N-phenyl-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide, Estrogen receptor, NCOA2 | 著者 | Nwachukwu, J.C, Srinivasan, S, Zheng, Y, Wang, S, Min, J, Dong, C, Liao, Z, Cavett, V, Nowak, J, Houtman, R, Carlson, K.E, Josan, J.S, Elemento, O, Katzenellenbogen, J.A, Zhou, H.B, Nettles, K.W. | 登録日 | 2016-06-06 | 公開日 | 2016-11-16 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.386 Å) | 主引用文献 | Full antagonism of the estrogen receptor without a prototypical ligand side chain. Nat. Chem. Biol., 13, 2017
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6U0W
| Crystal structure of Staphylococcal nuclease variant Delta+PHS K133M at cryogenic temperature | 分子名称: | CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease | 著者 | Jeliazkov, J.R, Robinson, A.C, Berger, J.M, Garcia-Moreno E, B, Gray, J.G. | 登録日 | 2019-08-15 | 公開日 | 2019-08-28 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Toward the computational design of protein crystals with improved resolution. Acta Crystallogr D Struct Biol, 75, 2019
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8Q3R
| Cryo-EM structure of the DNA polymerase holoenzyme E9-A20-D4 of vaccinia virus | 分子名称: | DNA polymerase, DNA polymerase processivity factor component OPG148, Uracil-DNA glycosylase | 著者 | Burmeister, W.P, Ballandras-Colas, A, Boettcher, B, Grimm, C. | 登録日 | 2023-08-04 | 公開日 | 2024-05-08 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure and flexibility of the DNA polymerase holoenzyme of vaccinia virus. Plos Pathog., 20, 2024
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5JQ4
| Structure of a GNAT acetyltransferase SACOL1063 from Staphylococcus aureus | 分子名称: | 1,2-ETHANEDIOL, Acetyltransferase SACOL1063, CHLORIDE ION, ... | 著者 | Majorek, K.A, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2016-05-04 | 公開日 | 2016-06-29 | 最終更新日 | 2022-04-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Insight into the 3D structure and substrate specificity of previously uncharacterized GNAT superfamily acetyltransferases from pathogenic bacteria. Biochim.Biophys.Acta, 1865, 2016
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8AQW
| BA.4/5 SARS-CoV-2 Spike bound to mouse ACE2 (local) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2,Ig gamma-2A chain C region, ... | 著者 | Lau, K, Ni, D, Beckert, B, Nazarov, S, Myasnikov, A, Pojer, F, Stahlberg, H, Uchikawa, E. | 登録日 | 2022-08-13 | 公開日 | 2023-03-15 | 最終更新日 | 2023-04-19 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range. Plos Pathog., 19, 2023
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6QKL
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8VTT
| Meis1 homeobox domain bound to neomycin fragment | 分子名称: | Homeobox protein Meis1, RIBOSTAMYCIN, SULFATE ION | 著者 | Tomchick, D.R, Ahmed, M.S, Nguyen, N.U.N, Sadek, H.A. | 登録日 | 2024-01-27 | 公開日 | 2024-02-14 | 最終更新日 | 2024-09-11 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Identification of FDA-approved drugs that induce heart regeneration in mammals. Nat Cardiovasc Res, 3, 2024
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7JZT
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1M1K
| Co-crystal structure of azithromycin bound to the 50S ribosomal subunit of Haloarcula marismortui | 分子名称: | 23S RRNA, 5S RRNA, AZITHROMYCIN, ... | 著者 | Hansen, J.L, Ippolito, J.A, Ban, N, Nissen, P, Moore, P.B, Steitz, T.A. | 登録日 | 2002-06-19 | 公開日 | 2002-07-19 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | The structures of four macrolide antibiotics bound to the large ribosomal subunit. Mol.Cell, 10, 2002
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6W0H
| Closed-gate KcsA soaked in 5mM KCl/5mM BaCl2 | 分子名称: | Fab Heavy Chain, Fab Light Chain, POTASSIUM ION, ... | 著者 | Rohaim, A, Gong, L, Li, J. | 登録日 | 2020-02-29 | 公開日 | 2020-07-08 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Open and Closed Structures of a Barium-Blocked Potassium Channel. J.Mol.Biol., 432, 2020
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6HZN
| Crystal structure of human dermatan sulfate epimerase 1 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Hasan, M, Unge, J, Westergren-Thorsson, G, Ellervik, U, Mueller, U, Malmstrom, A, Tykesson, E. | 登録日 | 2018-10-23 | 公開日 | 2020-01-22 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | The structure of human dermatan sulfate epimerase 1 emphasizes the importance of C5-epimerization of glucuronic acid in higher organisms Chem Sci, 2020
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7K4P
| Crystal structure of Kemp Eliminase HG3 | 分子名称: | Endo-1,4-beta-xylanase | 著者 | Padua, R.A.P, Otten, R, Bunzel, A, Nguyen, V, Pitsawong, W, Patterson, M, Sui, S, Perry, S.L, Cohen, A.E, Hilvert, D, Kern, D. | 登録日 | 2020-09-16 | 公開日 | 2020-12-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.08 Å) | 主引用文献 | How directed evolution reshapes the energy landscape in an enzyme to boost catalysis. Science, 370, 2020
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8EQ5
| Crystal structure of the N-terminal kinase domain of RSK2 in complex with SPRED2 (131-160) | 分子名称: | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside, Ribosomal protein S6 kinase alpha-3, Sprouty-related, ... | 著者 | Bonsor, D.A, Lopez, J, McCormick, F, Simanshu, D.K. | 登録日 | 2022-10-07 | 公開日 | 2023-04-26 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | The ribosomal S6 kinase 2 (RSK2)-SPRED2 complex regulates the phosphorylation of RSK substrates and MAPK signaling. J.Biol.Chem., 299, 2023
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6G3E
| Crystal structure of EDDS lyase in complex with formate | 分子名称: | Argininosuccinate lyase, FORMIC ACID, SODIUM ION | 著者 | Poddar, H, Thunnissem, A.M.W.H, Poelarends, G.J. | 登録日 | 2018-03-25 | 公開日 | 2018-05-16 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural Basis for the Catalytic Mechanism of Ethylenediamine- N, N'-disuccinic Acid Lyase, a Carbon-Nitrogen Bond-Forming Enzyme with a Broad Substrate Scope. Biochemistry, 57, 2018
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5HYL
| Crystal structure of DR2231_E47A mutant in complex with dUMPNPP and magnesium | 分子名称: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, DR2231, MAGNESIUM ION | 著者 | Mota, C.S, Goncalves, A.M.D, de Sanctis, D. | 登録日 | 2016-02-01 | 公開日 | 2016-10-26 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Deinococcus radiodurans DR2231 is a two-metal-ion mechanism hydrolase with exclusive activity on dUTP. FEBS J., 283, 2016
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7K4S
| Crystal structure of Kemp Eliminase HG3.7 | 分子名称: | Endo-1,4-beta-xylanase, SULFATE ION | 著者 | Padua, R.A.P, Otten, R, Bunzel, A, Nguyen, V, Pitsawong, W, Patterson, M, Sui, S, Perry, S.L, Cohen, A.E, Hilvert, D, Kern, D. | 登録日 | 2020-09-16 | 公開日 | 2020-12-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | How directed evolution reshapes the energy landscape in an enzyme to boost catalysis. Science, 370, 2020
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7K16
| Tamana Bat Virus xrRNA1 | 分子名称: | MAGNESIUM ION, RNA (51-MER), SODIUM ION | 著者 | Jones, R.A, Kieft, J.S. | 登録日 | 2020-09-07 | 公開日 | 2020-10-14 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Different tertiary interactions create the same important 3D features in a distinct flavivirus xrRNA. Rna, 27, 2021
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5YA8
| Crystal structure of scyllo-inositol dehydrogenase with L-glucose dehydrogenase activity complexed with myo-inositol | 分子名称: | 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Scyllo-inositol dehydrogenase with L-glucose dehydrogenase activity | 著者 | Fukano, K, Shimizu, T, Sasaki, Y, Nakamura, A, Yajima, S. | 登録日 | 2017-08-31 | 公開日 | 2018-05-23 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural basis of L-glucose oxidation by scyllo-inositol dehydrogenase: Implications for a novel enzyme subfamily classification PLoS ONE, 13, 2018
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5KEG
| Crystal structure of APOBEC3A in complex with a single-stranded DNA | 分子名称: | CALCIUM ION, CHLORIDE ION, DNA (5'-D(*TP*TP*CP*TP*T)-3'), ... | 著者 | Kouno, T, Hilbert, B.J, Silvas, T, Royer, W.E, Matsuo, H, Schiffer, C.A. | 登録日 | 2016-06-09 | 公開日 | 2017-05-10 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity. Nat Commun, 8, 2017
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6HID
| The ATAD2 bromodomain in complex with compound 16 | 分子名称: | ATPase family AAA domain-containing protein 2, SULFATE ION, ~{N}-[4-ethanoyl-5-(4-morpholin-4-ylcarbonylphenyl)-1,3-thiazol-2-yl]piperazine-2-carboxamide | 著者 | Sledz, P, Caflisch, A. | 登録日 | 2018-08-29 | 公開日 | 2019-02-20 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.768 Å) | 主引用文献 | Hitting a Moving Target: Simulation and Crystallography Study of ATAD2 Bromodomain Blockers. Acs Med.Chem.Lett., 11, 2020
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